COARCT
A multicentre, open-label randomised controlled trial comparing the addition of compression therapy to standard care, with standard care alone, in the management of acute leg cellulitis: Internal Pilot Phase
ANZCTR Registration number ACTRN12625001371482
Project Status
Current; Recruiting
Indication
Cellulitis
Goal
Cellulitis is a common bacterial infection of the skin and underlying tissue. Acutely, it causes pain and swelling that significantly hinder daily activities. Longer-term, persistent oedema predisposes patients to recurrent cellulitis, creating a relentless cycle of swelling and infection. Our trial will evaluate whether adding compression therapy to standard antibiotic care at the onset of acute cellulitis can hasten resolution, avoid complications, minimise antibiotic use, and prevent recurrence. An initial internal pilot will refine procedures and support trial expansion. Our vision is to transform cellulitis management by targeting infection and oedema together, enabling faster recovery, reducing long-term disability, saving healthcare resources, and promoting antibiotic stewardship.
Method
Compression therapy will be provided to participants by a trial clinicians (nurses, physiotherapists, occupational therapists or physicians) in addition to standard care (antibiotics with or without analgesia, per local treatment guidelines). Participants will be measured for and prescribed two below knee compression class 1 (15-21 mmHg) compression garments. They will be encouraged to wear one garment on the affected leg immediately following randomisation, or as soon as possible/tolerable, and to continue wearing the stockings for one month, rotating the two garments every 1-2 days to allow for washing.
At Day 0 participants will be randomised in a 1:1 ratio to:
• Standard care, being antibiotic prescription as per the local protocol (control) or
• Standard care plus compression therapy (intervention)
From randomisation to Day 14 participants will be encouraged to wear the stocking 23hrs per day, with a short break for showering and performing skin care.
From Day 14 to 28 participants will be recommended to wear their stocking for at least 8 hours per day.
Contact
Dr Elizabeth Webb
elizabeth.webb@anu.edu.au
Griselda Buckland