The Maddess Group - Diagnostics for Eye Diseases

JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites JCSMR Clinical Suites

My initial interest in the optical designs of invertebrate eyes led me to examine how visual systems squeeze real-time visual information into brains of very limited information capacity. My subsequent research into adaptive neural processing has lead to new glaucoma detection devices, the FDT and Matrix Perimeters, now being marketed by Carl Zeiss Meditec. Drs Corinne Carle and Josh van Kleef and I are now extending that work to provide objective non-contact perimetry using multifocal pupillography. The platform is now called the objectiveFIELD and is being developed with Konan Medical USA, we are being assisted by Dr Faran Sabeti of the School of Optometry and Visual Sciences at the University of Canberra. The objectiveFIELD has been shown to have value in Glaucoma, Diabetic Retinopathy, Macular Degeneration and Multiple Sclerosis.  Other recent work includes the adaptive dynamics of following eye movements; the processing of texture, and brightness; and methods for diagnosing neurological disorders.

JCSMR Clinical Suites

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Collaborators

  • Dr Nurliyana S Abdullah
  • Associate Professor Rohan W Essex
  • Professor Alicia Jenkins
  • Professor Christian J Lueck
  • Professor Chota Matsumoto
  • Professor Christopher J Nolan
  • Professor Yanti Rosli
  • Dr Faran Sabeti
  • Professor Jonathan D Victor
  • Dr Raymond Wong
  • Professor Paul S Bernstein
  • Professor Tailoi Chan-Ling
  • Dr Vincent Daria
  • Dr Jo Lane
  • Professor Michael G Morley

Leader

Researchers

Research support officers

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Project Status
Characterising 3D image structure Potential
Higher order image statistics and image texture Current
Multifocal pupillographic objective perimetry Current
Multifocal visual evoked potentials Current
The spatial frequency doubling illusion Current

Sabeti F, Lane J, Rohan E M F, Rai BB, Essex R W, McKone E and Maddess T. (2021). Central versus peripheral macular structure and function: acuity in age-related macular degeneration. Trans Vis Sci Tech 10: 2(10):1-12. DOI: /10.1167/tvst.10.2.10

Maddess T, Coy D, Herrington J, Carle CF, Sabeti F, Barbosa MS. (2021). Learning complex texture discrimination. J Optical Soc Am A38:449-455. DOI: 10.1364/JOSAA.413065

Rai BB, Ashby R, French A, Maddess T (2021) Rural-urban differences in Myopia prevalence among myopes presenting to Bhutanese retinal clinical services: a 3-year national study. Graefe’s Archive Ophthalmol. 259:613–621. DOI: /10.1007/s00417-020-04891-6.

Rai BB, Morely MG, Pema Z, Thukten T, Abi NK, Bernstein PS, Maddess T (2020). Retinal laser services in Bhutan: a 3-year national survey. BMC Ophthalmol. 20(404): 1-6. DOI: /10.1186/s12886-020-01675-8.

Rai BB, Morely MG, Pema Z, Thukten T, Abi NK, Bernstein PS, Maddess T (2020) Surgical management of vitreo-retinal diseases at the national referral hospital in Bhutan: a 3 year national study. New Frontiers Ophthalmol 6:1:5 DOI: 10.15761/NFO.1000251.

Abdullah SN, Sanderson GF, Husni MA, Maddess T. (2020) Insights for mfVEPs from perimetry using large spatial frequency-doubling and near frequency-doubling stimuli in glaucoma. Doc Ophthalmol; 141: 44-55. DOI: 10.1007/s10633-020-09750-7.

Rai BB, Morley MG, Berstein P, Maddess T. (2020) Pattern of vitreo-retinal diseases at the national referral hospital in Bhutan: a retrospective, hospital-based study. BMC Ophthalmol. 20(51): 1-11. DOI:10.1186/s12886-020-01335-x.

Rai BB, Sabeti F, Carle CF, Saraç Ö, Maddess T. (2020) Recovery dynamics of multifocal pupillographic objective perimetry from tropicamide dilation. Graefe’s Archive Ophthalmol. 258: 191-200. DOI:10.1007/s00417-019-04523-8

Rai BB, Shresthra MK, Thapa R, Essex RW, Govinda P, Maddess T. (2019) Pattern and presentation of vitreo-retinal diseases: lessons from a tertiary eye care centre in Nepal. Asia Pacific J Ophthalmol: 8(6), 481-488. DOI: 10.1097/01.APO.0000604400.50700.2d.

