Associate Professor Ian Cockburn

Group Leader

2014-2018: Australian Research Council discovery grant (DP150102883): To investigate the roles of a novel family of transporters in Apicomplexan biology ($560,000)

2014-2015: Perpetual Foundation (FR2014/1152): Testing of a novel attenuated parasite vaccine ($200,000)

2014: Ian Potter Foundation (32616):  To support the purchase of a multiphoton microscope for intravital imaging studies ($50,000)

Research interests

My group looks at different aspects of the immune response to the malaria parasite Plasmodium. We study not only how CD8+ T cells and antibodies can provide protection, but also how in some cases immune responses can cause pathogenic responses such as cerebral malaria. Your project in the lab would be to use knockout and mutant mice to unravel how these pathogenic responses develop in malaria and, in the longer run, to understand how such responses can be prevented with drugs and therapeutic vaccines.

Cockburn IA and Zavala F (2016) Dendritic cell function and antigen presentation in malaria. Curr Opin Immunol. 40:1-6.

*Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP and Cockburn IA (2015) Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. PLoS Pathog. 6;11(2):e1004637.

Bijker EM, Nganou-Makamdop K, van Gemert GJ, Zavala F, Cockburn I and Sauerwein RW (2015) Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria. Malar J. 26;14:130.

Dups JN, Pepper M and Cockburn IA. (2014) Antibody and B cell responses to Plasmodium sporozoites.Front Microbiol. 18;5:625.

Kelemen RK, He GF, Woo HL, Lane T, Rempe C, Wang J, Cockburn IA, Amino R, Ganusov VV, and Berry MW (2014) Classification of T cell movement tracks allows for prediction of cell function. Int J Comput Biol Drug Des. 7(2-3):113-29.

Tse SW, Radtke AJ, Espinosa DA, Cockburn IA and Zavala F (2014) The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8 T cells specific for infectious pathogens. J Infect Dis. 210(9):1508-16.

*Cockburn IA, Tse SW and Zavala F (2014) CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect. Infect Immun. 82(4):1460-4.

Ménard R, Tavares J, Cockburn I, Markus M, Zavala F, and Amino R (2013) Looking under the skin: the first steps in malarial infection and immunity. Nat Rev Microbiol. 11(10):701-12.

*Cockburn IA, Amino R, Kelemen RK, Kuo SC, Tse SW, Radtke A, Mac-Daniel L, Ganusov VV, Zavala F and Ménard R (2013) In vivo imaging of CD8+ T cell-mdeiated elimination of malaria liver stages. Proc Natl Acad Sci USA; 110 (22): 9090-9095

Tse SW, Cockburn IA, Zhang H, Scott AL and Zavala F (2013) Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites Genes Immun; doi: 10.1038/gene.2013.20

Cockburn IA (2012) Chimeric parasites as tools to study Plasmodium immunology and assess malaria vaccines in “Malaria: Methods and Protocols, 2nd Edition” ed. Robert Menard

*Cockburn IA, Tse SW, Srinivasan P, Radtke A, Chen YC, Sinnis P and Zavala F (2011) Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo. PLoS Pathog; 7 (3): e1001318

Overstreet MG, Chen YC, Cockburn IA, Tse SW and Zavala F (2011) CD4 T cells modulate expansion and survival but not functional properties of effector and memory CD8 T cells induced by malaria sporozoites. PLoS One; 6 (1): e15948

*Cockburn IA, Chen YC, Overstreet MG, Lees JR, van Rooijen N, Farber DL and Zavala F (2010) Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog; 6 (5): e1000877

Overstreet MG, Freyberger H, Cockburn IA, Chen YC, Tse S and Zavala F (2010) CpG-enhanced CD8+ T cell responses to peptide immunization are severely inhibited by B cells. Eur J Immunol; 40 (1): 124-133

Joshi T, Rodriguez S, Perovic V, Cockburn IA and Stäger S (2009) B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. PLoS Pathog; 5(5): e1000431

Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska A, Fox-Talbot K, Sullivan D, Lowenstein CJ, Zavala F and Morrell CN (2008) Platelet Factor 4 mediates inflammation in cerebral malaria. Cell Host Microbe; 4 (2): 179-87

Overstreet MG, Cockburn IA, Chen YC and Zavala F (2008) Protective CD8+ T cells against malaria liver stages: immunobiology of an unnatural immune response. Immunol Rev; 225: 272-83

*Cockburn IA, Chakravarty S, Overstreet MG, Garcia Sastre A and Zavala F (2008) Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation. J Immunol; 180 (1): 64-71

*Chakravarty S, Cockburn IA, Kuk S, Overstreet MG, Sacci J and Zavala F (2007) Protective CD8+ T lymphocytes against malaria liver stages are primed in skin-draining lymph nodes. Nat Med; 13 (9): 1035-41

Cockburn IA and Zavala F (2007) T cell memory in malaria. Curr Op Immunol; 19 (4): 424-9

*Kaestli M, Cockburn IA, Cortes A, Baea K, Rowe JA and Beck HP (2006) Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study. J Infect Dis; 193(11):1567-74

Morrot A, Cockburn IA, Overstreet M, Rodriguez D and Zavala F (2006) Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression. Infect Immun; 74(4):2495-7

Hafalla JC, Cockburn IA and Zavala F  (2006) Protective and pathogenic roles of CD8+ T cells during malaria infection. Parasite Immunol; 28(1-2):15-24

Cockburn IA and Rowe JA (2006) Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene. Int J Immunogenet; 33(1):17-20

Morrot A, Hafalla JC, Cockburn IA, Carvalho LH and Zavala F (2005) IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med; 202(4):551-60

*Cockburn IA, Mackinnon MJ, O'Donnell A, Allen SJ, Moulds JM, Baisor M, Bockarie M, Reeder JC and Rowe JA (2004) A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci U S A; 101(1):272-7

Cockburn IA, Donvito B, Cohen JH and Rowe JA  (2002) A simple method for accurate quantification of complement receptor 1 on erythrocytes preserved by fixing or freezing. J Immunol Methods; 271(1-2):59-64.