This project focuses on how germ cells control the function of Sertoli cells.

Brain tumour models

Cancer Stem Cell Models

This project focuses on the role of H2A.B in spermatogenesis under heat stress.

We aim to genetically identify positive and negative interactors of hyrax to begin to unravel the function of Paf1 complex in the transposon defence in the germline.

Although only a small percentage of our genome consists of protein coding genes, the majority of the genome is transcriptionally active, resulting in significant quantities of non-coding RNA (ncRNA) transcripts. We are studying the co-transcriptional recruitment of RNA binding complexes to the nascent transcripts.

Generating a molecular tool that can distinguish between cancer cells and non-cancer cells by detecting specific mutations in the genome, and eliminating cancer cells very specifically, without the strong side-effects of current cancer treatments.

The aim of this project is to better understand how the bacteria defend against viral infection and how we can take advantage of the bacteria defence system to harness it as a gene editing technology.

While there is no perfect model to simulate all the pathologies associated with human AMD, we use a growing number of approaches to better understand the progression of AMD and retinal degenerations in general. These models also serve to test the efficacy of novel AMD therapeutic and diagnostic pipelines.

Exosomes are paramount to the pathogenesis of a plethora of neurodegenerative diseases but their role in retinal degenerations remains largely unknown. At the Clear Vision Research Lab we study exosomes using several miRNA-centered approaches.

This project uses next generation sequencing (NGS) and mass spectrometry to investigate the possible existence of regulatory interactions between ribonucleic acids, enzymes and metabolites to connect gene expression and metabolism

This project focuses the role of H2A.B in Hodgkin Lymphoma.

We wish to address gaps in capability by using accurate read-outs of translation efficiency available to us and developing methods for parallel extraction of structural, isoform and RNA-binding protein positional data, together with ligand-specific ribosome localisation read-outs.

This project focuses on Cancer/Testis (C/T) antigens and their function.

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This project focuses on the role of the histone variant H2A.B3 on spermatogenesis.

Leukemia Models

Despite only being discovered as recently as the turn of this century, miRNAs are already used in clinical trials as therapeutic candidates for complex diseases. Our research aims to characterise key miRNAs in the retina and exploit those as therapeutic molecules in the retina.

We aim to identify the causative molecular defects to investigate the function of small RNA trimming outside of germline.

Novel computational methods for long-read sequencing