The broader goals of the project include facilitating the exploration of the RNA interactome for researchers and suggesting potential therapeutic interventions for diseases where RNA dysfunction is a significant factor, such as in cancers and genetic disorders.

We aim to genetically identify positive and negative interactors of hyrax to begin to unravel the function of Paf1 complex in the transposon defence in the germline.

Our goal is to harness extensive single-cell and spatial transcriptome datasets to decipher APA/AS patterns and gene expression simultaneously, expanding the scope beyond conventional single-cell expression analysis.

While there is no perfect model to simulate all the pathologies associated with human AMD, we use a growing number of approaches to better understand the progression of AMD and retinal degenerations in general. These models also serve to test the efficacy of novel AMD therapeutic and diagnostic pipelines.

Exosomes are paramount to the pathogenesis of a plethora of neurodegenerative diseases but their role in retinal degenerations remains largely unknown. At the Clear Vision Research Lab we study exosomes using several miRNA-centered approaches.

A number of our research projects seek to understand how ribosomal biogenesis controls thrombopoiesis.

We wish to address gaps in capability by using accurate read-outs of translation efficiency available to us and developing methods for parallel extraction of structural, isoform and RNA-binding protein positional data, together with ligand-specific ribosome localisation read-outs.

Our research laboratory is dedicated to the in-depth exploration of the intricate interplay among platelet receptors, metalloproteases, and the surrounding plasma microenvironment.

Despite only being discovered as recently as the turn of this century, miRNAs are already used in clinical trials as therapeutic candidates for complex diseases. Our research aims to characterise key miRNAs in the retina and exploit those as therapeutic molecules in the retina.

We aim to identify the causative molecular defects to investigate the function of small RNA trimming outside of germline.

This project aims to obtain comprehensive label free nanoscopic to microscopic structural information on how single cells form multicellular structures.

Novel computational methods for long-read sequencing