The Whole Cell Model Development project, spearheaded by our ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems (MACSYS), is dedicated to constructing mathematical and machine learning models of entire cells, known as Whole Cell Models (WCM). These models are poised to enhance traditional biological studies conducted in vivo and in vitro substantially. Through the innovation of new mathematics and computational technologies, MACSYS is on course to elevate biology to a predictive science and revolutionize our understanding of biological systems. We are committed to developing novel mathematical methods to decipher cellular functions and creating a computational system capable of translating genetic sequences into comprehensive whole cell models for any organism or cell type. Our goal is to construct, substantiate, and apply these models to specific microbes and cell types, thereby unveiling new biological insights. Moreover, these models will serve as investigative tools for fundamental questions regarding the manipulation and design of cells, the prediction of evolutionary trends, and the genesis of multi-cellular life and tissue development.

We are actively seeking passionate PhD students and Postdoctoral researchers to contribute to these cutting-edge research areas. Joining MACSYS offers a unique opportunity to be at the forefront of biotechnology and to collaborate within a world-class research and translation environment dedicated to solving some of the most fundamental questions in biology.

This project is funded by the Australian Research Council (ARC) Centres of Excellence Scheme