The Stuart Group - Neuronal Signalling
The Neuronal Signalling Group studies the electrical and chemical signals that nerve cells in the brain use to communicate with one another. The Group uses state-of-the-art optical and electrical recording techniques to address fundamental questions in neuroscience, such as how the brain processes information about the outside world and how we learn and remember. Our research addresses issues relevant to neurological diseases such as epilepsy, schizophrenia and dementia.
Leader
Researchers
Students
Administrator
Broersen, R & Stuart, GJ. (2023) In vivo whole-cell recording from morphologically identified mouse superior colliculus neurons. Star Protocols 4(1), 101963.
Testa-Silva, G., Rosier, M., Honnuraiah, S., Guzulaitis, R., Morello Megias, A., French, C., King, J., Drummond, K., Palmer, L.M. & Stuart, G.J. (2022) Higher synaptic threshold for NMDA spike generation in human neurons. Cell Reports 41 (11), 111787.
To, M-S., Honnuraiah, S. & Stuart, G.J. (2022) Voltage clamp errors during estimation of concurrent excitatory and inhibitory synaptic input to neurons with dendrites. Neuroscience, 489:98-110. doi: 10.1016/j.neuroscience.2021.08.024.
Alwis, D., Godenzini, L, Guzulaitis, R., Honnuraiah, S., Stuart, G.J. & Palmer, L.M. (2021) Auditory input enhances somatosensory encoding and tactile goal-directed behavior. Nature Communications, 12:4509. doi: 10.1038/s41467-021-24754-w.
Sah, P., Stuart, G.J. and Egan, G. (2020) Integrative Brain Function Down Under. Frontiers in Neural Circuits 14:48. doi: 10.3389/fncir.2020.00048.
Hanlon, L., Gautam, V., Wood, J.D.A., Reddy, P., Barson, M.S.J., Niihori, M., Silalahi, A.R.J., Corry, B., Wrachtrup, J., Sellars, M.J., Daria, V.R., Maletinsky, P., Stuart, G.J., and Doherty, M.W. (2020) Diamond nano-pillar arrays for quantum microscopy of neuronal signals. Neurophotonics 7(3), 035002. https://doi.org/10.1117/1.NPh.7.3.035002.
GharaeiS., Honnuraiah, S., Arabzadeh, E.and Stuart, G.J (2020) Superior colliculus modulates cortical coding of somatosensory information, Nature Communications 11, 1693. doi: 10.1038/s41467-020-15443-1.
Bock, T., Honnuraiah, S. and Stuart, G.J. (2019) Paradoxical excitatory impact of SK channels on dendritic excitability. Journal of Neuroscience 39, 7826-7839.
Connelly, W.M. and Stuart, G.J. (2019) Local versus global dendritic integration. Neuron 103, 173-174.
Loutit, A.J., Shivdasani, M.N, Maddess, T., Redmond, R.J., Morley, J.W., Stuart, G.J., Birznieks, I., Vickery, R.M. and Potas, J.R. (2019) Peripheral Nerve Activation Evokes Machine-Learnable Signals in the Dorsal Column Nuclei. Frontiers in System Neuroscience 13(11) doi: 10.3389/fnsys.2019.00011.
Australian Brain Alliance (2019) A neuroethics framework for the Australian brain initiative. Neuron 101, 365-369.
Lissek, T. et al (2017) Building bridges through science. Neuron 96, 730-735.
Breton, J.D and Stuart, G.J. (2017) Differential coupling of GABAB receptors to GIRK and TASK potassium channels in hippocampal and cortical pyramidal neurons. European Journal of Neuroscience 46, 2859-2866.
Jones, S.L, To, M-S and Stuart, G.J. (2017) Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent plasticity. eLife 6:e30333, doi: 10.7554/eLife.30333.
Loutit, A.J., Maddess, T, Redmond, S.J., Morley, J.W., Stuart, G.J and Potas, J.R. (2017) Predicting the location of peripheral stimulation from dorsal column nuclei surface potentials. J. Physiology (London) 595, 4507–4524.
Australian Brain Alliance (2016) Australian Brain Alliance Steering Committee. Neuron 92, 597-600.
Bock, H.T. and Stuart, G.J. (2016) Impact of BK channels on cellular excitability depends on their subcellular location. Frontiers in Cellular Neuroscience 10:206, 1-8. doi: 10.3389/fncel.2016.00206
Bock, T. and Stuart, G.J. (2016) Impact of calcium-activated potassium channels on NMDA spikes in cortical layer 5 pyramidal neurons. J. Neurophysiology 115, 1740–1748.
