Canberra Clinical Phenomics Service (CCPS)

The Canberra Clinical Phenomics Service

About

At Canberra Clinical Phenomics Service (CCPS), we are dedicated to advancing the understanding, diagnosis, and treatment of complex diseases.

For people dealing with rare immune disorders, conventional diagnostic methods may prove insufficient. The Canberra Clinical Phenomics Service provides specialized analysis of human blood samples for markers of immune and inflammatory conditions. Our experts have access to the latest technologies that unravel the intricate cells and signaling molecules that underpin our immune system.

Who are we?

Director
Associate Professor Katrina Randall, Director of Clinical Immunology (Canberra Health Services)

Manager
Dr. Euan McNaughton

Research Team Scientists

Dr Ainsley Davies

Dr Zhijia Yu

Bioinformaticians

Philip Wu

Minnal Abbasi

Patient Liaison

Ann-Maree Hatch

Clinical Advisory Committee – provides high-level clinical advice, determines patient cohorts, recruits patients to research studies, and upholds relationships with health services.

Executive Governance Committee – provides high-level oversight of the service, the strategic plan, and our relationships with stakeholders.

Services

Our services are presently designed for research purposes and are available to clinicians and academics. We are actively working towards achieving accreditation for human diagnostic use.

Benefits of the Service

  • Efficiency: Save time and resources by avoiding months of in-house assay optimization.
  • Quality Assurance: Rely on our rigorous quality control system, which includes WHO Reference materials and participation in External Quality Assurance Programs.
  • Innovation: Access cutting-edge scientific and analytical techniques to stay at the forefront of your field.

Current Services

Cellular immunophenotyping - Lymphocyte panel

This panel utilises spectral cytometry to analyse 30 markers simultaneously, allowing characterisation of 62 T cell and B cell subpopulations in a single tube.
From peripheral blood mononuclear cells (PBMCs), we can consistently detect populations including T cells (alpha-beta and gamma-delta); CD4+ and CD8+ naïve, TEMRA, central and effector memory; cTfh cells, Tregs and Tfr cells; CD57+ exhausted T cells and B cells; naïve, T1 and T2 transitional; switched and unswitched memory; IgG+ and IgA+ memory; Igκ and Igλ chain expression, Bregs, atypical CD11c+ B cells; plasmablasts and plasma cells.

Cytokine analysis

This panel measures a range of inflammatory cytokines, including IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 p70, IL-13 and TNF-α

Analysis services

Our skilled scientists can offer assistance with analysis of results, including the use of machine learning techniques to identify system-wide patterns of change in disease biomarkers.

Services in development

Myeloid panel

We are currently developing a spectral cytometry myeloid panel to complement our lymphocyte panel.

Patients and Healthy Blood Donors

What is the testing?

Lymphocytes are cells in the immune system which help your body fight viruses, bacteria and cancer. Different types, or “subsets”, of lymphocytes have different roles, such as killing infected cells or controlling the immune response.

Cytokines are proteins which the cells of the immune system use to communicate, such as activating resting cells and guiding them towards an infection. If too many cytokines are produced, it can cause conditions like rheumatoid arthritis.

Our testing measures these cells and proteins to help doctors and scientists understand the cause of conditions caused by, or related to, their immune system. We aim to eventually use this testing to help with diagnosis and treatment.

For patients - How to access our services

If you or a family member are interested in accessing our blood testing services, please speak to your doctor. They can contact us by completing an Expression of Interest form (linked here) or emailing us at chm.clinicalphenomics@anu.edu.au .

Healthy Blood Donors

Why we need you

 We are trying to identify changes in cells or proteins in people with conditions caused by, or related to, their immune system. To show the changes in cells or proteins are associated with disease, we need to compare them against results from healthy people.

Exclusion criteria

  • personal or strong family history of immunological disease
  • treatment with immune-modulating drugs
  • recent radiotherapy
  • organ transplantation
  • malignancy
  • type 2 diabetes
  • pregnant
  • Hepatitis C

Additionally, on the day that you are donating blood, you are not eligible if you have had any contagious illness or received any vaccine within 4 weeks.

How to book a blood donation

All blood donations are collected on weekdays at Canberra Hospital, Woden at ACT Pathology. If you would like to participate as a healthy control, either on a single occasion or on an ongoing basis, please return your completed consent form to admin.ccps@anu.edu.au

We will contact you to arrange a date for your blood donation.

Links to healthy control information sheet and consent form

Canberra Clinical Phenomics Service Healthy Control Consent Form Version 2 dated 12 May 2023 (PDF, 436.38 KB)

Canberra Clinical Phenomics Service Healthy Control Information Sheet Version 1 dated 22 March 2023 (PDF, 894.67 KB)

Clinicians and Researchers

How to reach us?

If you are interested in collaborating as a clinician or researcher, please email us at chm.clinicalphenomics@anu.edu.au

The Australian National University, Hugh Ennor Building, 117 Garran Road, Canberra ACT 2601