670nm Red Light as a treatment for Retinopathy of Prematurity (Phase 1 Clinical Trial)

The broader goals of the project include facilitating the exploration of the RNA interactome for researchers and suggesting potential therapeutic interventions for diseases where RNA dysfunction is a significant factor, such as in cancers and genetic disorders.

Brain tumour models

Cancer Stem Cell Models

This project aims to develop and apply artificial intelligence and causal inference techniques to the analysis of routinely collected clinical and administrative health datasets.

We aim to genetically identify positive and negative interactors of hyrax to begin to unravel the function of Paf1 complex in the transposon defence in the germline.

We investigate how cell-cell communication, adhesion, fluid flow, and microstructure control cell migration and tissue formation in response to dynamic extracellular conditions.

We're developing PDIP, a peptide derived from PF4, to combat malaria by targeting and killing parasites inside infected cells; current efforts focus on optimizing its structure and combining it with existing drugs for enhanced efficacy.

Our goal is to harness extensive single-cell and spatial transcriptome datasets to decipher APA/AS patterns and gene expression simultaneously, expanding the scope beyond conventional single-cell expression analysis.

While there is no perfect model to simulate all the pathologies associated with human AMD, we use a growing number of approaches to better understand the progression of AMD and retinal degenerations in general. These models also serve to test the efficacy of novel AMD therapeutic and diagnostic pipelines.

This project advances the development of innovative machine learning models designed to unearth conserved cis-regulatory RNA structures across vertebrate genomes. This initiative includes the creation of new RNA structure 2D/3D modeling and comparative genomics methods, underpinned by robust neural network architectures.

Exosomes are paramount to the pathogenesis of a plethora of neurodegenerative diseases but their role in retinal degenerations remains largely unknown. At the Clear Vision Research Lab we study exosomes using several miRNA-centered approaches.

A number of our research projects seek to understand how ribosomal biogenesis controls thrombopoiesis.