• Altin JA, Daley SR, Howitt J, Rickards HJ, Batkin AK, Horikawa K, Prasad SJ, Nelms KA, Kumar S, Wu LC, Tan SS, Cook MC, Goodnow CC. Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2067-74. PMID: 24520172

    Bull KR, Mason T, Rimmer AJ, Crockford TL, Silver KL, Bouriez-Jones T, Hough TA, Chaudhry S, Roberts IS, Goodnow CC, Cornall RJ. Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. J Pathol. 2014 May;233(1):18-26. PMID: 24293254

    Siggs OM, Yates AL, Schlenner S, Liston A, Lesage S, Goodnow CC. A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. Immunology. 2014 Apr;141(4):587-95. PMID: 24266404

    Wang JQ, Jeelall YS, Beutler B, Horikawa K, Goodnow CC. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med. 2014 Mar 10;211(3):413-26. PMID: 24534189

    Correspondence to Nature: Brown S, Moore M, Adams DJ, Hrabé de Angelis M, Wurst W, McKerlie C, Hérault Y, Bertram E, ObataY, Tocchini-Valentini G, Gao X, Braun B, Lloyd K, Seong JK, Beaudet A, Wang L, Flickek P, Sedlacek R, O’Neill R, Batty J, Schloss J, Green E. Mouse already being charted gene by gene. Nature 508 (7496), 319. 17 April 2014. PMID: 24740057

    Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC. Redemption of autoantibodies on anergic B  cells by variable-region glycosylation and mutation away from self-reactivity. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. PMID: 24821781

    Lee CE, Fulcher DA, Whittle B, Chand R, Fewings N, Field M, Andrews D, Goodnow CC, Cook MC. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. Blood. 2014 Nov 6;124(19):2964-72. PMID: 25237204

    Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. Elife. 2014 Oct 24;3. PMID: 25343476

    Enders A, Short A, Miosge LA, Bergmann H, Sontani Y, Bertram EM, Whittle B, Balakishnan B, Yoshida K, Sjollema G, Field MA, Andrews TD, Hagiwara H, Goodnow CC. Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4513-8. PMID: 24616512

    Cho V, Mei Y, Sanny A, Chan S, Enders A, Bertram EM, Tan A, Goodnow CC, Andrews TD. The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA. Genome Biol. 2014 Jan 29;15(1):R26. doi: 10.1186/gb-2014-15-1-r26. PMID: 24476532


  • Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP (2013)
    Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies.
    eLife 2013;2:e01020


  • Andrews TD, whittle B, Field MA, Balakishnan B, Zhang Y, Cho V, Kirk M, Singh M, Xia Y, Hager J, Winslade S, Sjollema G, Beutler B, Enders A, Goodnow CC (2012)
    Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousand of new mouse models
    Open Biol, 2(5):1 120061
  • Lo JC, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, Field MC, Adams V, Ishikawa T, Aitken RJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK (2012)
    RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly
    PLoS Genet 8(10):e1002969. doi: 10.1371/journal.pgen.1002969
  • Altin, JA, Goodnow CC, Cook MC (2012)
    Th2 Inhibitory Cells Form in a Foxp3-Independent, IL-2-Dependent Manner from Th2 Effectors during Chronic Inflammation
    Journal of Immunology 188(11): 5478-5488
  • Pheh-Ping Chang, Sau K. Lee, Xin Hu, Gayle Davey, Guowen Duan, Jae-Ho Cho, Guna Karupiah, Jonathan Sprent, William R Heath, Edward M Bertram, Carola G Vinuesa (2012)
    Breakdown in Repression of IFN-g mRNA Leads to Accumulation of Self-Reactive Effector CD8+ T Cells
    The Journal of Immunology 189(2): 701-710


  • Altin JA, Tian L, Liston A, Bertram EM, Goodnow CC, Cook MC (2011)
    Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3–positive regulatory versus TH2 effector cells to cause allergy
    J Allergy Clin Immunol 127(5):1277-1285 PMID: 21320717
  • Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Broer S, Goodnow CC, Enders A (2011)
    ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.
    Nat Immunol 12(5):441-9 PMID: 21423173
  • Tze LE, Horikawa K, Domaschenz H, Howard DR, Roots CM, Rigby RJ, Way DA, Ohmura-Hoshina M, Ishido S, Andoniuo CE, Degli-Esposti MA, Goodnow CC (2011)
    CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
    J Exp Med 208(1):149-65 PMID: 21220452


