The Preiss group studies the mechanisms and transcriptome-wide patterns of RNA-level gene regulation in eukaryotes, an area of strong general interest as much of our genome is transcribed into a myriad of RNAs, many with unknown functions. The general intent is to chart the complexity of such transcription outputs and how transcriptome function is shaped through RNA processing/modification and dynamic RNA-protein interactions. Dysregulation of RNA-level control abounds in disease; hence the group’s research addresses human health in diverse ways, with a particular emphasis on contributions to cancer and cardiac biology. The work is primarily based in mammalian and yeast cell culture models and employs a mix of classic molecular biology and contemporary ‘omics’ approaches.
One main focus is mRNA translation, a process that takes place on the ribosome and is divided into initiation, elongation and termination phases, each aided by numerous distinct accessory factors. The group uses specialised high-throughput sequencing methods to better understand the mechanism of translation and how it is regulated by cellular signalling, RNA-binding proteins and non-coding RNAs. For example, the group has made important contributions to the understanding of ribosome recruitment to mRNA during the initiation phase of translation. To achieve this, they innovated the sequencing and mapping of footprints of ribosomal complexes along mRNA; their approach, termed translation complex profile sequencing, is related to the popular ‘ribosome profiling’ method. They have also characterised how microRNAs repress translation initiation and how regulated transcription termination creates mRNA isoforms that are either subjected to, or evade, microRNA-mediated repression.
The group is further contributing to the bourgeoning epitranscriptomics field, concerned with the functional study of RNA modifications. Specifically, they pioneered the mapping of 5-methylcytosine in the human transcriptome and linked its presence in mRNA to translation. Their interest in the surprisingly prevalent group of circular RNAs, has led them to describe aspects of their unusual biogenesis through ‘back-splicing’ and their potential function in protein synthesis. Finally, using the tools of proteomics, the Preiss group is also on the hunt for proteins that, besides their recognised function, ‘moonlight’ in RNA-binding. This has revealed a surprisingly frequent crosstalk between RNA biology and other cellular processes such as intermediary metabolism.
The above-mentioned areas of RNA biology are all actively researched in the Preiss Group and enquiries for currently available projects are welcome from potential Honours or PhD students.
Media links
2016
- How cells master the art of reading life's recipes 21 July 2016
- Protein insights to help find heart disease cure 26 July 2016
- New honour for ANU medical researcher 17 April 2016
2015
- Unlocking the secrets of stem cell generation ANU media release and video clip
2014
- Researchers identify stem cells that can be reprogrammed The Canberra Times 11 December 2014
- International study a major step forward in stem cell treatment research ABC Online 11 December 2014
- Australian researchers discover new ways to grow body parts for transplant ABC News 11 December 2014
- ANU role in stem cell research Canberra Times 11 December 2014
- Dr Jen Clancy and Professor Thomas Preiss have their paper featured on the cover of Nature Chemical Biology 2 May 2014
- Professor Thomas Preiss awarded The Julian Wells Medal at Lorne 17 February 2014
- Further information on the recent reprogramming papers
ANU 3MT Winners from our group:
2019: Lithin Louis
2022: Yu-Ting (Jennifer) Hung
Life Science Across the Globe seminar moderated by Professor Thomas Preiss
Leader
Researchers
Research support officers
Students
- Wagner S, Herrmannová A, Hronová V et al 2020 Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes. Mol Cell, 79(4):546–560.e7
- Schumann U, Zhang HN, Sibbritt T et al 2020 Multiple links between 5-methylcytosine content of mRNA and translation. BMC Biol18:40
- Janin M, Ortiz-Barahona V, Castro de Moura M, et al 2019 Epigenetic Loss of Ribosomal RNA Methyltransferase NSUN5 in Glioma Drives a Stress Adaptive Translational Program. Acta Neuropathol, 2019; 135:601.
- Sen ND, Gupta N, Archer S, et al 2019 Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo. Nucleic Acids Res ; 83:779.
- Ragan C, Goodall GJ, Shirokikh NE*, Preiss T*. 2019 Insights into the biogenesis and potential functions of exonic circular RNA. Sci Rep ; 9(1): 2048.
- Shirokikh NE, Dutikova J, Staroverova M, Hannan R, Preiss T. 2019 Migration of small ribosomal subunits on the 5' untranslated regions of capped messenger RNA Int J Mol Sci 20(18):4464.
