Groups

JCSMR is a centre of vibrant and innovative medical research.

The Andrews group - Genome Informatics »

A data revolution is underway in modern biological science, now that obtaining the genome sequence for an individual organism has become routine and increasingly affordable due to exponential advances in sequencing technologies. 

The Arabzadeh Group - Neural Coding »

The Neural Coding Group has a broad interest in systems neuroscience spanning areas such as sensory coding, adaptation and behaviour.

The Arkell Group - Early Mammalian Development »

We aim to understand the complex molecular processes by which these transcription factors interact with signal transduction pathways, chromatin, RNA and other proteins in order to orchestrate these important developmental processes

The Bekkers Group - Olfaction »

We are interested in how the mammalian brain processes sensory information received from the external world.

The Billups Group - Synaptic Mechanisms »

The Synaptic Mechanisms Laboratory investigates how individual synapses in the central nervous system function and how they are modulated.

The Board Group - Molecular Genetics »

The work of the Molecular Genetics Group is aimed at gaining a fundamental understanding of the molecular and biochemical mechanisms that underlie individual responses to such compounds.

The Bruestle Group - Inflammatory T Cell Responses »

The Bruestle Group - Inflammatory T Cell Responses, is focusing on different T helper cell subsets and how they modulate immunity in diverse autoimmune mouse models.

The Burgio Group - Genome Editing and Genetics of Host-Pathogens Interactions »

In the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infections. Our group aims to understand why these people are resistant to pathogens using a mouse as a model.

The Casarotto Group - Biomolecular Interactions »

The Biomolecular Structure Laboratory at the JCSMR seeks to carry out research that explores how the structural properties of biological molecules can impact on the biological process involved in health and disease.

The Cockburn Group - Malaria Immunology »

The focus of our research is understanding how to generate effective immunity against the malaria parasite Plasmodium.

The Cook Group - Translational Research »

The translational research group in immunology is seeking to understand the genetic etiology and cellular pathogenesis of human diseases arising from dysregulated immunity.

The Daria Group - Neurophotonics »

Our work is a multi-disciplinary collaborative venture between physicists and neuroscientists to make use of novel optical techniques to analyse the brain. We are mainly interested in using a 3D holographic projection of multiple foci from a single laser source.

The Dehorter Group - Neuronal Development »

The Dehorter Group aims to determine how interneurons shape neuronal networks activity and contribute to circuits balance in health and disease.

The Dulhunty Group - Muscle Research »

The research of the Group is dedicated to understanding the cellular mechanisms that underlie changes in cytoplasmic calcium signalling in general, and more specifically those mechanisms which trigger contraction following an electrical signal on the surface membrane of skeletal and cardiac muscle fibres.

The Easteal Group - Genome Diversity & Health »

We study the evolutionary interplay between humans and their environments to understand how this dynamic process gave rise to our complex biology; how it made us such a diverse species; and how it impacts our health and wellbeing.

The Enders Group - Models of human primary immunodeficiencies »

The main focus of the lab is to investigate novel pathways regulating B cell development and function.

The Fischer Group - Epigenetics and Genomic Stability »

The major research focus in the Fischer lab is to understand the connection between chromatin structure, pervasive transcription and RNA surveillance, and their influence on genomic stability and disease development, especially in cancer and ageing-related diseases.

The Foote Group - Genetics and Infectious Diseases »

I am interested in the genetics of several diseases that affect isolated, less affluent populations. My group works on the host response to infection by malarial parasites.

The Gardiner Group - Mechanisms of Thrombosis and Cancer »

The group investigates the molecular basis of processes coordinated by platelets across vascular biology. Primary areas of interest focus on the biochemical and molecular analysis of immune-based platelet disorders seen clinically in immunothrombocytopenia (ITP), thrombotic thrombocytopenic purpura (TTP) and heparin-induced thrombocytopenia (HIT) and the group has expanded their core interest to focus on thrombosis associated with cancer.

The Goodnow Group - Immunogenomics »

Our group discovers molecular and cellular mechanisms and genes regulating the immune response

The Gready Group - Computational & Conceptual Biology »

We aim to understand how proteins carry out their functions in the cell and how they have been sculpted by evolution to do so. Our findings provide the basic knowledge to understand proteins’ normal functions in plants and animals, and their dysfunctions in disease.

The Hannan Group - Cancer Therapeutics »

This group focuses on the molecular analysis of major pro-malignant transcription factor networks that operate in cancer cells using an integrated approach that combines cell biology, genomics, proteomics, biochemistry, genetics, bioinformatics and strong interactions with oncologists in the clinic.

The Hayashi Group - Transposon defence and animal development »

We are interested in learning gene expression control mechanisms through the lens of host-transposon interaction and how they, in turn, play roles in animal development.

