This study investigates how UBF isoforms remodel ribosomal DNA (rDNA) chromatin, aiming to elucidate their impact on chromatin dynamics and gene regulation.

This project is based on cellular immunology techniques such as flow cytometry or intravital imaging.

This study assesses the potential of second-generation RNA Polymerase I inhibitors as therapeutic agents for cancer by evaluating their ability to inhibit cancer cell growth and proliferation.

To determine the role of histone variants, and other important epigenetic regulators, in regulating gene transcription and splicing.

To elucidate the role of the epigenome, including the histone variant H2A.Z, in regulating the 3-dimensional architecture of the genome by inhibiting the expression of epigenetic regulators cellular differentiation.

To study the role of histone variants and other epigenetic regulators in controlling pre-mRNA splicing on brain function and spermatogenesis using mouse knockout models. In addition, how the regulation of splicing impacts the progression of cancer using human breast cell lines.

This project combines NGS technology with isolation of polyribosomal complexes from living cells, to generate transcriptome-wide snapshots of the distribution of translation complexes along mRNAs

This includes studies of genes of vaccinia virus that might be an impediment to use of this virus as a vaccine vector, genes of herpes simplex virus that block antigen presentation and genes involved in effective host responses.

We have a particular interest in viral and host gene expression during the latent phase of infection.

We utilise a unique mouse model to explore the interaction between genetic predisposition and environmental factors in promoting autoimmune disease development, particularly in SLE research.

Our projects use genomics, cellular immunology, and transcriptomics to uncover the unique causes of chronic disease in Indigenous Australians, aiming to identify new treatment targets and improve community health outcomes.

Our project explores novel antimicrobial peptides inspired by the immune system to understand their mechanism in combating antibiotic-resistant bacteria.

Our projects use advanced genomics, cellular immunology, and transcriptomics to investigate the unique causes of immune diseases in individuals, aiming to identify new treatment targets and improve patient outcomes.