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The Man Group investigates the role of inflammation in infectious diseases and cancer. Pattern-recognition receptors are innate immune sensors which detect pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). These receptors activate signalling pathways and mediate the production of inflammatory cytokines, type I interferons and other anti-microbial molecules. We study the mechanisms by which host sensors recognise bacteria, viruses and parasites, and explore how these sensors shape the overall immune response to infection.

We investigate the role of disease-fighting immune proteins in destroying multidrug resistant pathogens. We also study how uncontrolled inflammation can be targeted by immunotherapies to prevent the development of cancer, autoimmunity and infectious diseases.

We welcome applications from undergraduate, Honours and PhD students, and research assistants and Postdoctoral fellows. E-mail the Group Leader Professor Si Ming Man (siming.man@anu.edu.au) for further information regarding project details and position availability.