The Fischer lab investigates the connection between chromatin structure, pervasive transcription and RNA surveillance, and their influence on genomic stability.
The Genomic Plasticity Lab studies how dynamic DNA structures and non-classical DNA modifications contribute to the formation and persistence of long-term memories, particularly in fear-related learning and memory.
The main focus of our research group is to study red blood cells and platelets, exploring their roles in diseases, with projects available for students interested in immunology, parasitology, and human genetics.
This study aims to identify and understand mechanisms of intrinsic and acquired resistance to RNA Polymerase I (Pol I) inhibition in cancer, with the goal of developing strategies to overcome resistance to Pol I inhibitors.
This study explores how dynamic changes in ribosomal DNA (rDNA) chromatin contribute to cancer development, aiming to uncover mechanisms of malignant transformation and potential therapeutic targets.
This study aims to develop effective combination therapies using RNA Polymerase I (Pol I) inhibitors to enhance therapeutic efficacy and combat resistance in cancer treatment through synergistic effects with other drugs or treatments.
We've identified genetic factors contributing to kidney disease in the Australian Indigenous population and are creating mouse models and cell lines to study these genes and test potential treatments.
This study identifies new cancer therapeutic targets within the RNA Polymerase I-specific transcription factor network to uncover potential innovative treatments.
Director, Canberra Clinical Phenomics Service Associate Professor, ANU School of Medicine and Psychology Staff Specialist in Immunology, Canberra Health Services
In a groundbreaking study, Dr Zaka Yuen and collaborators at the John Curtin School of Medical Research (JCSMR) utilised nanopore adaptive sampling to identify DNA methylation markers related to age and body fluids.
Scientists at The Shine-Dalgarno Centre for RNA Innovation (SDCRI) are teaming up with the community to unlock the full potential of ribonucleic acid (RNA). It could lead to breakthroughs in everything from cancer treatments and new therapies for complex diseases, to age-related macular degeneration and crop resilience.
Creating a historic moment for the John Curtin School of Medical Research (JCSMR), two of our outstanding PhD students Sasanan and Rakshanya claimed the winner and runner-up awards at the Australian National University (ANU) 3-Minute Thesis Competition 2024 grand finale, held on 25 July at Llewellyn Hall.
In a world where healthcare can feel impersonal, ANU researchers are making medical diagnoses at a genetic level and tailoring treatments to individuals like never before.