5-methylcytosine as a transcriptome-wide epitranscriptomic mark

The role of the modified base 5-methylcytosine (m5C) as an epigenetic mark in DNA is well appreciated and intensely studied. By comparison, the cellular functions of the same base modification in RNA molecules are poorly understood. We are applying NGS technology to chart the occurrence of m5C in eukaryotic cellular RNAs and endeavour to unravel its function(s) for different classes of RNA.

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