Professor Elizabeth Gardiner

PhD
Director, The John Curtin School of Medical Research
Professor

Professor Elizabeth Gardiner is the 17th Director of the John Curtin School of Medical Research (JCSMR). She was also the Head of the Department of Cancer Biology and Therapeutics in JCSMR. She is Scientific Head of the National Platelet Referral and Research Centre at ANU and the Canberra Hospital. She has published 143 peer-reviewed research papers, commentaries and reviews in the area of platelet biochemistry and platelet function, particularly relevant to both thrombosis and bleeding in patients. She identified a novel mechanism for shedding of vascular receptors triggered by shear stress, enabling new capabilities in diagnostic and therapeutic reagent development.

She is a Trustee of the Thrombosis and Haemostasis society of Australia and New Zealand (THANZ), a Principal Editor and the Methods Editor of the journal Platelets, an Associate Editor of Arteriosclerosis, Thrombosis and Vascular Biology, and on the Editorial Board of Blood. She is Treasurer of the National Association of Research Fellows (NARF). She is Chair of the American Society of Hematology (ASH) Scientific Committee on Platelets and co-Chair of the International Society for Thrombosis and Haemostasis Biorheology Scientific Subcommittee. She has held executive roles in the Australian Vascular Biology Society.

  • Hicks, S, Coupland, L, Jahangiri, A et al 2020, 'Novel scientific approaches and future research directions in understanding ITP', Platelets, vol. 31, no. 3, pp. 315-321.
  • Montague PhD, S, Lim, Y, Lee, W et al. 2020, 'Imaging Platelet Processes and Function-Current and Emerging Approaches for Imaging in vitro and in vivo', Frontiers in Immunology, vol. 11, pp. -.
  • Jing, W, Yabas, M, Broer, A et al 2019, 'Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets', Blood Advances, vol. 3, no. 3, pp. 219-229pp.
  • Weller, C, Gardiner, E, Arthur, J et al 2019, 'Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms', International Wound Journal, vol. 16, no. 3, pp. 788-792.
  • Lui, M, Gardiner, E, Arthur, J et al. 2019, 'Novel Stenotic Microchannels to Study Thrombus Formation in Shear Gradients: Influence of Shear Forces and Human Platelet-Related Factors', International Journal of Molecular Sciences, vol. 20, no. 12, pp. -.
  • Gardiner, E & Andrews, R 2019, 'Platelet Ubiquitylation-It's Everywhere', Thrombosis and Haemostasis, vol. 119, no. 1, pp. 6-8.
  • Kaur, A, Kaur, A, Gardiner, E et al. 2019, 'Parkin the bus to manage stress', EMBO Molecular Medicine, vol. 11, no. 8.
  • Qiao J, Wines BD, Hogarth PM, Dunne E, Kenny D, McCarthy GM, Xu K, Andrews RK and Gardiner EE. Plasma levels of the soluble form of the Fc?RIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis. Platelets (2020) 31: 392-398.
  • Gardiner, E 2018, 'Proteolytic processing of platelet receptors', Research and Practice in Thrombosis and Haemostasis, vol. 2, no. 2, pp. 240-250.
  • Schroder, W, Le, T, Gardner, J et al 2018, 'SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation', Platelets, vol. 30, no. 5, pp. 658-663.
  • Qiao, J, Arthur, J, Gardiner, E et al 2018, 'Regulation of platelet activation and thrombus formation by reactive oxygen
    species', Redox Biology, vol. 14, pp. 126-130.
  • Flierl, U, Nero, T, Lim, B et al. 2018, 'Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment', Journal of Thrombosis and Haemostasis, vol. 16, no. 1, pp. 181-185.
  • Rivera, J & Gardiner, E 2018, 'An exit strategy for new platelets', Blood, vol. 131, no. 10, pp. 1041-1042.
  • Luu, S, Gardiner, E & Andrews, R 2018, 'Bone marrow defects and platelet function: A focus on MDS and CLL', Cancers, vol. 10, no. 147, pp. 1-10pp.
