Role of deeply conserved RNA structures as novel regulators of pathogenesis-associated pathways

The function and precise mechanisms of structural RNA families remain largely undetermined to date and represent a large gap in our knowledge, despite their clear potential as new ways of manipulating key gene expression pathways of evident medical importance. In this project, we are experimentally determining the mechanisms and functions of two novel RNA families and their interaction with RNA binding proteins and discover and quantify pathogenesis-associated phenotypic changes induced by these cis-regulatory structural RNA families.

This project is a collaboration with Brian Parker.