Characterising novel Inhibitors that prevent production of autoantibodies
Our research focuses on inhibiting nucleic acid sensing receptors or signaling pathway molecules to prevent autoantibody production and autoimmune pathology in autoimmune mouse models, in collaboration with the Gantier Group at the Hudson Institute of Medical Research.
Research themes
Project status
Content navigation
About
A hallmark of autoimmune diseases such as SLE is the production of antibodies that target nuclear antigens – termed antinuclear antibodies. Our laboratory has a number of autoimmune mouse models that have genetic defects similar to those found in autoimmune patients. Through a collaborative partnerships with the Gantier Group at the Hudson Institute of Medical Research in Melbourne, this research project will harness novel inhibitors that target either nucleic acid sensing receptors or signalling pathway molecules and examine their efficacy in vivo to prevent the generation of autoantibodies and autoimmune pathology in our autoimmune mouse models.