Professor Elizabeth Gardiner

PhD
Group Leader

Professor Elizabeth Gardiner is the Head of the Department of Cancer Biology and Therapeutics in the John Curtin School of Medical Research at ANU, Canberra, Australia. She is Scientific Head of the National Platelet Referral and Research Centre at ANU and The Canberra Hospital. She has published 143 peer-reviewed research papers, commentaries and reviews in the area of platelet biochemistry and platelet function, particularly relevant to both thrombosis and bleeding in patients. She identified a novel mechanism for shedding of vascular receptors triggered by shear stress, enabling new capabilities in diagnostic and therapeutic reagent development.

She is a Trustee of the Thrombosis and Haemostasis society of Australia and New Zealand (THANZ), a Principal Editor and the Methods Editor of the journal Platelets, an Associate Editor of Arteriosclerosis, Thrombosis and Vascular Biology, and on the Editorial Board of Blood. She is Treasurer of the National Association of Research Fellows (NARF). She is Chair of the American Society of Hematology (ASH) Scientific Committee on Platelets and co-Chair of the International Society for Thrombosis and Haemostasis Biorheology Scientific Subcommittee. She has held executive roles in the Australian Vascular Biology Society.

 

Recent publications:

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM. Receptor clustering as a mechanism to regulate GPVI signalling in platelets. J Thromb. Haemost. (2017) in press.

Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM and Hoy JF. Decreased levels of platelet derived soluble glycoprotein VI detected prior to first diagnosis of coronary artery disease in HIV positive patients. Platelets (2016) Early Online: 1–4

Andrews RK, Arthur JF and Gardiner EE. Targeting GPVI as a novel antithrombotic strategy J. Blood Med. (2014) 5: 59-68. 

Gardiner EE and Andrews RK. Platelet receptor expression and shedding: GPIb-IX-V and GPVI. Transfus. Med. Rev. (2014) 28: 56-60.

Andrews RK, Arthur JF and Gardiner EE Neutrophil extracellular traps (NETs) and the role of platelets in infection. Thromb. Haemost. (2014) 112: 659-65.

Murphy DA, Hockings L, Andrews RK, Aubron C, Gardiner EE, Pellegrino V and Davis AK. Extracorporeal Membrane Oxygenation (ECMO) - Haemostatic Complications. Transfus. Med. Rev. (2015) 29: 90-101.

Andrews RK and Gardiner EE. Metalloproteolytic receptor shedding…platelets “acting their age”. Platelets (2016) In press.

Andrews RK and Gardiner EE. Basic mechanisms of platelet receptor shedding. Platelets (2016) In press.

Trist HM, Tan PS, Wines BD, Ramsland PA, Orlowski E, Stubbs J, Gardiner EE, Pietersz GA, Kent SJ, Stratov I, Burton DR and Hogarth PM. Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses. J. Immunol. (2014) 192: 792-803

Pennings GJ, Yong ASC, Wong C, Al-Tamimi M, Gardiner EE, Andrews RK, Kritharides L. Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma. Platelets (2014) 25: 639-642.

Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner EE, Noe BHT, Vainchenker W, Villeval J-L, Jandrot-Perrus M. Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm. Blood (2014) 124: 1136-45.

Au A, Sashindranath M, Borg R, Kleifeld O, Andrews RK, Gardiner EE, Medcalf RL and Samson A. Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase. Cell Death Dis (2014) 5: e1410 (15 pages)

Gitz, E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P and Watson SP. CLEC-2 expression is maintained on activated platelets and on platelet microparticles. Blood (2014) 124: 2262-70.

Flierl U, Nero TL, Lim B, Arthur JF, Yao J, Jung S, Gitz E, Pollitt AY, Jandrot-Perrus M,  Schäfer A, Nieswandt B, Andrews RK, Parker MW, #Gardiner EE, #Peter K. Phosphorothioate oligonucleotides are potent platelet activators: A caveat for nucleotide-based drug development? J. Exp. Med. (2015) 212: 129-37. #Equal senior authors

Sánchez Guiu MI, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, Garcia-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML, Rivera J. An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets. Thromb. Haemost. (2015) 114: 15-25

Qiao J, Davis AK, Morel-Kopp MC, Ward CM, Gardiner EE and Andrews RK. Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibβ in a patient with Bernard-Soulier syndrome. Ann Hematol (2015) 94: 2069-2071.

Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC and Metharom P. Thrombin-induced reactive oxygen species generation in platelets: a novel role for protease-activated receptor 4 and GPIba. Redox Biol. (2015) 6: 640-647.

Trevillyan JM, Arthur JF, Jing J, Andrews RK, Gardiner EE and Hoy JF. Effects of abacavir administration on structural and functional markers of platelet activation. AIDS (2015) 29: 2309-2313.

Pinar IP, Arthur JF, Andrews RK, Gardiner EE, Ryan K. and Carberry J. Methods to determine the Lagrangian shear experienced by platelets during thrombus growth. PLoS One (2015) 10: e0144860 (14 pages).

Muthiah K, Connor D, Ly K, Gardiner EE, Andrews RK, Qiao J, Rutgers D, Robson D, Low J, Jarvis S, Macdonald P, Dhital K, Jansz P, Joseph J and Hayward C. Longitudinal changes in haemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous flow left ventricular assist devices. J Heart Lung Transpl. (2016) 35: 743-751.

Facey A, Pinar IP, Arthur JF, Qiao J, Mado B, Carberry J, Andrews RK and Gardiner EE. A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets. Biochemistry (2016) 55: 1187-1194.

French SL, Arthur JF, Lee H, Andrews RK, Gardiner EE and Hamilton JR. Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood. J. Thromb. Haemost. (2016) 14: 1-13.

Healy LD, Itakura A, Chu T, Robinson DK, Bylund A, Phillips KG, Gardiner EE, McCarty OJT. Development of a platform to quantify the colocalization of neutrophil extracellular DNA and coagulation factors using immunofluorescence-based microscopy. J Immunol. Meth. (2016) 435: 77-84.

Ong DM, Aumann H, Andrews RK, Gardiner EE, Rodgers SE, Davis AK. M1761K mutation in the VWF A3 domain associated with impaired collagen binding and without platelet dysfunction. Haemophilia (2016) 22: e345-346.

Simone M. Schoenwaelder, Roxane Darbousset, Susan L. Cranmer, Hayley S. Ramshaw, Stephanie L. Orive, Sharelle Sturgeon, Yuping Yuan, YuYao, James R. Krycer, Joanna Woodcock, Jessica Maclean, Stuart Pitson, Zhaohua Zheng, Darren C. Henstridge, Dianne van der Wal, Elizabeth E. Gardiner, Michael C. Berndt, Robert K. Andrews, David E. James, Angel F. Lopez and Shaun P. Jackson (2016) 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications 7:12862