Barbosa MS, Maddess T, Ahn S, Chan-Ling T. (2019) Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age. Sci Reports. 9(13464). DOI:10.1038/s41598-019-49443-z.

Lane J, Mazlin J-L, Irons J, Rohan EMF, Sabeti F, Essex RW, Maddess T, Robbins RA, Gradden T, Dawel A, Smithson M, Barns N, He X, Crookes K, McKone E.  (2019) Caricaturing can improve facial expression recognition in low-resolution images and age-related macular degeneration. J Vision; 19(6): 18, 1-22.

Sabeti F, Carle CF, Jaros RK, Rohan EMF, Lueck CJ, Hughes D, Maddess T. (2019) Objective perimetry in sporting-related mild traumatic brain injury. Ophthalmology 126: 1053-1055. DOI: 10.1016/j.ophtha.2019.01.026

Pearce JG, Maddess T. (2019) The clinical interpretation of changes in intraocular pressure measurements using Goldmann applanation tonometry: a review. J Glaucoma 28(4): 302-306.

Loutit AJ, Shivdasani MN, Maddess T, Redmond SJ, Morley JW, Stuart GJ, Birznieks I, Vickery R, Potas JR. (2019) Peripheral nerves evoke reproducible signals with machine-learnable signal features in the dorsal column nuclei. Frontiers Sys Neurosci. 13(11): 1-19. DOI: 10.3389/fnsys.2019.00011

Carle CF, James AC, Rosli Y, Maddess T. (2019) Localization of neuronal gain control in the pupillary response. Frontiers Neurol 10(203): 1-9. DOI: 10.3389/fneur.2019.00203

Maddess T, Lueck CJ. (2019) Correlating structure with visual function in patients with multiple sclerosis: where is this leading? Clinical Neurophysiol 129: 157-159.

Nagai Y, Kito M, Maddess T. (2019) Photon reception and seeing light in squid eye. Kokushikan Centre Inform Sci. 40:1-9.

Lane J, Rohan EMF, Sabeti F, Essex RW, Maddess T, Dawel A, Robbins RA, Barnes N, He X, McKone E. (2018) Impacts of impaired face perception on social interactions and quality of life in age-related macular degeneration: A qualitative study and new community resources. PLoS ONE 13(12): e0209218.

Lane J, Rohan EMF, Sabeti F, Essex R, Maddess T, Barnes N, He X, Robbins R, Gradden T & McKone E. (2018). Improving face identity perception in age-related macular degeneration via caricaturing. Sci Reports 8(15205):1-10. DOI:10.1038/s41598-018-33543-3

Rosli Y, Carle CF, Ho Y, James AC, Kolic M, and Maddess T. (2018). Retinotopic effects of visual attention revealed by dichoptic multifocal pupillography. Sci Reports 8(2991): 1-13. DOI: 10.1038/s41598-018-21196-1

Nagai Y, Kito M, Maddess T. (2018). Analysis for cross-section of squid rhodopsin. Kokushikan Centre Inform Sci 39: 1-10

Numata T, Maddess T, Matsumoto C, Okuyama S, Hashimoto S, Nomoto H, and Shinomura Y. (2017). Exploring test-retest variability using high-resolution perimetry. Trans Vis Sci Tech 6(5) 8. DOI: 10.1167/tvst.6.5.8.

Maddess T, Daria V. (2017) To BCVA, or not to BCVA, that is the question. Clin Exp Ophthal 45(5): 437–439.

Loutit AJ, Maddess T, Redmond SJ, Morley JW, Stuart GJ & Potas JR. (2017). Characterisation and functional mapping of surface potentials in the rat dorsal column nuclei. J Physiol 59 A595(13): 4507-4524.

Sabeti F, James AC, Carle CF, Essex RW, Bell A & Maddess T. (2017). Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases. Sci Reports 7(45847): 1-12; DOI: 10.1038/srep45847.

