Dr Nadine Hein

Contacts

Contact email:nadine.hein@anu.edu.au
Contact phone:+61 2 612 53086
Location:Room 3.343
Centre:Division of Genome Sciences and Cancer
Centre:In Vivo Imaging and Therapy Platforms Facility
Link:ANU Researchers profile
PhD
Fellow
  • Panov, K, Hannan, K, Hannan, R et al. 2021, 'The ribosomal gene loci—the power behind the throne', GENES, vol. 12, no. 5, p. 17.
  • Amarasiri, M, VO, Y, Gardiner, M et al. 2021, 'The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461', Australian Journal of Chemistry, vol. 74, no. 7, pp. 540-556.
  • Son, J, Hannan, K, Poortinga, G et al. 2020, 'rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461', Frontiers in Cell and Developmental Biology, vol. 8, pp. 1-14.
  • Khot, A, Brajanovski, N, Cameron, D et al 2019, 'First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study', Cancer Discovery, vol. 9, no. 8, pp. 1036-1049.
  • Diesch, J, Bywater, M, Sanij, E et al 2019, 'Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation', Communications Biology, vol. 2, no. 39, pp. 1-14pp.
  • MacLachlan, K, Cuddihy, A, Hein, N et al 2018, 'Novel combination therapy targeting rDNA transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM', <>, p. 1945.
  • Nunez Villacis, L, Wong, M, Ferguson, L et al. 2018, 'New Roles for the Nucleolus in Health and Disease', Bioessays, vol. 40, no. 5, pp. 11pp.
  • He, J, Soo, H, Evers, M et al. 2018, 'High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology', Assay and Drug Development Technologies, vol. 16, no. 6, pp. 320-332pp.
  • Nunez Villacis, L, Al-Obaidi, S, Madhamshettiwar, P et al. 2018, 'A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia', Blood, vol. 132, no. 1.
  • El-Ayoubi, A, Wang, J, Hein, N et al 2017, 'Role of plasma cells in Waldenström macroglobulinaemia', Pathology, vol. 49, no. 4, pp. 337-345pp.
  • Hein, N, Cameron, D, Hannan, K et al. 2017, 'Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population', Blood, vol. 129, no. 21, pp. 2882-2895pp.
  • Diwakarla, C, Hannan, K, Hein, N et al. 2017, 'Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options', World Journal of Gastroenterology, vol. 23, no. 13, pp. 2276-2285pp.
  • Hein, N, Hannan, K, D'Rozario, J et al. 2017, 'Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer', Technology in Cancer Research and Treatment, vol. 16, no. 6, pp. 736-739pp.
  • Talaulikar, D, Lim, J, Wang, J et al 2017, 'Plasma cells arise from differentiation of clonal lymphocytes and secrete IGM in Waldenstrom Macroglobulinemia', 22nd Congress of the European Hematology Association, ed. Jan Cools (Leuven), Ferrata Storti Foundation, Italy, pp. Volume: 102, Supplement 2, pages 569-570.
  • Devlin, J, Hannan, K, Hein, N et al. 2016, 'Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma', Cancer Discovery, vol. 6, no. 1, pp. 59-70.
  • Quin, J, Chan, K, Devlin, J et al. 2016, 'Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling', Oncotarget, vol. 7, no. 31, pp. 49800-49818.
  • Sanji, E, Diesch, J, Lesmana, A et al 2015, 'A novel role for the pol I transcription factor ubtf in maintaining genome stability through the regulation of highly transcribed pol II genes', Genome Research, vol. 25, no. 2, pp. 201-212.
  • Hein, N, Hannan, K, George, A et al. 2013, 'The nucleolus: An emerging target for cancer therapy', Trends in Molecular Medicine, vol. 19, no. 11, pp. 643-654.
  • Bywater, M, Hannan, R, Poortinga, G et al 2012, 'Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53', Cancer Cell, vol. 22, no. 1, pp. 51-65.
  • Hein, N, Jiang, K, Cornelissen, C et al 2011, 'TGF beta 1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors', BMC Molecular Biology, vol. 12, no. 9, pp. 1471-2199.
  • Hannan, K, Sanij, E, Hein, N et al. 2011, 'Signaling to the Ribosome in Cancer-It Is More Than Just mTORC1', IUBMB Life, vol. 63, no. 2, pp. 79-85.
  • Hydbring, P, Bahram, F, Su, Y et al 2010, 'Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 1, pp. 58-63.