- Bommer UA, Preiss T. Neue RNA-Moleküle und die Regulation der Genexpression auf Translationsebene. [New RNA molecules and regulation of gene expression at the level of translation.] BIOspektrum 2019; 25(3):350-351
- Janapala Y, Preiss T, ShirokikhN. 2019 Control of translation at the initiation phase during glucose starvation in yeast. Int J Mol Sci; 20(16):E4043.
- Swaminathan A, Harrison PA, Preiss T, Beilharz TH. 2019 PAT-Seq: A method for simultaneous quantitation of gene expression, poly(A)-site selection and poly(A)-length distribution in yeast transcriptomes. In: Oliver SG, Castrillo JI, eds. Methods Mol Biol
- Faunce, T, Ray, A, Gardiner, C et al 2018, 'Regulating RNA Research and CRISPR Gene Drives to Combat Biosecurity Threats', Journal of Law and Medicine, vol. 26, no. 1, pp. 208-213.
- Hentze, MW, Castello, A, Schwarzl, T et al 2018, 'A brave new world of RNA-binding proteins', Nature Reviews: Molecular Cell Biology, vol. 19, no. 5, pp. 327-341.
- Rasko, J & Preiss, T 2018, 'Editorial: Diversity of transcripts emanating from protein-coding genes', Seminars in Cell and Developmental Biology, vol. 75, pp. 1-2.
- Shirokikh, N & Preiss, T 2018, 'Cover Image', Wiley Interdisciplinary Reviews: RNA , vol. 9, no. 4, pp. e1490.
- Shirokikh, N & Preiss, T 2018, 'Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions', Wiley Interdisciplinary Reviews: RNA , vol. 9, no. 4, pp. e1473 (1-45).
- David, R, Burgess, A, Parker, B et al 2017, 'Transcriptome-wide mapping of RNA 5-methylcytosine in arabidopsis mRNAs and noncoding RNAs', The Plant Cell, vol. 29, no. 3, pp. 445-460.
- Shirokikh NE, Archer SK, Beilharz TH, Powell D and Preiss T (2017) Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and termination. Nature Protocols 12:697–731
- Shafik, A, Schumann, U, Evers, M et al 2016, 'The emerging epitranscriptomics of long noncoding RNAs', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, no. 1, pp. 59-70.
- Preiss, T 2016, 'All Ribosomes Are Created Equal. Really?', Trends in Biochemical Sciences, vol. 41, no. 2, pp. 121-123.
- Soetanto, R, Hynes, C, Patel, H et al 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, no. 5, pp. 744-756.
- Schumann, U, Shafik, A & Preiss, T 2016, 'METTL3 Gains R/W Access to the Epitranscriptome', Molecular Cell, vol. 62, no. 3, pp. 323-324.
- Archer, S, Shirokikh, N, Beilharz, T et al 2016, 'Dynamics of ribosome scanning and recycling revealed by translation complex profiling', Nature, vol. 535, no. 7613, pp. 570-574.
- Liao, Y, Castello, A, Fischer, B et al 2016, 'The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease', Cell Reports, vol. 16, no. 5, pp. 1456-1469.
- Liepelt, A, Naarmann-de Vries, I, Simons, N et al 2016, 'Identification of RNA-binding proteins in macrophages by interactome capture', Molecular and Cellular Proteomics, vol. 15, no. 8, pp. 2699-2714.
- Reichel, M, Liao, Y, Rettel, M et al 2016, 'In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings.', The Plant Cell, vol. 28, pp. 2435-2452.
- Singhania, R, Pavey, S, Payne, E et al 2016, 'Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1859, no. 8, pp. 1034-1042.
- Wong, QWL, Lee, Q, Vaz, C et al 2016, 'Embryonic stem cells exhibit mRNA isoform specific translational regulation', PLOS ONE (Public Library of Science), vol. 11, no. 1, e0143235.
- Archer, S, Shirokikh, N & Preiss, T 2015, 'Probe-directed degradation (PDD) for flexible removal of unwanted cDNA sequences from RNA-seq libraries', in A. Boyle, J.L Haines, B. R Korf (ed.), Current Protocols in Human Genetics, John Wiley & Sons Inc., New Jersey, USA, pp. 11.15.1-11.15.36.
