The Gut-Brain axis and chronic visceral pain.

Hosted by Dr Ehsan Kheradpezhouh

Abstract

This talk will focus on our recent discoveries and translational science investigating the nerve pathways innervating visceral organs to determine the causes of, and treatments for, Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD). This includes the role of different nerve pathways innervating the viscera, the channels and receptors underlying their function, and how these mechanisms are changed during acute and chronic visceral pain. In particular this talk will discuss how the microbiome can signal to the brain via a dialogue between specialized gut cells (enterochromaffin cells) and gut nerves and how these cell types contribute to the sex bias of gut pain.

Biography

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Professor Stuart Brierley is Director of the Visceral Pain Research Group, Director of the Hopwood Centre for Neurobiology, and Co-leader of the Lifelong Health theme at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide. He is an international expert in the ‘gut-brain axis’ and chronic visceral pain mechanisms. He is an NHMRC Investigator L1 recipient and received a NHMRC Research Excellence Award in 2016. His research is funded by the NHMRC, ARC, NIH (including collaborations with 2021 Nobel Laureate Prof David Julius) and industry.