This project investigates antibacterial activites of newly developed biomaterials.

This project includes cellular immunology techniques, bioinformatics and biophysical techniques.

Our research focuses on inhibiting nucleic acid sensing receptors or signaling pathway molecules to prevent autoantibody production and autoimmune pathology in autoimmune mouse models, in collaboration with the Gantier Group at the Hudson Institute of Medical Research.

We investigate cytokine roles in SLE and opportunities for projects studying their impact on autoreactive B cell survival, focusing on identified genetic variants and therapeutic targets.

We're developing PDIP, a peptide derived from PF4, to combat malaria by targeting and killing parasites inside infected cells; current efforts focus on optimizing its structure and combining it with existing drugs for enhanced efficacy.

We've identified genetic factors contributing to kidney disease in the Australian Indigenous population and are creating mouse models and cell lines to study these genes and test potential treatments.

Our project investigates a novel DNA sensor's role in preventing cell proliferation and colorectal cancer by modulating immune responses and inflammation.

Our project aims to identify how immune receptors and inflammasomes contribute to liver cancer development and potential therapies targeting these pathways to mitigate chronic inflammation and liver injury.

Our project investigates novel NLRP3 inhibitors to understand their efficacy in human cells and preclinical models of chronic inflammatory diseases.

This project investigates miRNA profiles in human trabecular bone, synovial fluid and plasma sourced from total join replacement revision surgery, to develop better markers, treatments and prevention strategies.

This project is based on cellular immunology techniques such as flow cytometry or intravital imaging.

We've discovered that platelets help remove aged red blood cells by forming complexes that target them for destruction in the spleen, a process crucial for preventing thrombosis and maintaining red blood cell homeostasis.

The McMorran group discovered that platelets play a protective role in malaria by releasing Platelet factor 4 (PF4), which kills the parasite, and are currently studying the molecular mechanisms behind this function.

We utilise a unique mouse model to explore the interaction between genetic predisposition and environmental factors in promoting autoimmune disease development, particularly in SLE research.

Our projects use genomics, cellular immunology, and transcriptomics to uncover the unique causes of chronic disease in Indigenous Australians, aiming to identify new treatment targets and improve community health outcomes.

Our project explores novel antimicrobial peptides inspired by the immune system to understand their mechanism in combating antibiotic-resistant bacteria.

Our projects use advanced genomics, cellular immunology, and transcriptomics to investigate the unique causes of immune diseases in individuals, aiming to identify new treatment targets and improve patient outcomes.

The aim of this project is to replicate the protection induced by a live pathogen with a safe subunit construct.