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Tissue specific factors of Th17cell mediated autoimmunity Current
To determine the role of histone variants, and other important epigenetic regulators, in regulating gene transcription and splicing by performing high-resolution nucleosome mapping and structure experiments. Potential
To elucidate the role of the epigenome, including the histone variant H2A.Z, in regulating the 3-dimensional architecture of the genome by inhibiting the expression of epigenetic regulators cellular differentiation Potential
To study the role of histone variants and other epigenetic regulators in controlling pre-mRNA splicing on brain function and spermatogenesis using mouse knockout models. Potential
Tracking ribosome footprints to reveal the intricacy and control of translation Potential
Transcriptional control of the MYC oncogene Current
Translational control in cancer. Current
Uncover the mechanism of novel splicing “rescue” pathways Current
Uncovering the roles of viral and host genes in viral pathogenesis Potential
Understand the IL-4/ IL-13 molecular mechanisms governing the induction of high avidity T and B cell immunity Current
Understanding B cell development - The role of SPPL2A on B cell survival Current
Understanding herpes simplex virus latency Potential
Unravelling the role of transposon defence pathway in the development of gonads. Current
Use live animal imaging technologies to assess vaccine safety and uptake Current
Why do live pathogens make better vaccines? Potential