The George Group - Pharmacogenomic Technologies
Associate Professor Amee George leads a specific research program into disorders of ribosome biogenesis (ribosomopathies) and the molecular mechanism(s) and signalling pathways which link this process to the nucleolus, a key structure in ribosome biogenesis. She is also a national specialist in high-throughput and high-content screening, leading the ANU Centre for Therapeutic Discovery.
Closely collaborating with the Hannan Group, the George Group has a research interest in:
- identifying disease biomarkers (genotype-phenotype) and therapeutic targets for drug discovery,
- utilising functional (RNAi/CRISPR) and molecule/biologic approaches and high-content imaging readouts
- developing new approaches to model disease in vitro, with a view to use these models for drug discovery projects (including complex 2D and 3D cellular models).
Leader
Researchers
Research support officers
Steins, A., Carroll, C., Choong, F.J., George, A.J., He, J.S., Parsons, K.M., Feng, S., Man, S.M., Kam, C., van Loon, L.M., Poh, P., Ferreira, R., Mann, G.J., Gruen, R.L., Hannan, K.M., Hannan, R.D. and Schulte, K.M. (2023). "Cell death and barrier disruption by clinically used iodine concentrations." Life Sci Alliance 6(6).
Hannan, K.M., Soo, P., Wong, M.S., Lee, J.K., Hein, N., Poh, P., Wysoke, K.D., Williams, T.D., Montellese, C., Smith, L.K., Al-Obaidi, S.J., Nunez-Villacis, L., Pavy, M., He, J.S., Parsons, K.M., Loring, K.E., Morrison, T., Diesch, J., Burgio, G., Ferreira, R., Feng, Z.P., Gould, C.M., Madhamshettiwar, P.B., Flygare, J., Gonda, T.J., Simpson, K.J., Kutay, U., Pearson, R.B., Engel, C., Watkins, N.J., Hannan, R.D. and George, A.J. (2022). "Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway." Cell Rep 41(5): 111571.
Gauthier-Coles, G., Broer, A., McLeod, M.D., George, A.J., Hannan, R.D. and Broer, S. (2022). "Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells." Front Pharmacol 13: 963066.
Hicks, S.M., Pohl, K., Neeman, T., McNamara, H.A., Parsons, K.M., He, J.S., Ali, S.A., Nazir, S., Rowntree, L.C., Nguyen, T.H.O., Kedzierska, K., Doolan, D.L., Vinuesa, C.G., Cook, M.C., Coatsworth, N., Myles, P.S., Kurth, F., Sander, L.E., Mann, G.J., Gruen, R.L., George, A.J., Gardiner, E.E., Cockburn, I.A. and Collaborators, S.A.-C.-T.i.E.S. (2021). "A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting." J Infect Dis 223(1): 10-14.
Chin, C.V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K.M., He, J., George, A.J., Pallotta, M.M., Musio, A., Braithwaite, A., Guilford, P., Hannan, R.D. and Horsfield, J.A. (2020). "Cohesin mutations are synthetic lethal with stimulation of WNT signaling." Elife 9.
Chan, K.T., Blake, S., Zhu, H., Kang, J., Trigos, A.S., Madhamshettiwar, P.B., Diesch, J., Paavolainen, L., Horvath, P., Hannan, R.D., George, A.J., Sanij, E., Hannan, K.M., Simpson, K.J. and Pearson, R.B. (2020). "A functional genetic screen defines the AKT-induced senescence signaling network." Cell Death Differ 27(2): 725-741.
Nunez Villacis, L., Wong, M.S., Ferguson, L.L., Hein, N., George, A.J. and Hannan, K.M. (2018). "New Roles for the Nucleolus in Health and Disease." Bioessays 40(5): e1700233.
He, J.S., Soo, P., Evers, M., Parsons, K.M., Hein, N., Hannan, K.M., Hannan, R.D. and George, A.J. (2018). "High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology." Assay Drug Dev Technol 16(6): 320-332.
Venugopal, P., Moore, S., Lawrence, D.M., George, A.J., Hannan, R.D., Bray, S.C., To, L.B., D'Andrea, R.J., Feng, J., Tirimacco, A., Yeoman, A.L., Young, C.C., Fine, M., Schreiber, A.W., Hahn, C.N., Barnett, C., Saxon, B. and Scott, H.S. (2017). "Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient." Haematologica 102(12): e506-e509.