- Castello, A, Hentze, M & Preiss, T 2015, 'Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins', Trends in Endocrinology and Metabolism, vol. 26, no. 12, pp. 746-757.
- Fu, N, Rios, A, Pal, B et al 2015, 'EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival', Nature Cell Biology, vol. 17, no. 4, pp. 365-375.
- Archer, S, Shirokikh, N, Hallwirth, C et al 2015, 'Probing the closed-loop model of mRNA translation in living cells', RNA Biology, vol. 12, no. 3, pp. 248-254.
- Harrison, P, Powell, D, Clancy, J et al 2015, 'PAT-seq: A method to study the integration of 3'-UTR dynamics with gene expression in the eukaryotic transcriptome', RNA, vol. 21, no. 8, pp. 1502-1510.
- Sibbritt, T, Shafik, A, Clarke, S et al 2016, 'Nucleotide-Level Profiling of m5C RNA Methylation', in Methods Mol Biol, Erik Dassi (ed.), Post-Transcriptional Gene Regulation, Humana Press, New York, vol. 1358, pp. 269-284.
- Srivastava, M, Duan, G, Kershaw, NJ et al 2015, 'Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.', Nature Communications, vol. 6, no. 6253.
- Keam, S, Young, P, McCorkindale, A et al 2014, 'The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells', Nucleic Acids Research, vol. 42, no. 14, pp. 8984-8995.
- Murat, P, Zhong, J, Lekieffre, L et al 2014, 'G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation', Nature Chemical Biology, vol. 10, no. 5, pp. 358-364.
- Liang, B, Soka, M, Christensen, A et al 2014, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis', Journal of Molecular and Cellular Cardiology, vol. 67, pp. 69-76.
- Archer, S, Shirokikh, N & Preiss, T 2014, 'Selective and flexible depletion of problematic sequences from RNA-seq libraries at the cDNA stage', BMC Genomics, vol. 15, pp. 401.
- Clancy, JL, Patel, HR, Hussein, SMI et al 2014, 'Small RNA changes en route to distinct cellular states of induced pluripotency', Nature Communications, vol. 5, p. 5522.
- Hussein, SMI, Puri, MC, Tonge, PD et al 2014, 'Genome-wide characterization of the routes to pluripotency', Nature, vol. 516, no. 7530, pp. 198-206.
- Lee, D-S, Shin, J-Y, Tonge, PD et al 2014, 'An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator', Nature Communications, vol. 5, p. 5619.
- Tonge, PD, Corso, AJ, Monetti, C et al 2014, 'Divergent reprogramming routes lead to alternative stem-cell states', Nature, vol. 516, no. 7530, pp. 192-197.
- Vinuesa, CG & Preiss, T 2014, 'Inflammation: Gone with Translation', PLoS Genetics, vol. 10, no. 6, pp. e1004442
- Hentze, M & Preiss, T 2013, 'Circular RNAs: splicing's enigma variations', EMBO Journal, The, vol. 32, no. 7, pp. 923-925.
- Ohanian, M, Humphreys, D, Anderson, E et al 2013, 'A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance', BMC Genetics, vol. 14, no. 18, pp. 1-10.
- Olesen, M, Liang, B, Soka, M et al 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, vol. 34, no. 1, p. 642.
- Castello, A, Fischer, B, Hentze, M et al 2013, 'RNA-binding proteins in Mendelian disease', Trends in Genetics, vol. 29, no. 5, pp. 318-327.
- Li, C, Young, P, Maloney, C et al 2013, 'Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice', Epigenetics, vol. 8, no. 6, pp. 602-611.
- Lai, X, Beilharz, T, Au, W et al 2013, 'Yeast hEST1A/B (SMG5/6)- Like proteins contribute to environment-sensing adaptive gene expression responses', G3: Genes, Genomes, Genetics, vol. 3, no. 9, pp. 1649-1659.
- Sibbritt, T, Patel, H & Preiss, T 2013, 'Mapping and significance of the mRNA methylome', Wiley Interdisciplinary Reviews: WIREs RNA, vol. 4, no. 4, pp. 397-422.
- Hynes, C, Clancy, J & Preiss, T 2012, 'miRNAs in Cardiac Disease: sitting duck or moving target?', IUBMB Life, vol. 64(11), no. 11, pp. 872-878.
