The research successes of Molecular Biology and Biochemistry have given us detailed pictures of the regulatory and metabolic states of cells and tissues, yet we know little about how these states affect each other. We use next generation sequencing (NGS) and mass spectrometry to investigate the possible existence of regulatory interactions between ribonucleic acids, enzymes and metabolites to connect gene expression and metabolism.
The investigation of the relationships between the constituents of the regulatory interactions is supported by bioinformatics analysis of publicly available gene expression and NGS datasets. Integration of this data allows interpretation of our own experimental results in a broader context and can also be used to aid in the design of validation experiments through the prioritisation of potential target proteins.
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