Housed in a BSCII cabinet, the HTS workstation contains the following instruments/equipment:

• 6-axis Robotic Arm and dynamic scheduling control software
• JANUS Mini Automated Liquid Handling Workstation (equipped with pin tool/tip head)
• Opera Phenix high content imaging system
• Liconic Microplate 37oC CO₂ incubator
• Automated BioTek ELx406 Plate Washer and Reagent Dispenser
• Lid Handler & Barcode Reader
• Plate stacker
• IntelliCyt iQue Screener high throughput FACS analyser

Libraries

The screening library requirements of researchers are quite diverse; therefore it is not cost effective to order in and stock many different libraries. Instead, the ACBS will purchase a limited number of libraries to be stored in-house, and consult with individual users about their specific requirements. If a library is not stored within the ACBS, access to libraries that are available for researchers to access at academic rates will be enabled.

The types of drug/compound libraries that are available include, but are not limited to the “Australian Chemome” – encompassing Naturebank and other nature product collections, FDA-approved compound libraries, epigenetic modifying agents etc. For screeners that are interested in performing loss of function screens (e.g. RNAi, CRISPR), we have purchased the Dharmacon siGENOME SMARTpool human siRNA library (>18,000 protein coding targets), and we plan to purchase a CRISPR library in the near future (funding permitting). The ACBS can also enable the purchase of boutique RNAi/CRISPR/drug libraries from commercial sources depending on the specific requirement of the user.