Professor Simon Foote
I have a medical degree, a BMedSci and a PhD from the University of Melbourne and a DSc from the University of Tasmania. I did my postdoctoral training at the Whitehead Institute, MIT, Cambridge, USA in the early mapping of the human genome. I spent a decade at the Walter and Eliza Hall Institute and was co-head of the Genetics and Bioinformatics Division. In 2005 I became director of the Menzies Research Institute in Hobart. From 2012-2014 I was Dean of the Australian School of Medicine at Macquarie University and have been Director of The John Curtin School of Medical Research at ANU since 2014.
I am interested in the genetics of several diseases that affect isolated, less affluent populations. My group works on the host response to infection by malarial parasites. Primarily we use rodent parasites but also translate our findings into humans. I work closely with Associate Professor Brendan McMorran and Dr Gaetan Burgio. Together, we have implicated platelets as being an important component of the innate immune response against malaria. We are also interested in designing new drugs that target the host and are therefore less prone to the development of drug resistance by the parasite. We have identified a large number of potential drug targets.
We also work on the genetics underpinning the renal disease that is so common in Australian Aboriginal communities. We work closely with the Tiwi people of the Northern Territory.
Dogovski C, Xie SC, Burgio G et al. (2015) Targeting the cell response of Plasmodium falciparum to overcome Artemisinin resistance. PLoS Biology 13(4):e1002132
Blackburn N, Charlesworth J, Marthick J et al (2015) A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study. Oncology Reports 33(1):25-32
Smith C, Jerkovic A, Puy H et al (2015) Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites', Blood 125(3):534-41
Brizuela M, Huang, HM, Smith C, Burgio G, Foote, SJ and McMorran, BJ (2014) Treatment of erythrocytes with the 2Cys, peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. PLoS One 9(4):e92411
Lelliott P, Lampkin S, McMorran BJ, Foote, SJ and Burgio G (2014) A flow cytometric assay to quantify invasion of red blood cells by rodent Plasmodium parasite in vivo. Malaria Journal 13:100
McMorran BJ, Burgio G and Foote, SJ (2013) New insights into the protective power of platelets in malaria infection. Communicative and Integrative Biology 6(3):e23653
Greth A, Lampkin S, Mayura-Guru P, Rodda F, Drysdale K, Roberts-Thomson M, McMorran BJ, Foote SJ and Burgio G (2012) A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice. PLoS One 7(6):e38999
McMorran B, Wieczorski L, Drysdale K, Chan J, Huang HM, Smith C, Mitik, C, Beeson JG, Burgio G and Foote, S (2012) Platelet Factor-4 and Duffy-Antigen Required for Platelet Killing of Plasmodium falciparum. Science 338:1348-1351
Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S and Gros P (2011) Host resistance to malaria: Using mouse models to explore the host response. Mammalian Genome 22:32-42
McMorran B, Marshall V, de Graaf, C et al (2009) Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323(5915):797-800
Bahlo M, Booth D, Broadley S et al (2009) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics 41(7):824-828