Projects

Project Status
A novel mechanism of epigenetic information transfer between different cell types Potential
Characterisation of the role of H2A.B spermatogenesis during heat stress Potential
Click chemistry enables evaluation of the molecular mechanism of the 2nd generation RNA polymerase I inhibitor, PMR-116 Current
Embryonic development: How does elevated Wnt signalling cause heart defects? Potential
Exploring novel pathways of platelet biogenesis (thrombopoiesis). How does the body respond to a crisis of platelet numbers? Current
Gene regulation through interactions between RNA, enzymes and metabolites Potential
How does alcohol combine with genetics to alter brain development? Potential
How is H2A.B involved in Hodgkin lymphoma carcinogenesis? Potential
Innovative methods to detect rapid translational control. Current
Investigating a role of C/T antigens in spermatogenesis and cancer Potential
Investigating platelet receptor shedding mechanisms in physiological and pathophysiological conditions Current
Investigation of a role of H2A.B3 in piRNA biology Potential
Mini-brain systems to identify novel treatments for brain cancer Current
Novel algorithms to study transcriptome variation with long-read sequencing Current
Potential role of phase separation in transposon defence Potential
Predictive models of RNA biochemical modifications and their role in RNA processing Current
Rapid translation-based stress responses to environmental changes. Current
Solving mysteries of the neural stem cell niche to understand brain cancer Current
To determine the role of histone variants, and other important epigenetic regulators, in regulating gene transcription and splicing. Potential
To elucidate the role of the epigenome, including the histone variant H2A.Z, in regulating the 3-dimensional architecture of the genome by inhibiting the expression of epigenetic regulators cellular differentiation. Potential
To study the role of histone variants and other epigenetic regulators in controlling pre-mRNA splicing on brain function and spermatogenesis using mouse knockout models. Potential
Tracking ribosome footprints to reveal the intricacy and control of translation Potential
Translational control in cancer. Current
What are the molecular events underpinning clotting and bleeding in the setting of haematological cancer? Current

Updated:  8 November 2021/Responsible Officer:  Director, JCSMR/Page Contact:  Web Manager