Single cell technologies have emerged as a multi-billion-dollar industry that has grown by approximately $300 million in the last 12 months to $2.9 billion. A major challenge of all single cell technologies is the requirement to perform tissue dissociation to isolate large populations of single cells from whole tissue. This project generates a new class of Spatial Adaptive Imaging (SAI) technologies that surpass single cell and imaging microscopy techniques to image up to millions of single cells in one image, with the highest resolution.