Quantitative measurement of multicellularity is a rapidly evolving field with significant implications for understanding biological systems, disease progression, and therapeutic development. The core idea is to obtain comprehensive label free nanoscopic to microscopic structural information on how single cells form multicellular structures and their dynamics across various spatial and temporal scales. Along with genetic and protein profiling, this aids our deep understanding of how cells interact within a tissue (micro-scale) and can inform how the entire organ functions (macro-scale).