Stuart, G.J and Spruston, N. (2015) Dendritic integration: 60 years of progress. Nature Neuroscience 18, 1713-1721.
Go, M.A, To, M-S, Stricker, C, Redman, S, Bachor, H-A, Stuart, G.J. and Daria, V.R. (2013) Four-dimensional multi-site photolysis of caged neurotransmitters. Frontiers in Cellular Neuroscience 7:231, 1-9 (10.3389/fncel.2013.00231).
Jones, S.L. and Stuart, G.J. (2013) Different calcium sources control somatic versus dendritic SK channel activation during action potentials, J. Neuroscience 33, 19396-19405.
Longordo, F, To, M-S, Ikeda, K and Stuart, G.J. (2013) Sublinear integration underlies binocular processing in primary visual cortex, Nature Neuroscience 16, 714-23.
Breton, J.D and Stuart, G.J. (2012) GABAB receptors regulate somatic and dendritic excitability via different mechanism. J. Neurophysiology 108, 2810-18.
Stuart, G.J. (2012) Dendritic spikes veto inhibition. Neuron 75, 744-6.
Hallermann, S, de Kock, C.P.J, Stuart, G.J. and Kole, M.H. (2012) State- and location-dependence of action potential cost in cortical pyramidal neurons, Nature Neuroscience 15, 1007-1014.
Gulledge, A.T, Carnevale, N.T. and Stuart G.J. (2012) Electrical advantages of dendritic spines, PLoS ONE 7(4): e36007. doi:10.1371/journal.pone.0036007.
Kole, M.H. and Stuart, G.J. (2012) Signal processing in the axon initial segment. Neuron 73, 235-247.
Froemke, R.C, Letzkus, J.J, Kampa, B.M, Hang, G.B, and Stuart, G.J (2010) Dendritic synapse location and neocortical spike-timing-dependent plasticity. Frontiers in Cellular Neuroscience 2(29), 1-14.
Palmer, L.M, Clark B.A, Gründemann J, Roth, A, Stuart, G.J. and Häusser, M. (2010) Initiation of simple and complex spikes in cerebellar Purkinje cells. J. Physiology (London), 588, 1709-17.
Breton, J.D. and Stuart, G.J. (2009) Loss of sensory input increases the intrinsic excitability of layer 5 pyramidal neurons in rat barrel cortex. J. Physiology (London) 587, 5107-19.
Palmer L.M. and Stuart G.J. (2009) Membrane potential changes in dendritic spines during action potentials and synaptic input. J Neuroscience 29, 6897-903.
Kole, M.H. and Stuart, G.J. (2008) Is action potential threshold lowest in the axon? Nature Neuroscience 11, 1253-55.
Letzkus, J.J. and Stuart, G.J. (2008) All asleep-but inhibition is wide awake. Neuron 57, 804-6.
Kole, M.H., Ischner, S.U., Kampa, B.M., Williams, S.R., Ruben, P.C. and Stuart, G.J. (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nature Neuroscience 11, 178-86.
Kole, M.H., Letzkus, J.J. and Stuart, G.J. (2007) Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron 55, 633-47.
Letzkus, J.J., Kampa, B.M. and Stuart, G.J. (2007) Does spike-timing-dependent synaptic plasticity underlie memory formation? Clinical Experimental Pharmacology and Physiology 34, 1070-6.
Kampa, B.M., Letzkus, J.J. and Stuart, G.J. (2007) Dendritic mechanisms controlling spike-timing dependent synaptic plasticity. Trends in Neurosciences 30, 456-63.
Kole, M.H., Brauer, A.U. and Stuart, G.J. (2007). Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model. J. Physiology (London) 578, 507-525.
Gulledge, A.T., Park, S.B., Kawaguchi, Y. and Stuart, G.J. (2007). Heterogeneity of phasic cholinergic signalling in neocortical neurons. J. Neurophysiology 97, 2215-2229.
Stuart, G.J. and Palmer, L.M. (2006). Imaging membrane potential in dendrites and axons of single neurons. Pflugers Archive 453, 403-410.
Kampa, B.M., Letzkus, J.J. and Stuart, G.J. (2006). Cortical feed-forward networks for binding different streams of sensory information. Nature Neuroscience 9, 1472-1473.
