Division of Genome Sciences and Cancer

Phenomics & Genomics

We offer a range of services in next-generation sequencing technology and bioinformatics opening up a new dimension for integrating phenomics, molecular biology, and systems biology for mouse and human.

About

Next-generation sequencing technology and bioinformatics have opened up a new dimension for integrating phenomics, molecular biology, and systems biology for mouse and human. Our highly validated pipeline will accurately identify your variants using the following services.

Services

3D Bioprinting

3D bioprinting and droplet-based robotics create simple or complex, tissue-like structures that generate mammalian organoids for drug discovery and disease modeling in high-throughput.

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ACTD Consumable Store

The ACTD onsells automation consumables such as tips, microplates (96, 384, 1536), tissue culture consumables, screening reagents, transfection reagents and more.

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Assay Development (Service)

Through close collaboration, we adopt assays established in your laboratory and make them amenable for boutique and large scale high-throughput screening.

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ACTD Robots

Our automation and liquid handling services streamline laboratory workflows by increasing precision, reproducibility and enhancing efficiency in high-throughput processes.

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The APF team specializes in helping you to translate large, unwieldy sequencing datasets into manageable information in days, not months.

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Compound Screening

High-throughput compound screening evaluates large libraries of chemical compounds to discover candidates for the development of new treatments and therapies.

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CRISPR Screening Service

CRISPR screening systematically modifies genes across a genome, enabling researchers to identify genes that are crucial for specific cellular functions or disease processes.

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The Australian Phenome Bank handles all ordering requests. Please visit the Australian Phenome Bank website for further information.

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The Australian Phenomics Facility experienced team of genomic and bioinformatic specialists offer exome and whole genome service packages built around researcher “end-to-end” requirements and provide a number of tools not otherwise available in a standard sequencing service.

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Genotyping

This site is under construction.

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High Content Imaging & Analysis

High-content imaging is an advanced technique that combines automated microscopy with image analysis to capture and quantify complex cellular phenotypes at high resolution.

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High-Throughput Flow Cytometry

High-throughput flow cytometry enables the rapid, multiparametric analysis of thousands of cells for large-scale screening and detailed cellular characterization in drug discovery and immunology.

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Illumina

BRF Illumina NGS technologies support a wide range of genomic applications, such as whole genome & exome sequencing, RNA-seq, epigenetics, metagenomics, HiC and more.

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In vitro fertilisation (IVF) is used to re-animate strains from the frozen state from sources such as the repository of the Australian Phenome Bank. The team is using the latest and most efficient IVF techniques and re-animation success is currently running at 97% of attempts with sperm thawed from the APB archive.

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We provide space, equipment and expertise to run small or large projects to map the chromosomal location and identify the affected gene of new gene-variant mouse strains obtained from N-ethyl-N-nitrosourea (ENU) libraries, spontaneous mutations or causative polymorphisms.

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Nanopore

A certified Oxford Nanopore sequencing facility, delivering sample QC, library preparation and long-read seequencing solutions to the ANU, to Australia, and to overseas projects with MinION and PromethION technology.

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Organoid, Spheroid & 3D Screening

Organoids and spheroids mimic the architecture and function of tissues, making them valuable tools in high-throughput 3D screening for drug discovery and disease modeling.

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PacBio

The PacBio Revio, a cutting-edge DNA sequencer, accelerates research and drives innovation across various sectors.

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We provide space, equipment and expertise to run small or large projects to map the chromosomal location and identify the affected gene of new gene-variant mouse strains obtained from N-ethyl-N-nitrosourea (ENU) libraries, spontaneous mutations or causative polymorphisms.

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Depending on their housing and transportation conditions mouse strains may be carrying a multitude of pathogens that may or may not result in disease but may very well affect your experimental result outcomes.

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RNAi Screening

RNA interference (RNAi) screening is a technique used to knock down specific genes to study their function and identify potential therapeutic targets.

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Sanger image

We are committed to provide an excellent service, accurate results, fast turnaround times, at low cost.

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We validate any SNVs identified through exome, whole genome or targeted sequencing.

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