Tracking ribosome footprints to reveal the intricacy and control of translation

This project combines NGS technology with isolation of polyribosomal complexes from living cells, to generate transcriptome-wide snapshots of the distribution of translation complexes along mRNAs

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This project is open for Honours, Masters and PhD students.
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Potential
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Contact name
Professor Thomas Preiss
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About

Messenger ribonucleic acids (mRNA) act as templates for protein synthesis by ribosomes. Much like the DNA of genes, eukaryotic mRNA molecules do not exist as naked nucleic acid. They interact with RNA-binding proteins, ribosomes and translation factors, and adopt dynamic structures that determine the precise outcome of translation. We combine NGS technology with isolation of polyribosomal complexes from living cells, to generate transcriptome-wide snapshots of the distribution of translation complexes along mRNAs. Such systems-level data will allow unprecedented insight into the mechanism, dynamics and regulation of protein synthesis.

For more information:

https://researchers.anu.edu.au/researchers/preiss-t

Members

Supervisor

Thomas Preiss SDCRI RNA

Centre Director, The Shine-Dalgarno Centre for RNA Innovation
Director, National Therapeutic mRNA Platform
Group Leader
Professor

Nikolay Shirokikh

NHMRC Investigator Grant