Projects
Our research laboratory is dedicated to the in-depth exploration of the intricate interplay among platelet receptors, metalloproteases, and the surrounding plasma microenvironment.
This project focuses on the role of the histone variant H2A.B3 on spermatogenesis.
Student intake
Open for Honours, PhD students
Status
Potential
People
- Associate Professor Tanya Soboleva, Supervisor
A multitude of brain cancer (glioma) mutations, identified by large-scale next generation sequencing (NGS), are predicted to drive disease through computational algorithms in silico.
Student intake
Open for Honours, PhD students
Status
Current
People
- Professor Leonie Quinn, Supervisor
This project aims to obtain comprehensive label free nanoscopic to microscopic structural information on how single cells form multicellular structures.
Student intake
Open for Masters, PhD students
Status
Current
People
- Andrew Waddell, Researcher
- Dr Klaus Metzger, Researcher
- Dr Woei Ming (Steve) Lee, Principal investigator
- Dr Yean Jin (Daniel) Lim, Researcher
Novel computational methods for long-read sequencing
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Professor Eduardo Eyras, Principal investigator
Investigating the role of Spindle-E Zinc Finger motif in piRNA ping-pong biogenesis
RNA Sequencing with Oxford Nanopore Technologies produces a stream of signals that can be decoded to uncover the properties of individual molecules.
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Professor Eduardo Eyras, Principal investigator
Major questions about the molecular mechanisms of rapid stress adaptation remain unanswered.
Student intake
Open for Bachelor, Honours, Masters students
Status
Current
People
- Dr Nikolay Shirokikh, Principal investigator
This project aims to investigate the role of APA in cell fate by studying CD8+ T cells that respond to virus infections and how RNA-binding proteins (RBPs) regulate APA in T cell differentiation.
Theme
- Cancer
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Associate Professor Jean (Jiayu) Wen, Principal investigator
- Professor David Tscharke, Researcher
- Professor Ian Cockburn, Researcher
A multitude of brain cancer (glioma) mutations, identified by large-scale next generation sequencing (NGS), are predicted to drive disease through computational algorithms in silico.
Student intake
Open for Honours, PhD students
Status
Current
People
- Professor Leonie Quinn, Supervisor
This study investigates how UBF isoforms remodel ribosomal DNA (rDNA) chromatin, aiming to elucidate their impact on chromatin dynamics and gene regulation.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Rita Ferreira, Supervisor
- Professor Ross Hannan, Supervisor
This study assesses the potential of second-generation RNA Polymerase I inhibitors as therapeutic agents for cancer by evaluating their ability to inhibit cancer cell growth and proliferation.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nadine Hein, Supervisor
- Dr Rita Ferreira, Supervisor
- Professor Ross Hannan, Supervisor
This project aims to shed light on the role of APA and its regulation by RNA-binding proteins (RBPs) in the retina, with a particular focus on responses to oxidative stress as observed in AMD.
Theme
- Cancer
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Associate Professor Jean (Jiayu) Wen, Principal investigator
- Associate Professor Riccardo Natoli, Researcher
To determine the role of histone variants, and other important epigenetic regulators, in regulating gene transcription and splicing.
Student intake
Open for Honours, PhD students
Status
Potential
People
- Professor David Tremethick, Supervisor
To elucidate the role of the epigenome, including the histone variant H2A.Z, in regulating the 3-dimensional architecture of the genome by inhibiting the expression of epigenetic regulators cellular differentiation.
Student intake
Open for Honours, PhD students
Status
Potential
People
- Professor David Tremethick, Supervisor
To study the role of histone variants and other epigenetic regulators in controlling pre-mRNA splicing on brain function and spermatogenesis using mouse knockout models. In addition, how the regulation of splicing impacts the progression of cancer using human breast cell lines.
Student intake
Open for Honours, PhD students
Status
Potential
People
- Professor David Tremethick, Supervisor
This project combines NGS technology with isolation of polyribosomal complexes from living cells, to generate transcriptome-wide snapshots of the distribution of translation complexes along mRNAs
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nikolay Shirokikh, Supervisor
We wish to identify malignant-specific rapid responses to drug stress and find new compounds that would block such responses and reduce the adaptation rate.
Student intake
Open for Bachelor, Honours, Masters, PhD students
Status
Current
People
- Dr Nikolay Shirokikh, Principal investigator
study how new therapeutics that treat malignancy impact on platelet function and contribute to dysregulation of thrombopoiesis and haemostasis.
The Whole Cell Model Development project, spearheaded by our ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems (MACSYS), is dedicated to constructing mathematical and machine learning models of entire cells, known as Whole Cell Models (WCM).
Theme
- Cancer
Student intake
Open for MPhil, PhD students
Status
Current
People
- Associate Professor Jean (Jiayu) Wen, Principal investigator