A longitudinal study of depression, anxiety, substance use and cognitive change: PATH Through Life

We investigate how genetic variation, and gene-environmental interactions cause people to decline, physically and mentally, at different rates as they age. The study is based on two large, well-studied, community-based samples of people in their 40s and 60s. The results contribute to knowledge needed to improve the way health is managed across the lifespan.


  • Kaarin Anstey, Helen Christensen, Kathy Griffiths, Peter Butterworth, Nic Cherbuin, Centre for Mental Health Research, ANU
  • Andrew Mackinnon, Tony Jorm, ORYGEN Research Centre & Department of Psychiatry, The University of Melbourne
  • Perminder Sachdev, Wei Wen, Neuropsychiatric Institute, Prince of Wales Hospital & University of New South Wales