Research projects

RNA Sequencing with Oxford Nanopore Technologies produces a stream of signals that can be decoded to uncover the properties of individual molecules.

We engineer programmable RNA systems that activate gene expression only in target cells by embedding sensing and logic directly within mRNAs. Using ribozyme-based RNA switches, we create self-activating mRNA platforms that enable precise, cell-specific control of gene expression for biomedical applications.

Quantitative studies of the presentation of viral antigens to the immune system (especially CD8+ T cells) during infection.

Major questions about the molecular mechanisms of rapid stress adaptation remain unanswered.

This project will examine the function of the variety of amino acid transporters found in neuronal tissue.

This project aims to investigate the role of APA in cell fate by studying CD8+ T cells that respond to virus infections and how RNA-binding proteins (RBPs) regulate APA in T cell differentiation.

Role of miRNA in retinal degeneration

This project will focus on the development of microsimulation models and optimisation tools that integrate AI algorithms to evaluate clinical and economic outcomes in population health.

A multitude of brain cancer (glioma) mutations, identified by large-scale next generation sequencing (NGS), are predicted to drive disease through computational algorithms in silico.

This study investigates how UBF isoforms remodel ribosomal DNA (rDNA) chromatin, aiming to elucidate their impact on chromatin dynamics and gene regulation.

This project is based on cellular immunology techniques such as flow cytometry or intravital imaging.

This study assesses the potential of second-generation RNA Polymerase I inhibitors as therapeutic agents for cancer by evaluating their ability to inhibit cancer cell growth and proliferation.

We investigate the neuro-protective benefits of different forms of exercise to retinal health and aim to understand what molecular processes mediate this.Our ongoing projects aim to determine whether or not these benefits can be translated into therapeutic approaches for retinal diseases such as AMD.