Predictive models of RNA biochemical modifications and their role in RNA processing
RNA Sequencing with Oxford Nanopore Technologies produces a stream of signals that can be decoded to uncover the properties of individual molecules. Most of the current methods are devoted to extracting the sequence of nucleotides or a pair of biochemical modifications. We are interested in the development of deep neural networks to analyse and interpret signal data to extend the types of nucleotide modifications that can be detected from Nanopore sequencing. We plan to apply these methodologies to study the interplay between RNA modifications and RNA processing, including splicing and translation, and their role in cancer progression.