Hein, N., Cameron, D.P., Hannan, K.M., Nguyen, N.N., Fong, C.Y., Sornkom, J., Wall, M., Pavy, M., Cullinane, C., Diesch, J., Devlin, J.R., George, A.J., Sanij, E., Quin, J., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D., Harrison, S.J., Rozario, J.D., Powell, J.A., Pitson, S.M., Zuber, J., Johnstone, R.W., Dawson, M.A., Guthridge, M.A., Wei, A., McArthur, G.A., Pearson, R.B. and Hannan, R.D. (2017). "Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population." Blood 129(21): 2882-2895.
George, A.J., Allen, A. and Chand, A.L. (2017). "Repurposing ARBs as treatments for breast cancer." Aging (Albany NY) 9(5): 1357-1358.
Coulson, R., Liew, S.H., Connelly, A.A., Yee, N.S., Deb, S., Kumar, B., Vargas, A.C., O'Toole, S.A., Parslow, A.C., Poh, A., Putoczki, T., Morrow, R.J., Alorro, M., Lazarus, K.A., Yeap, E.F.W., Walton, K.L., Harrison, C.A., Hannan, N.J., George, A.J., Clyne, C.D., Ernst, M., Allen, A.M. and Chand, A.L. (2017). "The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma." Oncotarget 8(12): 18640-18656.
Quin, J., Chan, K.T., Devlin, J.R., Cameron, D.P., Diesch, J., Cullinane, C., Ahern, J., Khot, A., Hein, N., George, A.J., Hannan, K.M., Poortinga, G., Sheppard, K.E., Khanna, K.K., Johnstone, R.W., Drygin, D., McArthur, G.A., Pearson, R.B., Sanij, E. and Hannan, R.D. (2016). "Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling." Oncotarget 7(31): 49800-49818.
Devlin, J.R., Hannan, K.M., Hein, N., Cullinane, C., Kusnadi, E., Ng, P.Y., George, A.J., Shortt, J., Bywater, M.J., Poortinga, G., Sanij, E., Kang, J., Drygin, D., O'Brien, S., Johnstone, R.W., McArthur, G.A., Hannan, R.D. and Pearson, R.B. (2016). "Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma." Cancer Discov 6(1): 59-70.
Chan, K.T., Paavolainen, L., Hannan, K.M., George, A.J., Hannan, R.D., Simpson, K.J., Horvath, P. and Pearson, R.B. (2016). "Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence." Assay Drug Dev Technol 14(7): 416-428.
Sjogren, S.E., Siva, K., Soneji, S., George, A.J., Winkler, M., Jaako, P., Wlodarski, M., Karlsson, S., Hannan, R.D. and Flygare, J. (2015). "Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia." Br J Haematol 171(4): 517-529.
Hein, N., Hannan, K.M., George, A.J., Sanij, E. and Hannan, R.D. (2013). "The nucleolus: an emerging target for cancer therapy." Trends Mol Med 19(11): 643-654.
George, A.J., Purdue, B.W., Gould, C.M., Thomas, D.W., Handoko, Y., Qian, H., Quaife-Ryan, G.A., Morgan, K.A., Simpson, K.J., Thomas, W.G. and Hannan, R.D. (2013). "A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation." J Cell Sci 126(Pt 23): 5377-5390.
George, A.J., Hannan, R.D. and Thomas, W.G. (2013). "Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches." FEBS J 280(21): 5258-5268.
Wong, L.H., McGhie, J.D., Sim, M., Anderson, M.A., Ahn, S., Hannan, R.D., George, A.J., Morgan, K.A., Mann, J.R. and Choo, K.H. (2010). "ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells." Genome Res 20(3): 351-360.
George, A.J., Thomas, W.G. and Hannan, R.D. (2010). "The renin-angiotensin system and cancer: old dog, new tricks." Nat Rev Cancer 10(11): 745-759.
George, A.J., Gordon, L., Beissbarth, T., Koukoulas, I., Holsinger, R.M., Perreau, V., Cappai, R., Tan, S.S., Masters, C.L., Scott, H.S. and Li, Q.X. (2010). "A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model." Neurotox Res 17(4): 360-379.
Petratos, S., Li, Q.X., George, A.J., Hou, X., Kerr, M.L., Unabia, S.E., Hatzinisiriou, I., Maksel, D., Aguilar, M.I. and Small, D.H. (2008). "The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism." Brain 131(Pt 1): 90-108.
George, A.J., Holsinger, R.M., McLean, C.A., Tan, S.S., Scott, H.S., Cardamone, T., Cappai, R., Masters, C.L. and Li, Q.X. (2006). "Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease." Neurobiol Aging 27(4): 614-623.
George, A.J., Holsinger, R.M., McLean, C.A., Laughton, K.M., Beyreuther, K., Evin, G., Masters, C.L. and Li, Q.X. (2004). "APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease." Neurobiol Dis 16(1): 124-132.
