Projects

Find all JCSMR research projects.

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Characterization of H2A.Lap1 KO mice spermatogenesis following heat stress or gamma irradiation. Current
Elucidate the role of testis-specific histone variant expression in the Purkinje neurons of mouse cerebellum Current
Gene regulation in human neutrophils from patients with systemic vasculitis Current
5-methylcytosine as an epitranscriptomic mark Current
670nm Red Light as a treatment for Retinopathy of Prematurity (Phase 1 Clinical Trial) Current
A longitudinal study of depression, anxiety, substance use and cognitive change: PATH Through Life Current
A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants Current
A novel mechanism of long-term memory formation that involves testis-specific histone variant expression in the brain Current
A novel role for the pol I transcription factor UBF in the regulation of expression of histone gene clusters and cellular DNA damage responses Current
Abnormal brain development in a rat model of Hirschsprung's disease Current
Application of Bayesian modelling of high-throughput genomic data to obtain robust and interpretable estimates of model parameters Current
B cell responses to malaria Current
Brain tumour models Current
Calcium imaging of presynaptic terminals Current
Cancer Stem Cell Models Current
Characterising the function of general transcription elongation factor Paf1 complex in transposon defence Current
Chromatin and RNA surveillance Current
Circuit mapping in the piriform cortex using optogenetics Current
Consequences of impaired neuronal activity during development in a mouse model of autism Current
Defining the biological role, regulation and signalling mechanism for IL-5 Current
Determining synaptic properties in small networks of neurons Current
Develop and characterise inhibitors of various histone-mediated pathologies Potential
Developing new avenues for the treatment of Hodgkin lymphoma and other blood cancers Current
Development of a molecular tool for personalised cancer treatment – a synthetic biology approach Current
Development of CRISPR/Cas9 genome editing technology Potential

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