This project focuses on novel morphometric analysis methods for emerging types of 3D image data.

While there is no perfect model to simulate all the pathologies associated with human AMD, we use a growing number of approaches to better understand the progression of AMD and retinal degenerations in general. These models also serve to test the efficacy of novel AMD therapeutic and diagnostic pipelines.

Exosomes are paramount to the pathogenesis of a plethora of neurodegenerative diseases but their role in retinal degenerations remains largely unknown. At the Clear Vision Research Lab we study exosomes using several miRNA-centered approaches.

The aim of this project is to understand the ways in which astrocytes can sense the activity at adjacent synapses and how in-turn they can release substances that modulate these synapses.

The aim of this project is to identify glutamate recycling mechanisms and to discover their role in maintaining the supply of glutamate for continued neurotransmission.

A tool for temporally controlled, cell-type, and compartment-specific RNA isolation in neurons.

Despite only being discovered as recently as the turn of this century, miRNAs are already used in clinical trials as therapeutic candidates for complex diseases. Our research aims to characterise key miRNAs in the retina and exploit those as therapeutic molecules in the retina.

We are exploring a number of therapeutic options, developed at ANU and by commercial partners, which include gene-based therapies, non-invasive therapeutics (including the use of low-level laser therapy using red light) and novel compounds.

This project will examine the function of the variety of amino acid transporters found in neuronal tissue.

We investigate the neuro-protective benefits of different forms of exercise to retinal health and aim to understand what molecular processes mediate this.Our ongoing projects aim to determine whether or not these benefits can be translated into therapeutic approaches for retinal diseases such as AMD.