2014-2018: Australian Research Council discovery grant (DP150102883): To investigate the roles of a novel family of transporters in Apicomplexan biology ($560,000)
2014-2015: Perpetual Foundation (FR2014/1152): Testing of a novel attenuated parasite vaccine ($200,000)
2014: Ian Potter Foundation (32616): To support the purchase of a multiphoton microscope for intravital imaging studies ($50,000)
Cockburn IA and Zavala F (2016) Dendritic cell function and antigen presentation in malaria. Curr Opin Immunol. 40:1-6.
*Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP and Cockburn IA (2015) Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. PLoS Pathog. 6;11(2):e1004637.
Bijker EM, Nganou-Makamdop K, van Gemert GJ, Zavala F, Cockburn I and Sauerwein RW (2015) Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria. Malar J. 26;14:130.
Dups JN, Pepper M and Cockburn IA. (2014) Antibody and B cell responses to Plasmodium sporozoites.Front Microbiol. 18;5:625.
Kelemen RK, He GF, Woo HL, Lane T, Rempe C, Wang J, Cockburn IA, Amino R, Ganusov VV, and Berry MW (2014) Classification of T cell movement tracks allows for prediction of cell function. Int J Comput Biol Drug Des. 7(2-3):113-29.
Tse SW, Radtke AJ, Espinosa DA, Cockburn IA and Zavala F (2014) The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8⁺ T cells specific for infectious pathogens. J Infect Dis. 210(9):1508-16.
*Cockburn IA, Tse SW and Zavala F (2014) CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect. Infect Immun. 82(4):1460-4.
Ménard R, Tavares J, Cockburn I, Markus M, Zavala F, and Amino R (2013) Looking under the skin: the first steps in malarial infection and immunity. Nat Rev Microbiol. 11(10):701-12.
*Cockburn IA, Amino R, Kelemen RK, Kuo SC, Tse SW, Radtke A, Mac-Daniel L, Ganusov VV, Zavala F and Ménard R (2013) In vivo imaging of CD8+ T cell-mdeiated elimination of malaria liver stages. Proc Natl Acad Sci USA; 110 (22): 9090-9095
Tse SW, Cockburn IA, Zhang H, Scott AL and Zavala F (2013) Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites Genes Immun; doi: 10.1038/gene.2013.20
Cockburn IA (2012) Chimeric parasites as tools to study Plasmodium immunology and assess malaria vaccines in “Malaria: Methods and Protocols, 2nd Edition” ed. Robert Menard
*Cockburn IA, Tse SW, Srinivasan P, Radtke A, Chen YC, Sinnis P and Zavala F (2011) Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo. PLoS Pathog; 7 (3): e1001318
Overstreet MG, Chen YC, Cockburn IA, Tse SW and Zavala F (2011) CD4 T cells modulate expansion and survival but not functional properties of effector and memory CD8 T cells induced by malaria sporozoites. PLoS One; 6 (1): e15948
*Cockburn IA, Chen YC, Overstreet MG, Lees JR, van Rooijen N, Farber DL and Zavala F (2010) Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog; 6 (5): e1000877
Overstreet MG, Freyberger H, Cockburn IA, Chen YC, Tse S and Zavala F (2010) CpG-enhanced CD8+ T cell responses to peptide immunization are severely inhibited by B cells. Eur J Immunol; 40 (1): 124-133
Joshi T, Rodriguez S, Perovic V, Cockburn IA and Stäger S (2009) B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. PLoS Pathog; 5(5): e1000431
Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska A, Fox-Talbot K, Sullivan D, Lowenstein CJ, Zavala F and Morrell CN (2008) Platelet Factor 4 mediates inflammation in cerebral malaria. Cell Host Microbe; 4 (2): 179-87
Overstreet MG, Cockburn IA, Chen YC and Zavala F (2008) Protective CD8+ T cells against malaria liver stages: immunobiology of an unnatural immune response. Immunol Rev; 225: 272-83
*Cockburn IA, Chakravarty S, Overstreet MG, Garcia Sastre A and Zavala F (2008) Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation. J Immunol; 180 (1): 64-71
*Chakravarty S, Cockburn IA, Kuk S, Overstreet MG, Sacci J and Zavala F (2007) Protective CD8+ T lymphocytes against malaria liver stages are primed in skin-draining lymph nodes. Nat Med; 13 (9): 1035-41
Cockburn IA and Zavala F (2007) T cell memory in malaria. Curr Op Immunol; 19 (4): 424-9
*Kaestli M, Cockburn IA, Cortes A, Baea K, Rowe JA and Beck HP (2006) Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study. J Infect Dis; 193(11):1567-74
Morrot A, Cockburn IA, Overstreet M, Rodriguez D and Zavala F (2006) Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression. Infect Immun; 74(4):2495-7
Hafalla JC, Cockburn IA and Zavala F (2006) Protective and pathogenic roles of CD8+ T cells during malaria infection. Parasite Immunol; 28(1-2):15-24
Cockburn IA and Rowe JA (2006) Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene. Int J Immunogenet; 33(1):17-20
Morrot A, Hafalla JC, Cockburn IA, Carvalho LH and Zavala F (2005) IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med; 202(4):551-60
*Cockburn IA, Mackinnon MJ, O'Donnell A, Allen SJ, Moulds JM, Baisor M, Bockarie M, Reeder JC and Rowe JA (2004) A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci U S A; 101(1):272-7
Cockburn IA, Donvito B, Cohen JH and Rowe JA (2002) A simple method for accurate quantification of complement receptor 1 on erythrocytes preserved by fixing or freezing. J Immunol Methods; 271(1-2):59-64.