The Lamb Group - Visual Neuroscience »

Our primary research interest is to elucidate the molecular mechanisms underlying phototransduction and adaptation - the conversion of light into a neural signal, and subsequent recovery, in retinal rod and cone photoreceptors and in bipolar cells.

The Li Group - Trauma and Orthopaedic Research  »

Dr Li is a molecular pharmacologist and osteoimmunologist with interests in understanding the processes that control a ‘foreign body reaction or response’ initiated by biomaterials implanted into bone or exposed to human bone cells.

The Lipotek Group »

Lipotek is a developer of targeted vaccine delivery and adjuvant technologies.

The Maddess Group - Diagnostics for Eye Diseases »

My interest in the optical designs of invertebrate eyes led me to study how visual systems squeeze real-time information into brains of limited capacity

The Man Group - Innate Immunity and Inflammasomes »

The Man Group investigates the role of innate immunity in infectious diseases and cancer.

The McMorran Group - Genetics and Infectious Diseases »

The main focus of our research is to understand the host response to malarial infection.

The Natoli Group - Clear Vision Research Lab »

Our lab studies a number of retinal diseases, with our main focus on finding novel diagnostics and treatment options for Age-Related Macular Degeneration (AMD).

The Parish Group - Cancer & Vascular Biology »

The Cancer and Vascular Biology Group has been working for a number of years on the molecular basis of cell adhesion, cell migration and cell invasion, with a particular emphasis on the immune system, tumour metastasis and the growth of new blood vessels (angiogenesis).

The Preiss Group - RNA Biology »

Our group studies the mechanisms and transcriptome-wide patterns of eukaryotic mRNA translation as one of life’s core processes and its regulation by RNA-binding proteins and non-coding RNA as a means of controlling gene activity.

The Provis Group - Gene expression in the human macula »

We aim to examine how the expression of macula genes varies over a lifetime.

The Quinn Group - Cancer Models »

The Quinn Group's current research involves generating genetic models using the vinegar fly (Drosophila Melanogaster) to understand the initiation and progression of human cancer.

The Ranasinghe Group - Molecular Mucosal Vaccine Immunology »

Our laboratory is attempting to understand the problems associated with HIV vaccine failure in humans. Our studies were the first to demonstrate that IL-4 and predominantly IL-13 play an important role in modulating “quality or avidity” of HIV-specific CD8 T cells in a vaccine route dependent manner where mucosal vaccination induced higher avidity CD8 T cells compared to systemic vaccination.

The Simeonovic Group - Diabetes/Transplantation Immunology »

We propose that during T1D development, neutrophils are activated by platelets to release NETs/histones inside blood vessels and within islets, resulting in initial or early beta cell damage.

The Song Group »

We study brain abnormalities in rats with Hirschsprung's disease.

The Stricker Group - Neuronal Networks »

We work in three different areas, each addressing a particular cellular property of transmission between cells. We record from cell pairs in various layers of cerebral cortex and investigate the characteristics of communication between cells. The goal is to determine the efficacy of the contacts between the cells, the mechanisms underlying its modulation, as well as the efficiency of information transfer between cells.

The Stuart Group - Neuronal Signalling »

The Neuronal Signalling Group studies the electrical and chemical signals that nerve cells in the brain use to communicate with one another.

The Tremethick Group - Chromatin and transcriptional regulation during development »

Chromatin and transcriptional regulation during development

The Tscharke Group - Viruses and Immunity »

Our research interests are Immunity to virus infection and in particular CD8+ T cells, poxviruses and herpesviruses and antigen presentation.

The Valter Group - Retinal Cell Damage and Repair »

My research has been focused on degenerative diseases of the retina, from the molecular and cellular level to the clinical.

The Vinuesa Group - Humoral Immunity & Autoimmunity »

The Humoral Immunity and Autoimmunity Group is investigating the cellular and molecular events that regulate production and selection versus elimination of memory B cells, which is of critical importance to understand how best to harness immune responses against infection, and to mitigate against autoimmunity.

The Wen Group - Computational Biology »

The Wen Group is a newly formed computational Biology group.

The Young Group - Cytokine Molecular Biology & Signalling »

One major aim is to study how the cytokines activate their receptor systems by binding to the receptors on the outside of cells and transmit intracellular signals which promote growth, differentiation, survival and activation of leukocytes. We use the techniques of protein expression, crystallization and X-ray crystallography to determine the structure of the receptors and site-directed mutagenesis to elucidate function. We are also interested in revealing the molecular mechanisms which promote self-renewal and differentiation of blood cell progenitors.

The Yu Group - T-cell Immune Mechanism, Monitoring and Modulation (TIM3) »

Dr Di Yu and his team are investigating the molecular mechanisms by which T cells control the competence and balance of the immune system, with the aim to design new strategies to modulate the immune system to treat autoimmune disease, infection and cancer.