My laboratory adopts a multi-pronged real time volumetric imaging approaches to quantitatively assess biological dynamics at cellular and sub-cellular level, in vitro (biomicrofluidics) and in vivo (living animals) studies under pathological conditions.
His current work focus on developing and applying optical tools to study biological fluidic flows in vasculature, microfluidics and in the interstitial space. Lee Lab focus on measurement tools that can measure physical traits behind tissue remodelling that is modulated by biological fluidic transport systems e.g. interstitial fluidic transport within the extracellularmatrix (ECM) and platelet aggregates.
Research support officer
"Modified inverted selective plane illumination microscopy for sub-micrometer imaging resolution in polydimethylsiloxane soft lithography devices" Lab On Chip (2020)
"Imaging platelet processes and function-current and emerging approaches for imaging in vitro and in vivo” Front. Immunol. (2020)
"Advanced Optical Imaging of Blood Thrombus", European Physical Journal (Web Conf) (2019) - Invited talk at European Optical Society
"Quantifying embolism: label free volumetric mapping of thrombus structure and kinesis in a microfluidic system with optical holography" Advanced Biosystems (2018)
"Optical toolkits for in vivo deep tissue laser scanning microscopy: a primer", Journal of Optics (2018)
"Flexible polygon-mirror based laser scanning microscope platform for multiphoton in-vivo imaging” J of Biophotonics (2017)
"In vivo cellular imaging of internal organs in small animals with GRIN fluorescence endomicroscopy: from fabrication to imaging” Nature Protocols (2012)