Simon completed his medical degree from the University of Newcastle and specialist training in Nephrology at The Canberra and Royal Prince Alfred Hospitals. He received his Masters in Medicine(Hons) from the University of Sydney and his PhD as an NHMRC/RACP scholar investigating the role of genetic variation in systemic lupus erythematosus.
Simon investigates the genetics of systemic autoimmunity and kidney disease and is chief investigator for the Genetic Variation in Immune-Mediated Kidney Disease program, Canberra Hospital. His research focuses on the genetic and molecular basis of autoimmunity and kidney disease, and the mechanisms contributing to organ-specific disease. He also investigates the genetic contribution to kidney disease in the Tiwi Islands as part of the ANU Grand Challenge in Indigenous Health and Wellbeing. As a nephrologist and founding chair of the Translational Glomerulonephritis Clinic at The Canberra Hospital he works in incorporating genetic and molecular understanding of disease into precision medicine in autoimmune kidney disease.