Genetics of the host response to multi-drug resistant bacteria or “superbugs”

Hospital-acquired infections are caused by bacteria, viruses, and fungi. These infections are strongly increasing in prevalence to 1 in 25 patients in Australia, Europe and USA. Over 700,000 patients in the US a year contract a hospital-acquired infection. Most of these hospital-acquired infections are caused by multi-resistant bacteria to antibiotics “superbugs”. There are growing concerns due to the acquisition of multi-resistance to antibiotics from the bacteria and the lack of novel antibiotics in the market.

We are interested in understanding how the host can combat these multi-resistant bacterias and how bacterias escape the host immune system, using CRISPR/Cas9 gene editing technology.