Migration, effector function and transcriptional regulation of Th17

Th17 cells define one of the three major T helper cell populations: Th1, Th2 and Th17. They are key inflammatory drivers, characterised by their production of IL-17. Former work by Dr Bruestle identified IRF4 as a transcription factor necessary for Th17 differentiation and MALT1 as a paracaspase indispesible for the effector function of Th17 cells. We are currently investigating different molecules involved in Th17 migration, differentiation and effector function by taking advantage of KO mouse models as well as models of Th17 mediated autoimmunity.