This project aims to investigate the role of APA in cell fate by studying CD8+ T cells that respond to virus infections and how RNA-binding proteins (RBPs) regulate APA in T cell differentiation.

Role of miRNA in retinal degeneration

A multitude of brain cancer (glioma) mutations, identified by large-scale next generation sequencing (NGS), are predicted to drive disease through computational algorithms in silico.

This project develops Spatial Adaptive Imaging (SAI) technologies to image millions of single cells in one high-resolution image, surpassing current single cell and microscopy techniques.

This study investigates how UBF isoforms remodel ribosomal DNA (rDNA) chromatin, aiming to elucidate their impact on chromatin dynamics and gene regulation.

This project is based on cellular immunology techniques such as flow cytometry or intravital imaging.

This study assesses the potential of second-generation RNA Polymerase I inhibitors as therapeutic agents for cancer by evaluating their ability to inhibit cancer cell growth and proliferation.

We investigate the neuro-protective benefits of different forms of exercise to retinal health and aim to understand what molecular processes mediate this.Our ongoing projects aim to determine whether or not these benefits can be translated into therapeutic approaches for retinal diseases such as AMD.

We've discovered that platelets help remove aged red blood cells by forming complexes that target them for destruction in the spleen, a process crucial for preventing thrombosis and maintaining red blood cell homeostasis.

The long-term goal of this project is to understand the interplay between chromatin modifications, nucleosome-positions, -turnover and -occupancy, and perhaps other as yet unknown chromatin characteristics, that allow the dynamic regulation of the eukaryotic genome.

The role of oxidative stress in the progression of retinal degenerations

An exciting and novel development in the field of DNA-repair. Our mid-to long-term research goals will focus on the molecular mechanism behind this finding both in the fission yeast S. pombe and in mammalian cells. Findings have also identified potential new targets for cancer treatments.

This project aims to shed light on the role of APA and its regulation by RNA-binding proteins (RBPs) in the retina, with a particular focus on responses to oxidative stress as observed in AMD.