Davie, J.T., Kole, M.H., Letzkus, J.J., Rancz, E.A., Spruston, N., Stuart, G.J. and Hausser, M. (2006). Dendritic patch-clamp recording. Nature Protocols 1, 1235-1247.
Letzkus, J.J., Kampa, B.M. and Stuart, G.J. (2006). Learning rules for spike timing-dependent plasticity depend on dendritic synapse location. J. Neuroscience 26, 10420-10429.
Kampa, B.M. and Stuart, G.J. (2006). Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. J. Neuroscience 26, 7424-7432.
Kampa, B.M., Letzkus, J.J. and Stuart, G.J. (2006). Requirement of dendritic calcium spikes for induction of spike-timing-dependent synaptic plasticity. J. Physiology (London) 574, 283-290.
Kole, M.H., Hallermann, S. and Stuart, G.J. (2006). Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. J. Neuroscience 26, 1677-1687.
Palmer, L.M. and Stuart, G.J. (2006). Site of action potential initiation in layer 5 pyramidal neurons. J. Neuroscience 26, 1854-1863.
Gulledge, A.T. and Stuart, G.J. (2005). Cholinergic inhibition of neocortical pyramidal neurons. J. Neuroscience 25, 10308-10320.
Gulledge, A.T., Kampa, B.M. and Stuart, G.J. (2005). Synaptic integration in dendritic trees. J. Neurobiology 64, 75-90.
Kampa, B.M., Clements, J., Jonas, P. and Stuart, G.J. (2004). Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. J. Physiology (London) 556, 337-345.
Williams, S.R. and Stuart, G.J. (2003). Role of dendritic synapse location in the control of action potential output. Trends Neuroscience 26, 147-154.
Williams, S.R. and Stuart, G.J. (2003). Voltage- and site-dependent control of the somatic impact of dendritic IPSPs. J. Neuroscience 23, 7358-7367.
Gulledge, A.T., and Stuart, G.J. (2003). Excitatory actions of GABA in the cortex. Neuron 37, 299-309.
Gulledge, A.T., and Stuart, G.J. (2003). Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation. J. Neuroscience 23, 11363-11372.
Williams, S.R., and Stuart, G.J. (2002). Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons. Science 295, 1907-1910.
Williams, S.R., Christensen, S.R., Stuart, G.J. and Hausser, M. (2002). Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro. J. Physiology (London) 539, 469-483.
Stuart, G.J. (2001). Determinants of spike timing-dependent synaptic plasticity. Neuron 32, 966-968.
Stuart, G.J. and Hausser, M. (2001). Dendritic coincidence detection of EPSPs and action potentials. Nature Neuroscience 4, 63-71.
Hausser, M., Major, G. and Stuart, G.J. (2001). Differential shunting of EPSPs by action potentials. Science 291, 138-141.
Williams, S.R. and Stuart, G.J. (2000). Action potential backpropagation and somato-dendritic distribution of ion channels in thalamocortical neurons. J. Neuroscience 20, 1307-1317.
Hausser, M., Spruston, N. and Stuart, G.J. (2000). Diversity and dynamics of dendritic signaling. Science 290, 739-744.
Williams, S.R. and Stuart, G.J. (2000). Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons. J. Neurophysiology 83, 3177-3182.
Williams, S.R. and Stuart, G.J. (2000). Backpropagation of physiological spike trains in neocortical pyramidal neurons: implications for temporal coding in dendrites. J. Neuroscience 20, 8238-8246.
Gentet, L.J., Stuart, G.J. and Clements, J.D. (2000). Direct measurement of specific membrane capacitance in neurons. Biophysics J. 79, 314-320.
Williams, S.R., and Stuart, G.J. (1999). Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons. J. Physiology (London) 467-482.
Stuart, G. (1999). Voltage-activated sodium channels amplify inhibition in neocortical pyramidal neurons. Nature Neuroscience 2, 144-150.
Stuart, G. and Spruston, N. (1998). Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J. Neuroscience 18, 3501-3510.
Stuart, G. Spruston, N., Sakmann, B., and Hausser, M. (1997). Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends in Neurosciences 20, 125-131.
Stuart, G. Schiller, J., and Sakmann, B. (1997). Action potential initiation and propagation in rat neocortical pyramidal neurons. J. Physiology (London) 505, 617-632.
Schiller, J., Schiller, Y., Stuart, G. and Sakmann, B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. J. Physiology (London) 505, 605-616.
Stuart, G. and Sakmann, B. (1995). Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 15, 1065-1076.
