A data revolution is underway in modern biological science, now that obtaining the genome sequence for an individual organism has become routine and increasingly affordable due to exponential advances in sequencing technologies.
The Neural Coding Group has a broad interest in systems neuroscience spanning areas such as sensory coding, adaptation and behaviour.
We aim to understand the complex molecular processes by which these transcription factors interact with signal transduction pathways, chromatin, RNA and other proteins in order to orchestrate these important developmental processes
We are interested in how the mammalian brain processes sensory information received from the external world.
The Synaptic Mechanisms Laboratory investigates how individual synapses in the central nervous system function and how they are modulated.
Cancer Metabolism & Genetics
The work of the Molecular Genetics Group is aimed at gaining a fundamental understanding of the molecular and biochemical mechanisms that underlie individual responses to such compounds.
The Bruestle Group - Inflammatory T Cell Responses, is focusing on different T helper cell subsets and how they modulate immunity in diverse autoimmune mouse models.
In the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infections. Our group aims to understand why these people are resistant to pathogens using a mouse as a model.
The Casarotto Group explores how the structural properties of biological molecules can impact on the biological process involved in health and disease.
The focus of our research is understanding how to generate effective immunity against the malaria parasite Plasmodium.
The translational research group in immunology is seeking to understand the genetic etiology and cellular pathogenesis of human diseases arising from dysregulated immunity.
Our work is a multi-disciplinary collaborative venture between physicists and neuroscientists to make use of novel optical techniques to analyse the brain. We are mainly interested in using a 3D holographic projection of multiple foci from a single laser source.
The Dehorter Group aims to determine how interneurons shape neuronal networks activity and contribute to circuits balance in health and disease.
The research of the Group is dedicated to understanding the cellular mechanisms that underlie changes in cytoplasmic calcium signalling in general, and more specifically those mechanisms which trigger contraction following an electrical signal on the surface membrane of skeletal and cardiac muscle fibres.
We study the evolutionary interplay between humans and their environments to understand how this dynamic process gave rise to our complex biology; how it made us such a diverse species; and how it impacts our health and wellbeing.
The main focus of the lab is to investigate novel pathways regulating B cell development and function.
The Fischer lab investigates the connection between chromatin structure, pervasive transcription and RNA surveillance, and their influence on genomic stability.
I am interested in the genetics of several diseases that affect isolated, less affluent populations. My group works on the host response to infection by malarial parasites.
The group investigates the molecular basis of processes coordinated by platelets across vascular biology. Primary areas of interest focus on the biochemical and molecular analysis of immune-based platelet disorders seen clinically in immunothrombocytopenia (ITP), thrombotic thrombocytopenic purpura (TTP) and heparin-induced thrombocytopenia (HIT) and the group has expanded their core interest to focus on thrombosis associated with cancer.
Our group discovers molecular and cellular mechanisms and genes regulating the immune response
We aim to understand how proteins carry out their functions in the cell and how they have been sculpted by evolution to do so. Our findings provide the basic knowledge to understand proteins’ normal functions in plants and animals, and their dysfunctions in disease.
This group focuses on the molecular analysis of major pro-malignant transcription factor networks that operate in cancer cells using an integrated approach that combines cell biology, genomics, proteomics, biochemistry, genetics, bioinformatics and strong interactions with oncologists in the clinic.
We are interested in learning gene expression control mechanisms through the lens of host-transposon interaction and how they, in turn, play roles in animal development.
Our primary research interest is to elucidate the molecular mechanisms underlying phototransduction and adaptation - the conversion of light into a neural signal, and subsequent recovery, in retinal rod and cone photoreceptors and in bipolar cells.
Dr Li is a molecular pharmacologist and osteoimmunologist with interests in understanding the processes that control a ‘foreign body reaction or response’ initiated by biomaterials implanted into bone or exposed to human bone cells.
Lipotek is a developer of targeted vaccine delivery and adjuvant technologies.
My interest in the optical designs of invertebrate eyes led me to study how visual systems squeeze real-time information into brains of limited capacity
The Man Group investigates the role of innate immunity in infectious diseases and cancer.
The main focus of our research is to understand the host response to malarial infection.
Our lab studies a number of retinal diseases, with our main focus on finding novel diagnostics and treatment options for Age-Related Macular Degeneration (AMD).
The Cancer and Vascular Biology Group has been working for a number of years on the molecular basis of cell adhesion, cell migration and cell invasion, with a particular emphasis on the immune system, tumour metastasis and the growth of new blood vessels (angiogenesis).
Our group studies the mechanisms and transcriptome-wide patterns of eukaryotic mRNA translation as one of life’s core processes and its regulation by RNA-binding proteins and non-coding RNA as a means of controlling gene activity.
We aim to examine how the expression of macula genes varies over a lifetime.
The Quinn Group's current research involves generating genetic models using Drosophila melanogaster to understand the initiation and progression of human cancer
Our laboratory is attempting to understand the problems associated with HIV vaccine failure in humans. Our studies were the first to demonstrate that IL-4 and predominantly IL-13 play an important role in modulating “quality or avidity” of HIV-specific CD8 T cells in a vaccine route dependent manner where mucosal vaccination induced higher avidity CD8 T cells compared to systemic vaccination.
We propose that during T1D development, neutrophils are activated by platelets to release NETs/histones inside blood vessels and within islets, resulting in initial or early beta cell damage.
We study brain abnormalities in rats with Hirschsprung's disease.
We work in three different areas, each addressing a particular cellular property of transmission between cells. We record from cell pairs in various layers of cerebral cortex and investigate the characteristics of communication between cells. The goal is to determine the efficacy of the contacts between the cells, the mechanisms underlying its modulation, as well as the efficiency of information transfer between cells.
The Neuronal Signalling Group studies the electrical and chemical signals that nerve cells in the brain use to communicate with one another.
Chromatin and transcriptional regulation during development
Our research interests are Immunity to virus infection and in particular CD8+ T cells, poxviruses and herpesviruses and antigen presentation.
My research has been focused on degenerative diseases of the retina, from the molecular and cellular level to the clinical.
The Humoral Immunity and Autoimmunity Group is investigating the cellular and molecular events that regulate production and selection versus elimination of memory B cells, which is of critical importance to understand how best to harness immune responses against infection, and to mitigate against autoimmunity.
The Wen Group is a newly formed computational Biology group.
One major aim is to study how the cytokines activate their receptor systems by binding to the receptors on the outside of cells and transmit intracellular signals which promote growth, differentiation, survival and activation of leukocytes. We use the techniques of protein expression, crystallization and X-ray crystallography to determine the structure of the receptors and site-directed mutagenesis to elucidate function. We are also interested in revealing the molecular mechanisms which promote self-renewal and differentiation of blood cell progenitors.
Dr Di Yu and his team are investigating the molecular mechanisms by which T cells control the competence and balance of the immune system.