Hepatocellular carcinoma or liver cancer is a leading cause of cancer-related death worldwide and in Australia. Chronic or excessive inflammation and liver injury are major risk factors of liver cancer. Inflammation is triggered by immune receptors and there are hundreds of them in the human body. These immune receptors detect or recognise specific patterns found on cancer cells. In this new project, we will identify the function of immune receptors and inflammasomes in triggering or preventing liver cancer. Understand the biology of immune receptors will help develop drugs or therapies that change the way these immune receptors work, and in doing so, help fight against cancer; for example, stopping immune receptors from initiating chronic or excessive inflammation in our body.