Stuart, G. and Spruston, N. (1995). Probing dendritic function with patch pipettes. Current Opinion Neurobiology 5, 389-394.
Spruston, N., Schiller, Y., Stuart, G. and Sakmann, B. (1995). Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 268, 297-300.
Hausser, M., Stuart, G., Racca, C. and Sakmann, B. (1995). Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron 15, 637-647.
Stuart, G. and Hausser, M. (1994). Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13, 703-712.
Stuart, G.J. and Sakmann, B. (1994). Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367, 69-72.
Stuart, G.J. Dodt, H.U., and Sakmann, B. (1993). Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Archive 423, 511-518.
Stuart, G.J. and Redman, S.J. (1992). The role of GABAA and GABAB receptors in presynaptic inhibition of Ia EPSPs in cat spinal motoneurones. J. Physiology (London) 447, 675-692.
Stuart, G.J. and Redman, S.J. (1991). Mechanisms of presynaptic inhibition studied using paired-pulse facilitation. Neuroscience Letter 126, 179-183.
Stuart, G.J. and Redman, S.J. (1990). Voltage dependence of Ia reciprocal inhibitory currents in cat spinal motoneurones. J. Physiology (London) 420, 111-125.
Stuart, G.J., Rymer, W.Z. and Schotland, J.L. (1986). Characteristics of reflex excitation in close synergist muscles evoked by muscle vibration. Experimental Brain Research 65, 127-134.
Proske, U. and Stuart, G.J. (1985). The initial burst of impulses in responses of toad muscle spindles during stretch. J. Physiology (London) 368, 1-17.
Books
Dendrites, 3rd Edition (2016). Ed. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford.
Dendrites, 2nd Edition (2008). Ed. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford.
Dendrites (1999). Ed. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford.
Book Chapters
Gharaei, S., Stuart, G.J. and Arabzadeh, E (2020) Collicular Anatomy and Function. In: The Senses: A Comprehensive Reference, 2nd edition, Volume 1 https://doi.org/10.1016/B978-0-12-809324-5.24253-3.
Castanares, M., Stuart, G.J., and Daria, V. (2018) Holographic Functional Calcium Imaging of Neuronal Circuit Activity. In: Kao FJ., Keiser G., Gogoi A. (eds) Advanced Optical Methods for Brain Imaging. Progress in Optical Science and Photonics, vol 5. Springer, Singapore.
Häusser, M., Spruston, N. and Stuart, G. (2016). The future of dendrite research. In: Dendrites, 3rd Edition. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford, p. 703-707.
Spruston, N., Stuart, G. and Häusser, M. (2016). Principles of dendritic integration. In: Dendrites, 3rd Edition. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford, p. 351-398 .
Spruston, N., Häusser, M, and Stuart, G. (2013) Information processing in dendrites and spines. In: Fundamental Neuroscience, 4th Edition. L. Squire et al. Elsevier Inc.
Etherington, S.J., Atkinson, S.E., Stuart, G.J. and Williams, S.R. (2010). Synaptic integration. In: Encyclopedia of Life Sciences (ID: A21422), MacMillan/ www.els.net.
Häusser, M., Spruston, N. and Stuart, G. and (2008). Conclusion: The future of dendrite research. In: Dendrites, 2nd Edition. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford, p. 551-554.
Spruston, N., Stuart, G. and Häusser, M. (2008). Dendritic integration. In: Dendrites, 2nd Edition. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford, p. 351-399.
Stuart, G.J. and Williams, S.R. (2001). Synaptic integration. In: Encyclopedia of Life Sciences, MacMillan/ www.els.net.
Spruston, N., Stuart, G. and Häusser, M. (1999). Conclusion: The future of dendrite research. In: Dendrites. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford, p. 231-270.
Spruston, N., Stuart, G. and Häusser, M. (1999). Dendritic integration. In: Dendrites. G. Stuart, N. Spruston & M. Häusser, Oxford University Press, Oxford, p. 231-270.
Stuart, G. (1998). Patch-pipette recording in brain slices. In: Current protocols in Neuroscience. Ed. V. Chanda, John Wiley & Sons, NY, p. 6.7.1 - 6.7.10.
Sakmann, B. and Stuart, G. (1995). Patch-clamp recording from the soma, dendrites and axon of neurones in brain slices. In: Single-Channel Recording. Ed. B. Sakmann & E. Neher. Plenum Press, NY, p. 199-211.
