670nm Red Light as a treatment for Retinopathy of Prematurity (Phase 1 Clinical Trial)

This project focuses on how germ cells control the function of Sertoli cells.

The broader goals of the project include facilitating the exploration of the RNA interactome for researchers and suggesting potential therapeutic interventions for diseases where RNA dysfunction is a significant factor, such as in cancers and genetic disorders.

This study aims to identify and understand mechanisms of intrinsic and acquired resistance to RNA Polymerase I (Pol I) inhibition in cancer, with the goal of developing strategies to overcome resistance to Pol I inhibitors.

This project investigates antibacterial activites of newly developed biomaterials.

This project includes cellular immunology techniques, bioinformatics and biophysical techniques.

Brain tumour models

Cancer Stem Cell Models

This study explores how dynamic changes in ribosomal DNA (rDNA) chromatin contribute to cancer development, aiming to uncover mechanisms of malignant transformation and potential therapeutic targets.

This project focuses on the role of H2A.B in spermatogenesis under heat stress.

This project focuses on novel morphometric analysis methods for emerging types of 3D image data.

Our research focuses on inhibiting nucleic acid sensing receptors or signaling pathway molecules to prevent autoantibody production and autoimmune pathology in autoimmune mouse models, in collaboration with the Gantier Group at the Hudson Institute of Medical Research.

We aim to genetically identify positive and negative interactors of hyrax to begin to unravel the function of Paf1 complex in the transposon defence in the germline.

Although only a small percentage of our genome consists of protein coding genes, the majority of the genome is transcriptionally active, resulting in significant quantities of non-coding RNA (ncRNA) transcripts. We are studying the co-transcriptional recruitment of RNA binding complexes to the nascent transcripts.