Research projects

We aim to investigate the evolutionary relationships between endogenous and exogenous retroviruses to understand how retroviruses originated and diversified.

We aim to understand how ancient retrovirus-like elements persist and propagate in marine animals despite host genome defence mechanisms.

We aim to investigate how Drosophila eugracilis maintains transposon silencing without ping-pong amplification and how its piRNA pathway has evolved.

We aim to identify how PIWI proteins regulate target mRNAs to control intestinal stem cell proliferation and tumour growth.

We aim to investigate how transposon activity and piRNA-mediated defence influence ovarian development and egg-chamber formation.

We aim to uncover the molecular mechanisms that control the timing of splicing during transcription.

670nm Red Light as a treatment for Retinopathy of Prematurity (Phase 1 Clinical Trial)

This project focuses on how germ cells control the function of Sertoli cells.

The broader goals of the project include facilitating the exploration of the RNA interactome for researchers and suggesting potential therapeutic interventions for diseases where RNA dysfunction is a significant factor, such as in cancers and genetic disorders.

This study aims to identify and understand mechanisms of intrinsic and acquired resistance to RNA Polymerase I (Pol I) inhibition in cancer, with the goal of developing strategies to overcome resistance to Pol I inhibitors.

This project investigates antibacterial activites of newly developed biomaterials.

This project includes cellular immunology techniques, bioinformatics and biophysical techniques.

Brain tumour models

Cancer Stem Cell Models

This project aims to develop and apply artificial intelligence and causal inference techniques to the analysis of routinely collected clinical and administrative health datasets.