Professor Leonie Quinn
Head, Division of Genome Sciences and Cancer
PhD
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About
After completing her PhD studies in Adelaide (1999) and conducting postdoctoral research at the Peter MacCallum Cancer Centre (2000-2007), Dr Quinn established her laboratory at the University of Melbourne in 2007. In 2016 Dr Quinn relocated to The John Curtin School of Medical Research (ANU, Canberra) to establish the Quinn Group - Cancer Models in the ACRF Department of Cancer Biology and Therapeutics.
Affiliations
Groups
Research interests
Dr Quinn’s research uses Drosophila molecular genetic approaches to determine how transcriptional networks integrate extra- and intracellular signalling inputs to drive tissue growth. Deciphering pathways controlling growth during normal development provides an avenue to understanding dysregulation of these networks in cancer.
Areas of expertise
- Cell And Nuclear Division
- Gene Expression (Incl. Microarray And Other Genome Wide Approaches)
- Genetics
- Cancer Cell Biology
- Cell Development, Proliferation And Death
- Developmental Genetics
Projects
- Brain tumour models, Supervisor
- Cancer Stem Cell Models, Supervisor
- Leukemia Models, Supervisor
- Mini-brain systems to identify novel treatments for brain cancer, Supervisor
- Solving mysteries of the neural stem cell niche to understand brain cancer, Supervisor
- Transcriptional control of the MYC oncogene, Supervisor
Location
Room 3.34
Publications
Recent Selected Publications
- O. Zaytseva, N.C. Mitchell, D. Muckle, C. Delandre, Z. Nie, J.K. Werner, J.T. Lis, E. Eyras, R.D. Hannan, D.L. Levens, O.J. Marshall, L.M. Quinn, Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors, Development 150 (2023). https://doi.org/10.1242/dev.201563. (5YIF: 7.8)
- Olga Zaytseva, Naomi Mitchell, Linna Guo, et al., Leonie Quinn. Transcriptional repression of Myc underlies AGO1's tumour suppressor function. Development 2020, 147: dev190231 doi: 10.1242/dev.190231. June issue “Research Highlight" and “People Behind the Papers” feature interview (5YIF: 7.8)
- Nick Lim et al., Leonie Quinn. Glial-specific functions of microcephaly protein WDR62, and interaction with the mitotic kinase AURKA, are essential for Drosophila brain growth. Stem Cell Reports 2017 v9 (1), p32-41 (5YIF 7.7). Feature Article “Medical Express” microcephaly-brain-size-linked-mutation
- Linna Guo, Olga Zaysteva, Naomi Mitchell et al., Leonie Quinn. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the Mediator Complex to modulate MYC transcription and tissue growth. Nucleic Acids Research 2016 doi.org/10.1093/nar/gkw461 (5YIF 17.16)
- Amanda Lee, Naomi Mitchell et al., Leonie Quinn. Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models. Nature Communications 2015 doi:10.1038/ncomms8404 (5YIF 17)
- Naomi Mitchell, et al., Leonie Quinn. Hfp inhibits Drosophila MYC transcription and cell growth in a TFIIH/Hay-dependent manner Development 2010 137 (17): 2875-2884 (5YIF: 7.8)