Our group studies the mechanisms and transcriptome-wide patterns of eukaryotic mRNA translation as one of life’s core processes and its regulation by RNA-binding proteins and non-coding RNA as a means of controlling gene activity. Translation takes place on the ribosome and is aided by numerous accessory factors. Control at this post-transcriptional level makes major contributions to gene regulation and its dysregulation is increasingly recognised as an important factor in human disease. Pathologic mechanisms may perturb the activity of components of the translational machinery with a broad impact on the cellular translation program, leading to, for instance, malignant transformation, inappropriate cell death or cardiac hypertrophy. Failure to properly regulate the translation of specific mRNAs is also linked to a growing spectrum of diseases. We investigate post-transcriptional gene control in mammalian and yeast cell models and employ a mix of conventional molecular biology approaches as well as global methods such as next-generation sequencing.
Enquiries are welcome from potential Honours or PhD students with an interest in RNA biology. A variety of projects are available within all of the areas of research undertaken by this Group.
- How cells master the art of reading life's recipes 21 July 2016
- Protein insights to help find heart disease cure 26 July 2016
- New honour for ANU medical researcher 17 April 2016
- Unlocking the secrets of stem cell generation ANU media release and video clip
- One step back, 10 steps forward for stem cells The Australian 3 January 2015
- New stem cell opens door to regenerationThe Australian 11 December 2014
- Researchers identify stem cells that can be reprogrammed The Canberra Times 11 December 2014
- 'Grow your own' body parts a step closer after stem cell breakthrough The Age 11 December 2014
- International study a major step forward in stem cell treatment research ABC Online 11 December 2014
- Australian researchers discover new ways to grow body parts for transplant ABC News 11 December 2014
- ANU role in stem cell research Canberra Times 11 December 2014
- Dr Jen Clancy and Professor Thomas Preiss have their paper featured on the cover of Nature Chemical Biology 2 May 2014
- Professor Thomas Preiss awarded The Julian Wells Medal at Lorne 17 February 2014
- Further information on the recent reprogramming papers