  • Papathanasiou P, Tunningley R, Pattabiraman DR, Ye P, Gonda TJ, Whittle B, Hamilton AE, Cridland SO, Lourie R, Perkins AC (2010)
    A recessive screen for genes regulating hematopoietic stem cells
    Blood 116(26):5849-5858 PMID: 20610815
  • Jamsai D, O’Bryan MK (2010)
    Genome-wide ENU mutagenesis for the discovery of novel male fertility regulators
    Syst Biol Reprod Med 56(3):246-59 PMID: 20536324


  • Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC (2009)
    Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
    Nat Immunol 10(12):1283-91 PMID: 19898472


  • Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, Weiss A, Liston A, Goodnow CC. (2007)
    Opposing Functions of the T cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions.
    Immunity 27(6):912-26 PMID: 18093540
  • Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG. (2007)
    Roquin Represses Autoimmunity by Limiting inducible T-cell co-stimulator messenger RNA.
    Nature 450(7167):299-303 PMID: 18172933
  • Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ. (2007)
    DNA repair is limiting for haematopoietic stem cells during ageing.
    Nature. 447(7145):686-90 PMID: 17554302
  • Gosling KM, Makaroff LE, Theodoratos A, Kim YH, Whittle B, Rui L, Wu H, Hong NA, Kennedy GC, Fritz JA, Yates AL, Goodnow CC, Fahrer AM. (2007)
    A mutation in a chromosome condensing condensin II subunit, kleisin beta, specifically disrupts T cell development.
    Proc Natl Acad Sci USA. 104(30):12445-50 PMID: 17640884
  • Miosge LA, Goodnow CC. (2005)
    Genes, pathways and checkpoints in lymphocyte development and homeostasis.
    Immunology and Cell Biology 83: 318-335 PMID: 16033527
  • Kennedy, CL, O.Connor, AE, Sanchez-Partida, LG, Holland, MK, Goodnow, CC, de Kretser, DM, O.Bryan MK. (2005)
    A repository of ENU mutant mouse lines and their potential for male fertility research.
    Mol Hum Reprod 11:871-880 PMID: 16421219
  • Papathanasiou P, Goodnow CC. (2005)
    Connecting mammalian genome with phenome by ENU mutagenesis: gene combinations specifying the immune system.
    Annual Review in Genetics 39:241-62 PMID: 16053407
  • Vinuesa C, Tangye S, Moser B and Mackay C. (2005)
    Follicular B helper T cells in antibody responses and autoimmunity
    Nature Rev Immunol. 5, 853-865 PMID: 16261173
  • Goodnow C, Sprent J, Fazekas de St Groth B and Vinuesa C. (2005)
    Cellular and genetic mechanisms of self tolerance and autoimmunity.
    Nature, 435, 7042. PMID: 15931211
  • Vinuesa, C.G., Cook, M.C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K.M., Y, Yu, D., Domaschenz, H., Whittle, B., Lambe, T., Roberts, I.S., Copley, I.R., Bell, J.I., Cornall, R.J., and Goodnow, C.C. (2005)
    A novel RING-type ubiquitin ligase family member essential to repress follicular helper T cells and autoimmunity.
    Nature 435: 452-458 PMID: 15917799
  • Vinuesa C and Goodnow C. (2004)
    Illuminating autoimmune regulators through controlled variation of the mouse genome sequence.
    Immunity, 20:669-79 PMID: 15189733
  • Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST and Goodnow CC. (2003)
    Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.
    Immunity 19; 131-144. PMID: 12871645
  • Jun, J.E. Wilson, L.E. Vinuesa, C.G. Lesage, S. Blery, M, Miosge, L.A. Cook, M.C. Kucharska, E.M. Dolmashenz, H, Hong, N.A. Glynne, R.J. Hara, H. Penninger, J.M. Nelms, K.A. Goodnow, C.C. (2003)
    Identifying the MAGUK-protein Carma-1 as a central regulator of humoral immune responses and atopy by genome wide mouse mutagenesis.
    Immunity 18| : 751-762 PMID: 12818157
  • Loy, A., Goodnow, C. (2002)
    Novel approaches for identifying genes regulating lymphocyte development and function.
    Current Opinion in Immunology, 14:260-5. PMID: 11869902
  • Miosge, L.M. Blasioli, J. Blery, M. Goodnow, C.C. (2002)
    Analysis of an ENU-generated mouse mutation defines a cell intrinsic role of NFkB2 in regulating circulating B cell numbers.
    J. Exp. Med 196:| 1113-1119. PMID: 12391023