Pearce JG, Maddess T (2017) Inter-visit test-retest variability of the Topcon 3D OCT-2000 in glaucoma. Optom Vis Sci 94: 404–410.

Nagai Y, Kito M, Maddess T. (2017) Estimation for energy transformation from retinal to rhodopsin in squid. Mem Kokushikan Cent Inform Sci 37: 1-8

Maddess T, Lueck CJ. (2017) Multiple sclerosis seen through new eyes. Editorial on Afferent visual pathways in multiple sclerosis: a review. Clin Exp Ophthal 45(1): 1-9.

Pearce JG, Maddess T. (2016) Retest variability in the Medmont M700 automated perimeter. Optom Vis Sci 93: 272-280.

Nagai Y, Kito M, Maddess T. (2016) Estimation for energy transformation from retinal to rhodopsin in squid. Mem Kokushikan Cent Inform Sci 37: 1-8.

Maddess T. (2015) Squiggly lines and wiggly data. Invest Ophth Vis Sci;56:7806.

Carle CF, James AC, Kolic K, Essex RW, Maddess T. (2015) Blue multifocal pupillographic objective perimetry in glaucoma. Invest Ophthalmol Vis Sci 56: 6394-6403.

Potas JRP, Gonçalves de Castro N, Maddess T, Nogueira de Souza M. (2015) Waveform similarity analysis: a simple template comparing approach for detecting and quantifying noisy evoked compound action potentials. PLoS ONE: DOI:10.1371/journal.pone.0136992.

Sabeti F, Nolan CJ, James AC, Jenkins A, Maddess T. (2015) Multifocal pupillography identifies changes in visual sensitivity according to severity of diabetic retinopathy in type 2 diabetes. Invest Ophthalmol Vis Sci 56: 4504-4513.

Reilly MA, Villareal A, Maddess T, Sponsel WE. (2015) Refined frequency doubling perimetry analysis reaffirms central nervous system control of chronic glaucomatous neurodegeneration. Trans Vis Sci Tech 4(3): DOI: 10.1167/tvst.4.3.7.

Sponsel WE, Maddess T, Reilly M. (2015) Definitive response to Denniss and Artes on: the paired eyes and brain in one person are one unit. Trans Vis Sci Tech 4(2): DOI: 10.1167/tvst.1164.1162.1168.

Seamons JWG, Barbosa MS, Bubna-Litic A, Maddess T. (2015) A lower bound on the number of mechanisms for discriminating fourth and higher order spatial correlations. Vision Res 108: 141–148

Nagai Y, Kito M, Maddess T. (2015) A vector analysis of squid retinal. Mem Kokushikan Cent Inform Sci 36: 1-8.

Carle CF, James AC, Kolic M, Essex RW & Maddess T. (2014). Luminance and colour variant pupillographic perimetry in glaucoma. Clin Exp Ophthalmol 42: 815-824.

Maddess T. (2014). Modelling the relative influence of fixation and sampling errors on test-retest-variability in perimetry. Graefes Archive Ophthalmol 252: 1611-1619.

Sabeti F, Essex RW, Maddess T, Saikal A, James AC & Carle CF. (2014). Multifocal pupillography in early age-related macular degeneration. Optom Vis Sci 91:904-915.

Barbosa M, Natoli R, Valter K, Provis J & Maddess T. (2014). Integral-geometry characterization of photobiomodulation effects on retinal vessel morphology. Biomed Opt Express 5: 2317-2332.

Ali EN, Maddess T, James AC, Voicu C & Lueck CJ. (2014) Pupillary response to sparse multifocal stimuli in multiple sclerosis patients.  Multiple Sclerosis J 20: 854-861.

Sponsel WE, Groth S, Satsangi N, Maddess T, Reilly M (2014) Refined data analysis provides clinical evidence for central nervous system control of chronic glaucomatous neurodegeneration. Trans Vis Sci Tech 3(3): 1-13.

Nagai Y, Kito M & Maddess T. (2014). Retinal location and structure in squid rhodopsin. Mem Kokushikan Cent Inform Sci 35: 19-23.

Abdullah SN, Sanderson G, James AC, Vaegan, Maddess T. (2014). Visual evoked potential and psychophysical contrast thresholds in glaucoma. Doc Ophthalmol 128: 111-121.