- Hernandez, G, Proud, C, Preiss, T et al 2012, 'On the diversification of the translation apparatus across eukaryotes', Comparative and Functional Genomics, vol. 2012, pp. 1-14.
- Gebauer, F, Preiss, T & Hentze, M 2012, 'From cis-regulatory elements to complex RNPs and back', Cold Spring Harbor Perspectives in Biology, vol. 4, no. 7, pp. 1-14.
- Castello, A, Fischer, B, Eichelbaum, K et al 2012, 'Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins', Cell, vol. 149, no. 6, pp. 1393-1406.
- Humphreys, D, Clancy, J, Patel, H et al. 2012, 'Complexity of Murine Cardiomyocyte miRNA Biogenesis, Sequence Variant Expression and Function', PLoS ONE, vol. 7, no. 2, pp. 1-18.
- Squires, J, Patel, H, Nousch, M et al 2012, 'Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA', Nucleic Acids Research, vol. 40, no. 11, pp. 5023-33.
- Clancy, J, Wei, G, Echner, N et al 2011, 'mRNA isoform diversity can obscure detection of miRNA-mediated control of translation', RNA, vol. 17, no. 6, pp. 1025-31.
- Squires, J & Preiss, T 2011, '5-methylcytosine as a modification in RNA', in J Craig & N Wong (ed.), Epigenetics: A Reference Manual, Horizonpress, USA, pp. 227-236.
- Li, C, Cropley, J, Cowley, M et al 2011, 'A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice', PLoS Genetics, vol. 7, no. 4, pp. e1001380.
- Beilharz, T & Preiss, T 2011, 'Polyadenylation state microarray (PASTA) analysis', in Castrillo JI & Oliver SG, (eds.), Methods in Molecular Biology: Yeast Systems Biology (vol 759), Springer, New York, pp. 133-148.
- Schonrock, N, Humphreys, D, Preiss, T et al 2011, 'Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-beta', Journal of Molecular Neuroscience, vol. 46, no. 2, pp. 324-335.
- Clancy, J & Preiss, T 2010, 'Getting to the heart of microRNA control of ribosome function', Australian Biochemist, vol. 41, no. 3, pp. 12-15.
- Squires, J & Preiss, T 2010, 'Function and detection of 5-methylcytosine in eukaryotic RNA', Epigenomics, vol. 2, no. 5, pp. 709-715.
- Swarbrick, A, Woods, S, Shaw, A et al 2010, 'miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma', Nature Medicine, vol. 16, no. 10, pp. 1134-1140.
- Larance, M, Rowland, A, Loehn, K et al 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, vol. 9, no. 4, pp. 682-94.
- Beilharz, T, Humphreys, D & Preiss, T 2010, 'miRNA effects on mRNA closed-loop formation during translation initiation', in Robert E. Rhoads (ed.), miRNA Regulation of the Translational Machinery, Springer-Verlag Berlin Heidelberg, London United Kingdom, pp. 99-112.
- Hentze, MW & Preiss, T 2010, 'The REM phase of gene regulation', Trends in Biochemical Sciences, vol. 35, no. 8, pp. 423-426.
- Schonrock, N, Ke, Y, Humphreys, D et al 2010, 'Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β', PLoS ONE (Public Library of Science), vol. 5, no. 6, pp. e11070.
- Beilharz, T, Humphreys, D, Clancy, J et al 2009, 'microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells', PLOS ONE (Public Library of Science), vol. 4, no. 8, pp. e6783, 12.
- Beilharz, T & Preiss, T 2009, 'Transcriptome-wide measurement of mRNA polyadenylation state', Methods, vol. 48, no. 3, pp. 294-300.
- Traven, A, Beilharz, T, Lo, T et al 2009, 'The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization in Saccharomyces cerevisiae', Genetics (online), vol. 182, no. 4, pp. 955-966.
- Zdanowicz, A, Thermann, R, Kowalska, J et al 2009, 'Drosophila miR2 primarily targets the 7GpppN cap structure for translational repression', Molecular Cell, vol. 35, no. 6, pp. 881-8.
- Humphreys, D, Westman, B, Martin, D et al 2008, 'Inhibition of translation initiation by a miRNA', in Appasani K (ed.), MicroRNAs: from Basic Science to Disease Biology, Cambridge University Press, UK, pp. 85-101.