  • Qiao, J, Wu, X, Luo, Q et al. 2018, 'NLRP3 regulates platelet integrin aIIbβ3 outside-in signaling, hemostasis and arterial thrombosis', Haematologica, vol. 103, no. 9, pp. 1568-1576.
  • Andrews, R & Gardiner, E 2018, 'Monitoring the pulse of thrombus formation: Comment on 'Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones' by A.V. Belyaev et al.', Physics of Life Reviews, vol. 26-27, pp. 113-115pp.
  • Wines, B, Tan, C, Duncan, E et al 2018, 'Dimeric Fc-R ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia', Journal of Thrombosis and Haemostasis, vol. 16, no. 12, pp. 2520-2525pp.
  • He, X, Montague, SJ, Gardiner, E et al 2018, 'Quantifying Embolism: Label-Free Volumetric Mapping of Thrombus Structure and Kinesis in a Microfluidic System with Optical Holography', Advanced Biosystems, 1800089
  • Li, Y, Montague, SJ, Bruestle, A et al. 2018, 'High contrast imaging and flexible photomanipulation for quantitative in vivo multiphoton imaging with polygon scanning microscope', Journal of Biophotonics, 11 (7), e201700341
  • Montague, SJ & Gardiner, E 2018, 'Matrix metalloproteinase -13 unlucky for the forming thrombus.', Research and Practice in Thrombosis and Haemostasis, vol. 1, no. 4.
  • Montague, SJ, Andrews, RA & Gardiner, EE 2018, 'Mechanisms of receptor shedding in platelets', Blood, vol. 132, no. 24, pp. 2535-2545pp.
  • Casan, J, Andrews, R, Gardiner, E et al 2017, 'Mechanisms of Platelet Dysfunction in Patients with Implantable Devices', Seminars in Thrombosis and Hemostasis, vol. 44, no. 1, pp. 12-19.
  • Poulter, N, Pollitt, A, Owen, D et al 2017, 'Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets', Journal of Thrombosis and Haemostasis, vol. 15, no. 3, pp. 549-564pp.
  • Qiao, J, Wu, Y, Wu, X et al 2017, 'An absence of platelet activation following thalidomide treatment in vitro or in vivo', Oncotarget, vol. 8, no. 22, pp. 35776-35782.
  • Gardiner, E & Andrews, R 2017, 'Platelet Adhesion', in P. Gresele, Neal S. Kleiman, Jose A Lopez, Clive P Page (ed.), Platelets in Thrombotic and Non-Thrombotic Disorders, Springer International Publishing AG, Switzerland, pp. 309-319pp.
  • Andrews, R & Gardiner, E 2017, 'The cutting edge of platelets', Platelets, vol. 28, no. 4, pp. 317-318.
  • Andrews, R & Gardiner, E 2017, 'Basic mechanisms of platelet receptor shedding', Platelets, vol. 28, no. 4, pp. 319-324pp.
  • Rabbolini, D, Gardiner, E, Morel-Kopp, M et al 2017, 'Anti-glycoprotein VI mediated immune thrombocytopenia: An under-recognized and significant entity?', Research and Practice in Thrombosis and Haemostasis, vol. 1, no. 2, pp. 291-295.
  • Coupland, L, Hindmarsh, L, Gardiner, E et al 2017, 'The influence of platelet membranes on tumour cell behaviour', Cancer and Metastasis Reviews, vol. 36: 215-224
  • Montague, SJ, Lee, CSM, Lee, W et al. 2018, 'Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI', Blood Advances, vol. 2, no. 3, pp. 240-251pp.
  • Trevillyan, J, Gardiner, E, Andrews, R et al 2017, 'Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals', Platelets, vol. 28, no. 3, pp. 301-304.
  • Andrews, R & Gardiner, E 2016, 'Metalloproteolytic receptor shedding...platelets "acting their age"', Platelets, vol. 27, no. 6, pp. 512-518.
