Our research focuses on inhibiting nucleic acid sensing receptors or signaling pathway molecules to prevent autoantibody production and autoimmune pathology in autoimmune mouse models, in collaboration with the Gantier Group at the Hudson Institute of Medical Research.

We investigate cytokine roles in SLE and opportunities for projects studying their impact on autoreactive B cell survival, focusing on identified genetic variants and therapeutic targets.

Our project investigates a novel DNA sensor's role in preventing cell proliferation and colorectal cancer by modulating immune responses and inflammation.

Our project investigates novel NLRP3 inhibitors to understand their efficacy in human cells and preclinical models of chronic inflammatory diseases.

We've discovered that platelets help remove aged red blood cells by forming complexes that target them for destruction in the spleen, a process crucial for preventing thrombosis and maintaining red blood cell homeostasis.

We utilise a unique mouse model to explore the interaction between genetic predisposition and environmental factors in promoting autoimmune disease development, particularly in SLE research.