Testing compounds that may have pro- or anti-angiogenic activities

Finally the Laboratory continues to use in vitro angiogenesis assays, developed in-house, to test compounds from other researchers that may have pro- or anti-angiogenic activities. Pro-angiogenic compounds represent potential therapeutics for cardiovascular disease and anti-angiogenic compounds could be used as anti-cancer agents. The most successful of these collaborations has been with where legume associated nodulation factors, which are modified chito-oligosaccharides, have been shown, depending on their structure, to be either pro- or anti-angiogenic. Similarly, a unique pro-angiogenic molecule has been identified and isolated from the sap of soya beans.