  • Ong, D, Aumann, H, Andrews, R et al 2016, 'M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction', Haemophilia, vol. 22, no. 4, pp. E345-E346.
  • Facey, A, Pinar, I, Arthur, J et al. 2016, 'A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets', Biochemistry, vol. 55, no. 8, pp. 1187-1194.
  • Lukito, P, Wong, A, Jing, J et al 2016, 'Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Iba and glycoprotein VI', Journal of Thrombosis and Haemostasis,14: 2253-2260.
  • Muthiah, K, Connor, D, Gardiner, E et al 2016, 'Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices', Journal of Heart and Lung Transplantation, vol 35 issue 6, pp 743-751.
  • Schoenwaelder, S, Darbousset, R, Cranmer, S et al 2016, '14-3-3 regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function', Nature Communications, vol 7, e12862 (15 pages).
  • Andrews, R & Gardiner, E 2015, 'ADAMs control inflammation from afar', Journal of Leukocyte Biology, vol. 97, no. 3, pp. 437-438.
  • Qiao, J, Al-Tamimi, M, Baker, R et al 2015, 'The platelet Fc receptor, Fc gamma RIIa', Immunological Reviews, vol. 268, no. 1, pp. 241-252.
  • Murphy, D, Hockings, L, Andrews, R et al 2015, 'Extracorporeal membrane oxygenation-hemostatic complications', Transfusion Medicine Reviews, vol. 29, no. 2, pp. 90-101.
  • Qiao, J, Davis, A, Morel-Kopp, M et al 2015, 'Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibβ in a patient with Bernard-Soulier syndrome', Annals of Hematology, vol. 94, no. 12, pp. 2069-2071.
  • Pinar, I, Arthur, J, Andrews, R et al 2015, 'Methods to determine the lagrangian shear experienced by platelets during thrombus growth', PLOS ONE (Public Library of Science), vol. 10, no. 12, pp. -.
  • Flierl, U, Nero, T, Lim, B et al 2015, 'Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators', Journal of Experimental Medicine, vol. 212, no. 2, pp. 130-138.
  • Trevillyan, J, Arthur, J, Jing, J et al 2015, 'Effects of abacavir administration on structural and functional markers of platelet activation', AIDS: 29: 2309-2313.
  • Gardiner, E, Andrews, R & Cuker, A 2014, 'DiagnoSTic assays for heparin-induced thrombocytopenia', British Journal of Haematology, vol. 166, no. 5, pp. 631-633.
  • Gardiner, E & Medcalf, R 2014, 'Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?', Journal of Thrombosis and Haemostasis, vol. 12, no. 10, pp. 1703-1705.
  • Gardiner, E & Andrews, R 2014, 'Structure and function of platelet receptors initiating blood clotting', Advances in Experimental Medicine and Biology, vol. 844, pp. 263-275.
  • Andrews, R & Gardiner, E 2014, 'Lymphomania', Blood, vol. 123, no. 20, pp. 3057-3058.
  • Gardiner, E & Andrews, R 2014, 'Platelet receptor expression and shedding: Glycoprotein Ib-IX-V and glycoprotein VI', Transfusion Medicine Reviews, vol. 28, no. 2, pp. 56-60.
  • Andrews, R, Arthur, J & Gardiner, E 2014, 'Neutrophil extracellular traps (NETs) and the role of platelets in infection', Thrombosis and Haemostasis, vol. 112, no. 4, pp. 659-665.
  • Pinar, I, Arthur, J, Andrews, R et al 2014, 'Techniques towards understanding shear dependent thrombus formation', 19th Australasian Fluid Mechanics Conference AFMC 2014, ed. Harun Chowdhury and Firoz Alam, Australasian Fluid Mechanics Society, Australia, pp. 1-4.
  • Andrews, R, Arthur, J & Gardiner, E 2014, 'Targeting GPVI as a novel antithrombotic strategy', Journal of Blood Medicine, vol. 5, pp. 59-68.