- Butt, A, Sergio, C, Inman, C et al 2008, 'The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome', Breast Cancer Research (Online edition), vol. 10, no. 2, pp. R28.
- Beilharz, T & Preiss, T 2007, 'Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome', RNA, vol. 13, no. 7, pp. 982-97.
- Muckenthaler, M & Preiss, T 2007, 'Mechanismen der Translationskontrolle in Eukaryonten [Mechanisms of translational control in eukaryotes]', in Ruckpaul K and Ganten D (ed.), Mechanisms of translational control in eukaryotes, Springer, Heidelberg, pp. 139-158.
- Gao, L, Kwan, J, Macdonald, P et al 2007, 'Improved Poststorage Cardiac Function by Poly (ADP-ribose) Polymerase Inhibition: Role of Phosphatidylinositol 3-Kinase Akt Pathway', Transplantation, vol. 84, no. 3, pp. 380-6.
- Lackner, D, Beilharz, T, Marguerat, S et al 2007, 'A Network of Multiple Regulatory Layers Shapes Gene Expression in Fission Yeast', Molecular Cell, vol. 26, no. 1, pp. 145-155.
- Nousch, M, Reed, V, Bryson-Richardson, R et al 2007, 'The eIF4G-homolog p97 can activate translation independent of caspase cleavage', RNA, vol. 13, no. 3, pp. 374-84.
- Hentze, M, Gebauer, F & Preiss, T 2007, 'Cis-regulatory sequences and trans-acting factors in translation control', in Mathews MB, Sonenberg N, Hershey JWB (ed.), Translational Control in Biology and Medicine (2nd ed), Cold Spring Harbor Laboratory Press, New York, USA, pp. 269-295.
- Clancy, J, Nousch, M, Humphreys, D et al 2007, 'Methods to analyze microRNA-mediated control of mRNA translation', Methods in Enzymology, vol. 431, pp. 83-111.
- Clancy, JL, Nousch, M, Rodnina, M & Preiss, T. 2007. The ins and outs of translation. Genome Biology, vol. 8, p. 321.
- Muckenthaler, M & Preiss, T 2006, 'Translational Control in Eukaryotes', in Ruckpaul K and Ganten D (ed.), Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer, Heidelberg, pp. 1904-1909.
- Woolstencroft, R, Beilharz, T, Cook, M et al 2006, 'Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length', Journal of Cell Science, vol. 119, no. Pt24, pp. 5178-92.
- Westman, B, Beeren, L, Grudzien, E et al 2005, 'The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro', RNA, vol. 11, no. 10, pp. 1505-13.
- Humphreys, D, Westman, B, Martin, D et al 2005, 'MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 47, pp. 16961-6.
- BEILHARZ, T. H. & PREISS, T. 2004. Translational profiling: the genome-wide measure of the nascent proteome. Brief Funct Genomic Proteomic, 3, 103-11.
- PREISS, T. 2004. Functional genomics: strict tempo and hierarchical vocabularies. Genome Biol, 5, 307.
- BARON-BENHAMOU, J., FORTES, P., INADA, T., PREISS, T. & HENTZE, M. W. 2003. The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. RNA, 9, 654-62.
- PREISS, T. & HENTZE, M. W. 2003. Starting the protein synthesis machine: eukaryotic translation initiation. Bioessays, 25, 1201-11.
- PREISS, T., BARON-BENHAMOU, J., ANSORGE, W. & HENTZE, M. W. 2003. Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol, 10, 1039-47.
- DE GREGORIO, E., BARON, J., PREISS, T. & HENTZE, M. W. 2001. Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure. RNA, 7, 106-13.
- BERGAMINI, G., PREISS, T. & HENTZE, M. W. 2000. Picornavirus IRESes and the poly(A) tail jointly promote cap- independent translation in a mammalian cell-free system. RNA, 6, 1781-90.
- FORTES, P., INADA, T., PREISS, T., HENTZE, M. W., MATTAJ, I. W. & SACHS, A. B. 2000. The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol Cell, 6, 191-6.
- HEMMINGS-MIESZCZAK, M., HOHN, T. & PREISS, T. 2000. Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders. Mol Cell Biol, 20, 6212-23.
- DE GREGORIO, E., PREISS, T. & HENTZE, M. W. 1999. Translation driven by an eIF4G core domain in vivo. Embo J, 18, 4865-74.
