The Lee Group - Optical Biofluidic Imaging Group
Discovering biological physics through optics, computing, materials and fluid dynamics.
Research themes
About
Our team works at the nexus of advanced imaging and biological physics. We achieve this by applying and inventing new optical techniques to precisely quantify the fundamental functions of biological systems.
Our current research focuses on understanding the different biofluidic properties in the extracellular domain that promote long-range cell-cell communications. We accomplish this by leveraging our multiscale, label-free imaging tools. Our research informs us of the subtle range of diverse combinations of biofluidic forces that complement biochemical signals in promoting multicellularity. The outcomes of our research aim to benefit tissue and biomaterial engineering, as well as the invention of new imaging technologies—now being commercialized by Ability Optics Pty Ltd.
Find out more about the Optical Biofluidic Imaging Group (OBIG) group on their website.
Google Scholar link - Woei Ming Steve Lee
Publications
Selected publications
- Junyu Liu, Yean Jin Lim... Woei Ming Lee | Nature Communications (2026) "Using rotational integration of oblique interferometric scattering to track axial spatiotemporal responses of tubular membrane protrusions"
- N D Bhattacharyya... Woei Ming Lee, P I. Croucher, T G Phan | Nature Protocols (2023) "Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone"
- Yujie Zheng, Yean Jin Lim... Woei Ming Lee | ACS Photonics (2022) "Combined Scattering, Interferometric, and Fluorescence Oblique Illumination for Live Cell Nanoscale Imaging"
- Tienan Xu, Hanqi Lin, Yean J. Lim... Woei Ming Lee | APL Photonics (2022) "Computational single-objective scanning light sheet (cSOLS)"
- Michelle M McDonald... Paul Timpson, Woei Ming Lee... Peter I Croucher, Tri Giang Phan | Cell (2021) ”Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption"
- Yujie Zheng, Samantha J. Montague, Yean J. Lim... Woei Ming Lee | Biophys J (2021) "Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro"
- Tienan Xu, Yean Jin Lim, Yujie Zheng... Woei Ming Lee | Lab On Chip (2020) "Modified inverted selective plane illumination microscopy for sub-micrometer imaging resolution in polydimethylsiloxane soft lithography devices"
- Zhiduo Zhang, Yujie Zheng, Tienan Xu... Woei Ming Lee | Biomed. Opt. Express (2020) "Holo-UNet: hologram-to-hologram neural network restoration for high fidelity low light quantitative phase imaging of live cells"
- Jun Ki Kim, Woei Ming Lee et al. | Nature Protocols (2012) ”Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals”
- Woei Ming Lee et al. | Nature Protocols (2007) "Construction and calibration of an optical trap on a fluorescence optical microscope"
Projects
Members
Leader
Group Leader
Researcher
Senior Imaging Scientist
Senior Tutor
Visiting Fellow
Visiting Scientist, Ability Optics Pty Ltd
Visiting Scientist
CEO, Ability Optics Pty Ltd
Visitor
Campus Visitor from Petersime
Visiting Postdoctoral Fellow
Visiting Technical Consultant - CTO Ability Optics Pty Ltd
Student
PhD Student
PhD Student
News
ANU scientists have adapted the tech behind LCD screens to steer light inside microscopes, so they can watch many tiny cell parts move at once. This faster, sharper view helps reveal how cells work, how they talk to each other, and how diseases like cancer grow and spread.
ANU spinoff company Ability Optics Pty Ltd is accelerating to revolutionise biotechnology with an aim to speed up early lead drug screening by 100-fold.
The Centre for Computational Biomedical Sciences (CCBS) is on a mission to usher in a new era of biomedical discovery through computational innovation.