  • Gardiner, E & Andrews, R 2014, 'Plasma sGPVI: Changing levels in human disease', Thrombosis Research, vol. 133, no. 3, pp. 306-307.
  • Bishton, M, Gardiner, E, Harrison, S et al 2013, 'Histone deacetylase inhibitors reduce glycoprotein VI expression and platelet responses to collagen related peptide', Thrombosis Research, vol. 131, no. 6, pp. 514-520.
  • Gardiner, E & Andrews, R 2013, 'Platelets: Envoys at the infection frontline', Journal of Infectious Diseases, vol. 208, no. 6, pp. 871-873.
  • Qiao, J, Schoenwaelder, S, Mason, K et al. 2013, 'Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263)', Blood, vol. 121, no. 8, pp. 1479-1481.
  • Arthur, J, Shen, Y, Chen, Y et al. 2013, 'Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of type 1 diabetes', Journal of Diabetes Research, vol. 2013, pp. 370212-370212.
  • Arthur, J, Qiao, J, Shen, Y et al 2012, 'ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways', Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. 1133-1141.
  • Andrews, R & Gardiner, E 2012, 'Inside platelets...', Blood, vol. 119, no. 4, pp. 907-909.
  • Forestier, M, Al-Tamimi, M, Gardiner, E et al 2012, 'Diesel exhaust particles impair platelet response to collagen and are associated with GPIb alpha shedding', Toxicology in Vitro, vol. 26, no. 6, pp. 930-938.
  • Al-Tamimi, M, Tan, C, Qiao, J et al 2012, 'Pathologic shear triggers shedding of vascular receptors: A novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels', Blood, vol. 119, no. 18, pp. 4311-4320.
  • Qiao, J, Arthur, J, Collecutt, M et al. 2012, 'An acquired defect associated with abnormal signaling of the platelet collagen receptor glycoprotein VI', Acta Haematologica, vol. 128, no. 4, pp. 233-241.
  • Gardiner, E & Andrews, R 2012, 'Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction', Blood Reviews, vol. 26, no. 6, pp. 255-259.
  • Al-Tamimi, M, Arthur, J, Gardiner, E et al 2012, 'Focusing on plasma glycoprotein VI', Thrombosis and Haemostasis, vol. 107, no. 4, pp. 648-655.
  • Gardiner, E, Al-Tamimi, M, Andrews, R et al 2012, 'Platelet receptor shedding', Methods in Molecular Biology, vol. 788, pp. 321-339.
  • Gardiner, E, Ward, C & Andrews, R 2012, 'The NET effect of clot formation', Journal of Thrombosis and Haemostasis, vol. 10, no. 1, pp. 133-135.
  • Arthur, J, Shen, Y, Gardiner, E et al 2011, 'TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets', Journal of Thrombosis and Haemostasis, vol. 9, no. 1, pp. 163-172.
  • Schoenwaelder, S, Jarman, K, Gardiner, E et al 2011, 'Bcl-x(L)-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets', Blood, vol. 118, no. 6, pp. 1663-1674.
  • Al-Tamimi, M, Gardiner, E, Thom, J et al 2011, 'Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke', Stroke, vol. 42, no. 2, pp. 498-500.
  • Al-Tamimi, M, Grigoriadis, G, Tran, H et al 2011, 'Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa', Blood, vol. 117, no. 14, pp. 3912-3920.
  • Gardiner, E, Arthur, J, Shen, Y et al. 2010, 'GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events', Platelets, vol. 21, no. 4, pp. 244-252.
  • Wijeyewickrema, L, Gardiner, E, Gladigau, E et al 2010, 'Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI', Journal of Biological Chemistry, vol. 285, no. 16, pp. 11793-11799.
  • Qiao, J, Shen, Y, Gardiner, E et al. 2010, 'Proteolysis of platelet receptors in humans and other species', Biological Chemistry, vol. 391, no. 8, pp. 893-900.
  • Gardiner, E, Thomm, J, Al-Tamimi, M et al 2010, 'Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura', British Journal of Haematology, vol. 149, no. 4, pp. 625-628.