Barbosa M, Bubna-Litic A, Maddess T. (2013). Locally countable properties and the perceptual salience of textures. J Optical Soc Am A30:1688-1697.

Provis J, Dubis A, Maddess T & Carroll J. (2013). Adaptation of the central retina for high acuity vision: Cones, the fovea and the avascular zone. Prog Retin Eye Res 35: 63-81.

Sabeti F, James AC, Essex RW, Maddess T (2013) Multifocal pupillography identifies retinal dysfunction in early AMD. Graefes Archive Ophthalmol 251: 125-136.

Nagai Y, Kito M & Maddess T. (2013). Atomic configuration around retinal in squid rhodopsin. Mem Kokushikan Cent Inform Sci 34: 1-8.

Sabeti F, Maddess T, Essex RW & James AC. (2013). Dichoptic multifocal visual evoked potentials identify local retinal dysfunction in age-related macular degeneration. Doc Ophthal 126: 125-136.

Maddess T, Kolic M, Essex RW, Carle CF, James AC. (2013) High versus low density multifocal pupillographic objective perimetry in glaucoma Clinical Exp Ophthalmol 41: 140-147.

Carle CF, James AC, Maddess T. (2013) The pupillary response to color and luminance variant multifocal stimuli. Invest Ophthalmol Vis Sci 54: 467-475.

Nagai Y, Koto M & Maddess T. (2013). Distances among retinal atoms and rhodopsin atoms in squid optical receptor. Mem Kokushikan Cent Inform Sci 34; 43-50.

James AC, Kolic K, Bedford SM & Maddess T. (2012) Stimulus parameters for multifocal pupillographic objective perimetry. J Glaucoma 21:571-578.

Maddess T. (2012) Pupil dynamics and response amplitude. Invest Ophthalmol Vis Sci 53: 7644.

Abdullah SN, Aldahlawi N, Vaegan, Boon MY & Maddess T. (2012). Effect of contrast, region number and viewing distance on multifocal steady-state visual evoked potentials (MSVs). Invest Ophthalmol Vis Sci 53: 5527-5535.

Abdullah SN, Vaegan, Boon MY & Maddess T. (2012). Contrast-response functions of the multifocal steady-state VEP (MSV) Clinical Neurophysiology123: 1865-1871.

Rosli Y, Bedford SM, James AC, Maddess T. (2012) Photopic and scotopic multifocal pupillographic responses of in age-related macular degeneration. Vision Res 69:42-48

Maddess, T. (2012). Perimetry and retinal imaging. Expert Rev Ophthalmol 7: 109-111

Sabeti F, Maddess T, Essex RW & James AC. (2012) Multifocal pupillography identifies ranibizumab induced changes in retinal function for exudative age-related macular degeneration. Invest Ophthalmol Vis Sci 53: 253-260.

Sabeti F, Maddess T, Essex RW & James AC. (2011) Multifocal pupillographic assessment of age-related macular degeneration. Optom Vis Sci 88:1477-1485.

Carle CF, Maddess T, Kolic K, Essex RW, & James AC. (2011) Contraction anisocoria: segregation, summation and saturation in the pupil light reflex pathway. Invest Ophthalmol Vis Sci 52: 2365-2371.

Sabeti F, James AC, Essex RW, & Maddess T. (2011) Stimuli for objective macular perimetry. Vision Research. 51: 303-310.

Maddess T. (2011) FDT and parasol cells. Invest Ophthalmol Vis Sci 52: 3759.

Maddess T. (2011) The influence of sampling errors on test-retest variability in perimetry. Invest Ophthalmol Vis Sci 52: 1014-1022.

Carle CF, James AC, Kolic M, Loh Y, & Maddess T. (2011) High resolution multifocal pupillographic objective perimetry in glaucoma. Invest Ophthalmol Vis Sci 52: 2365-2371.

Nagai Y, Kito M, Kagawa H & Maddess T. (2011). A quantum chemical study of the retinal of squid rhodopsin. Mem Kokushikan Centre Inform Sci 32: 20-31.

Maddess T, Ho Y-L, Wong SSY, Kolic K, Goh X-L, Carle CF, James AC (2011) Multifocal pupillographic perimetry with white and colored stimuli J Glaucoma 20: 336-343.

 

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