- GEBAUER, F., CORONA, D. F., PREISS, T., BECKER, P. B. & HENTZE, M. W. 1999. Translational control of dosage compensation in Drosophila by Sex- lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail. Embo J, 18, 6146-54.
- PREISS, T. & HENTZE, M. W. 1999. From factors to mechanisms: translation and translational control in eukaryotes. Curr Opin Genet Dev, 9, 515-21.
- DE GREGORIO, E., PREISS, T. & HENTZE, M. W. 1998. Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent. RNA, 4, 828-836.
- LAFONTAINE, D. L., PREISS, T. & TOLLERVEY, D. 1998. Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Mol Cell Biol, 18, 2360-70.
- PREISS, T. & HENTZE, M. W. 1998. Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast. Nature, 392, 516-520.
- PREISS, T., MUCKENTHALER, M. & HENTZE, M. W. 1998. Poly(A)-tail-promoted translation in yeast: implications for translational control. RNA, 4, 1321-1331.
- PREISS, T., CHRZANOWSKA-LIGHTOWLERS, Z. M. & LIGHTOWLERS, R. N. 1997. Glutamate dehydrogenase: an organelle-specific mRNA-binding protein. Trends Biochem Sci, 22, 290.
- LIGHTOWLERS, R. N., SANG, A. E., PREISS, T. & CHRZANOWSKA-LIGHTOWLERS, Z. M. 1996. Targeting proteins to mitochondria: is there a role for mRNA localization? Biochem Soc Trans, 24, 527-31.
- PREISS, T., LOWERSON, S. A., WEBER, K. & LIGHTOWLERS, R. N. 1995. Human mitochondria: distinct organelles or dynamic network? Trends Genet, 11, 211-2.
- PREISS, T., SANG, A. E., CHRZANOWSKA-LIGHTOWLERS, Z. M. & LIGHTOWLERS, R. N. 1995. The mRNA-binding protein COLBP is glutamate dehydrogenase. FEBS Lett, 367, 291-6.
- CHRZANOWSKA-LIGHTOWLERS, Z. M., PREISS, T. & LIGHTOWLERS, R. N. 1994. Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcripts. J Biol Chem, 269, 27322-8.
- MOWS, C. C., PREISS, T., SLATER, E. P., CAO, X., VERRIJZER, C. P., VAN DER VLIET, P. C. & BEATO, M. 1994. Two independent pathways for transcription from the MMTV promoter. J Steroid Biochem Mol Biol, 51, 21-32.
- PREISS, T., CHRZANOWSKA-LIGHTOWLERS, Z. M. & LIGHTOWLERS, R. N. 1994. The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis. Biochim Biophys Acta, 1221, 286-9.
- SCHILLACE, R., PREISS, T., LIGHTOWLERS, R. N. & CAPALDI, R. A. 1994. Developmental regulation of tissue-specific isoforms of subunit VIa of beef cytochrome c oxidase. Biochim Biophys Acta, 1188, 391-7.
- CAO, X., PREISS, T., SLATER, E. P., WESTPHAL, H. M. & BEATO, M. 1993. Expression and functional analysis of steroid receptor fragments secreted from Staphylococcus aureus. J Steroid Biochem Mol Biol, 44, 1-11.
- MACKENZIE, K., HOWARD, J. A. K., MASON, S., GRAVETT, E. C., ASTIN, K. B., SHIXIONG, L., BATSANOV, A. S., VLAOVIC, D., MAHER, J. P., MURRAY, M., KENDREW, D., WILSON, C., JOHNSON, R. E., PREISS, T. & GREGORY, R., J. 1993. On intramolecular dyotropy: structural effects on reaction-rates, crystal structure-molecular mechanics correlations and primary deuterium kinetic isotope effects. J Chem Soc-Perkin Trans, 2, 1211-1228.
- PREISS, T. & LIGHTOWLERS, R. N. 1993. Post-transcriptional regulation of tissue-specific isoforms. A bovine cytosolic RNA-binding protein, COLBP, associates with messenger RNA encoding the liver-form isopeptides of cytochrome c oxidase. J Biol Chem, 268, 10659-67.
- PREISS, T., HALL, A. G. & LIGHTOWLERS, R. N. 1993. Identification of bovine glutamate dehydrogenase as an RNA-binding protein. J Biol Chem, 268, 24523-6.