  • Berndt, M & Gardiner, E 2010, 'Biomarkers of vascular disease: GPVI shedding', Hematology Education: The education program for the Annual congress of the European Hematology Association, European Hematology Association, Netherlands, pp. 57-62.
  • Al-Tamimi, M, Mu, F, Arthur, J et al 2009, 'Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of Fc?RIIa and induce GPVI ectodomain shedding', Platelets, vol. 20, no. 2, pp. 75-82.
  • Al-Tamimi, M, Mu, F, Moroi, M et al 2009, 'Measuring soluble platelet glycoprotein VI in human plasma by ELISA', Platelets, vol. 20, no. 3, pp. 143-149.
  • Gardiner, E, Karunakaran, D, Arthur, J et al 2008, 'Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: De-ITAM-izing Fc?RIIa', Blood, vol. 111, no. 1, pp. 165-174.
  • Arthur, J, Gardiner, E, Kenny, D et al 2008, 'Platelet receptor redox regulation', Platelets, vol. 19, no. 1, pp. 1-8.
  • Gardiner, E 2008, 'Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura', Journal of Thrombosis and Haemostasis, vol. 6, no. 7, pp. 1175-1182.
  • Gardiner, E & Andrews, R 2008, 'The cut of the clot(h): Snake venom fibrinogenases as therapeutic agents', Journal of Thrombosis and Haemostasis, vol. 6, no. 8, pp. 1360-1362.
  • Gardiner, E, Karunakaran, D, Shen, Y et al 2007, 'Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases', Journal of Thrombosis and Haemostasis, vol. 5, no. 7, pp. 1530-1537.
  • Gardiner, E & Andrews, R 2007, 'Platelet receptor proteolysis: GPVI and ADAM10', Chimica Oggi (Chemistry Today), vol. 25, no. 5, pp. 58-61.
  • Arthur, J, Shen, Y, Berndt, M et al 2007, 'Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane', Journal of Biological Chemistry, vol. 282, no. 42, pp. 30434-30441.
  • Dunkley, S, Arthur, J, Evans, S et al 2007, 'A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathway', British Journal of Haematology, vol. 137, no. 6, pp. 569-577.
  • Andrews, R, Karunakaran, D, Gardiner, E et al 2007, 'Platelet receptor proteolysis: A mechanism for downregulating platelet reactivity', Arteriosclerosis Thrombosis and Vascular Biology, vol. 27, no. 7, pp. 1511-1520.
  • Wijeyewickrema, L, Gardiner, E, Shen, Y et al 2007, 'Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose', Toxicon, vol. 50, no. 8, pp. 1064-1072.
  • Wijeyewickrema, L, Gardiner, E, Moroi, M et al 2007, 'Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI', Thrombosis and Haemostasis, vol. 98, no. 6, pp. 1285-1290.
  • Arthur, J, Matzaris, M, Gardiner, E, et al 2005, 'Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets', Thrombosis and Haemostasis, vol. 93, no. 4, pp. 716-723.
  • Gardiner, E, Arthur, J, Kahn, M et al 2004, 'Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase', Blood, vol. 104, no. 12, pp. 3611-3617.
  • Andrews, R, Gardiner, E, Shen, Y et al 2003, 'Glycoprotein Ib-IX-V', The International Journal of Biochemistry and Cell Biology, vol. 35, no. 8, pp. 1170-1174.
  • Andrews, R, Shen, Y, Gardiner, E et al 2001, 'Platelet adhesion receptors and (patho)physiological thrombus formation', Histology and Histopathology, vol. 16, no. 3, pp. 969-980.
  • Gardiner, E, De Luca, M, McNally, T et al 2001, 'Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G', Blood, vol. 98, no. 5, pp. 1440-1447.
  • Gardiner, E, Andrews, R, Asazuma, N et al 2001, 'A Novel Viper Venom Metalloproteinase, Alborhagin, Is an Agonist at the Platelet Collagen Receptor GPVI', Journal of Biological Chemistry, vol. 276, no. 30, pp. 28092-28097.