Projects
This project focuses on how germ cells control the function of Sertoli cells.
The broader goals of the project include facilitating the exploration of the RNA interactome for researchers and suggesting potential therapeutic interventions for diseases where RNA dysfunction is a significant factor, such as in cancers and genetic disorders.
Theme
- Cancer
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Associate Professor Jean (Jiayu) Wen, Principal investigator
This study aims to identify and understand mechanisms of intrinsic and acquired resistance to RNA Polymerase I (Pol I) inhibition in cancer, with the goal of developing strategies to overcome resistance to Pol I inhibitors.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nadine Hein, Supervisor
- Professor Ross Hannan, Supervisor
This study explores how dynamic changes in ribosomal DNA (rDNA) chromatin contribute to cancer development, aiming to uncover mechanisms of malignant transformation and potential therapeutic targets.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nadine Hein, Supervisor
- Professor Ross Hannan, Supervisor
This project focuses on the role of H2A.B in spermatogenesis under heat stress.
We aim to develop bioreactor technologies to grow Micro-Avatars of Tissue (MATs) by leveraging lessons from epithelial biology and cadherin-driven cell junctions.
Student intake
Open for Honours, PhD students
Status
Current
People
- Dr Woei Ming (Steve) Lee, Principal investigator
Our goal is to harness extensive single-cell and spatial transcriptome datasets to decipher APA/AS patterns and gene expression simultaneously, expanding the scope beyond conventional single-cell expression analysis.
Theme
- Cancer
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Associate Professor Jean (Jiayu) Wen, Principal investigator
This study aims to develop effective combination therapies using RNA Polymerase I (Pol I) inhibitors to enhance therapeutic efficacy and combat resistance in cancer treatment through synergistic effects with other drugs or treatments.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Associate Professor Amee George, Supervisor
- Dr Rita Ferreira, Supervisor
- Professor Ross Hannan, Supervisor
This project advances the development of innovative machine learning models designed to unearth conserved cis-regulatory RNA structures across vertebrate genomes. This initiative includes the creation of new RNA structure 2D/3D modeling and comparative genomics methods, underpinned by robust neural network architectures.
Theme
- Cancer
This project focuses on understanding the role of WNT in congenital heart defects.
Student intake
Open for Honours, PhD students
Status
Potential
People
- Professor Ruth Arkell, Supervisor
This study evaluates UBF (Upstream Binding Factor) as a potential target for cancer therapy by investigating its role in cancer cell growth and survival.
Theme
- Cancer
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Rita Ferreira, Supervisor
- Professor Ross Hannan, Supervisor
A number of our research projects seek to understand how ribosomal biogenesis controls thrombopoiesis.
Student intake
Open for Honours, Masters, PhD students
Status
Current
People
- Professor Elizabeth Gardiner, Supervisor
This project uses next generation sequencing (NGS) and mass spectrometry to investigate the possible existence of regulatory interactions between ribonucleic acids, enzymes and metabolites to connect gene expression and metabolism
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nikolay Shirokikh, Supervisor
- Professor Thomas Preiss, Supervisor
We've identified genetic factors contributing to kidney disease in the Australian Indigenous population and are creating mouse models and cell lines to study these genes and test potential treatments.
Theme
- Chronic disease
- Indigenous health
- Phenogenomics
This project focuses the role of H2A.B in Hodgkin Lymphoma.
This study identifies new cancer therapeutic targets within the RNA Polymerase I-specific transcription factor network to uncover potential innovative treatments.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Rita Ferreira, Supervisor
- Professor Ross Hannan, Supervisor
This study identifies ribosomal DNA sequence variations and analyzes their functional consequences.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nadine Hein, Supervisor
- Professor Eduardo Eyras, Supervisor
- Professor Ross Hannan, Supervisor
This study seeks to identify biomarkers predicting sensitivity to RNA Polymerase I (Pol I) inhibition to enhance patient stratification and treatment outcomes in cancer therapy.
Theme
- Phenogenomics
Student intake
Open for Honours, Masters, PhD students
Status
Potential
People
- Dr Nadine Hein, Supervisor
- Professor Ross Hannan, Supervisor
We wish to address gaps in capability by using accurate read-outs of translation efficiency available to us and developing methods for parallel extraction of structural, isoform and RNA-binding protein positional data, together with ligand-specific ribosome localisation read-outs.
Student intake
Open for Bachelor, Honours, Masters, PhD students
Status
Current
People
- Dr Nikolay Shirokikh, Principal investigator
This project focuses on Cancer/Testis (C/T) antigens and their function.