Emeritus Professor Trevor Lamb

BE (Melbourne), ScD (Cambridge), FRS, FAA
Emeritus Professor

Professor Trevor Lamb is Emeritus Professor of Neuroscience at the John Curtin School of Medical Research in the Australian National University. He obtained a degree in Electronic Engineering from the University of Melbourne, and then a PhD in Physiology from the University of Cambridge, where he remained for over 30 years before returning to Australia in 2003 as a Federation Fellow. His research involves the cellular and molecular mechanisms by which retinal rod and cone photoreceptors respond to light, and, more recently, the evolution of these cells and of our eye. His 90 publications have received over 8,800 citations. He was elected a Fellow of the Royal Society in 1993, and a Fellow of the Australian Academy of Science in 2005, following his return to Australia. Despite taking early retirement in 2011, he actively continues his research.

Research interests

Transduction and adaptation in vertebrate rod and cone photoreceptors.

Evolution of photoreceptors, the retina, and the eye.

  • Hofmann, K & Lamb, T 2023, 'Rhodopsin, light-sensor of vision', Progress in Retinal and Eye Research, vol. 93, no. March 2023, p. 101116.
  • Lamb, T 2022, 'Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction', The Journal of Physiology, vol. 600, no. 21, pp. 4585-4601.
  • Lamb, T 2021, 'Analysis of paralogons, origin of the vertebrate karyotype, and ancient chromosomes retained in extant species', Genome Biology and Evolution, vol. 13, no. 4, evab044.
  • Bocchero, U, Falleroni, F, Mortal, S et al. 2020, 'Mechanosensitivity is an essential component of phototransduction in vertebrate rods', PLoS Biology, vol. 18, no. 7, pp. 1-19.
  • Lamb, T 2020, 'Evolution of the genes mediating phototransduction in rod and cone photoreceptors', Progress in Retinal and Eye Research, vol. 76, 100823.
  • Margrain, T, Atkinson, D, Binns, A et al. 2020, 'Functional imaging of the outer retinal complex using high fidelity imaging retinal densitometry', Scientific Reports, vol. 10, 4494.
  • Hart, N, Lamb, T, Patel, H et al. 2020, 'Visual opsin diversity in sharks and rays', Molecular Biology and Evolution, vol. 37, no. 3, pp. 811-827.
  • Lamb, T & Kraft, T 2020, 'A quantitative account of mammalian rod phototransduction with PDE6 dimeric activation: Responses to bright flashes', Open Biology, vol. 10, 190241.
  • Heck, M, Hofmann, K, Kraft, T et al. 2019, 'Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 18, pp. 8653-8654.
  • Lukowski, S, Lo, C, Sharov, A et al. 2019, 'A single-cell transcriptome atlas of the adult human retina', The EMBO Journal, vol. 38, no. 18, pp. 1-15.
  • Lamb, T & Hunt, D 2018, 'Evolution of the calcium feedback steps of vertebrate phototransduction', Open Biology, vol. 8, 180119.
  • Luu, C, Tan, R, Caruso, E et al. 2018, 'Topographic Rod Recovery Profiles after a Prolonged Dark Adaptation in Subjects with Reticular Pseudodrusen', Ophthalmology Retina, vol. 2, no. 12.
  • Lamb, T, Heck, M & Kraft, T 2018, 'Implications of dimeric activation of PDE6 for rod phototransduction', Open Biology, vol. 8, 180076.
  • Qureshi BM, Behrmann E, Schöneberg J et al. 2018, 'It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods', Open Biology, vol. 8, 180076.
  • Lamb, T, Patel, H, Chuah, A et al 2018, 'Evolution of the shut-off steps of vertebrate phototransduction', Open Biology, vol. 8, 170232.
  • Lamb, T & Hunt, D 2017, 'Evolution of the vertebrate phototransduction cascade activation steps', Developmental Biology, vol. 431, no. 1, pp. 77-92.
  • Lamb, T, Patel, H, Chuah, A et al 2016, 'Evolution of Vertebrate Phototransduction: Cascade Activation', Molecular Biology and Evolution, vol. 33, no. 8, pp. 2064-2087.
  • Lamb, T 2016, 'Why rods and cones?', Eye, vol. 30, no. 2, pp. 179-185pp.
  • Lamb, T & Kraft, T 2016, 'Quantitative modeling of the molecular steps underlying shut-off of rhodopsin activity in rod phototransduction', Molecular Vision, vol. 22, pp. 674-696.
  • Lamb, T, Corless, R & Pananlos, A 2015, 'The kinetics of regeneration of rhodopsin under enzyme-limited availability of 11-cis retinoid', Vision Research, vol. 110, no. Part A, pp. 23-33.
  • Lamb, T 2013, 'Evolution of phototransduction, vertebrate photoreceptors and retina', Progress in Retinal and Eye Research, vol. 36, pp. 52-119.
  • Mahroo, O & Lamb, T 2012, 'Slowed recovery of human photopic ERG a-wave amplitude following intense bleaches: A slowing of cone pigment regeneration?', Documenta Ophthalmologica, vol. 125, no. 2, pp. 137-147.
  • Mahroo, O, Ban, V, Bussman, B et al 2012, 'Modelling the initial phase of the human rod photoreceptor response to the onset of steady illumination', Documenta Ophthalmologica, vol. 124, no. 2, pp. 125-131.
  • Ruseckaite, R, Lamb, T, Pianta, M et al 2011, 'Human scotopic dark adaptation: Comparison of recoveries of psychophysical threshold and ERG b-wave sensitivity', Journal of Vision, vol. 11, no. 8, pp. 1-16.
  • Vogalis, F, Shiraki, T, Kojima, D et al 2011, 'Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses', Journal of Physiology, vol. 589, no. 9, pp. 2321-2348.
  • Lamb, T 2011, 'Evolution of the eye', Scientific American, vol. 305, no. 1, pp. 64-69.
  • Lamb, T 2009, 'Evolution of vertebrate retinal photoreception', Philosophical Transaction of the Royal Society: B- Biological Sciences, vol. 364, no. 2009, pp. 2911-2924.
  • Lamb, T, Arendt, D & Collin, S, eds, 2009, The evolution of phototransduction and eyes, 364.
  • Cameron, A, Miao, L, Ruseckaite, R et al 2008, 'Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurements', Journal of Physiology, vol. 586, no. 22, pp. 5419-5436.
  • Lamb, T, Pugh, E & Collin, S 2008, 'The origin of the vertebrate eye', Evolution: Education and Outreach, vol. 1, no. 4, pp. 415-426.
  • Lamb, T, Collin, S & Pugh, E 2007, 'Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup.', Nature Reviews Neuroscience, vol. 8, no. (December), pp. 960-975.
  • Cameron, A, Mahroo, O & Lamb, T 2006, 'Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram', Journal of Physiology, vol. 575, no. 2, pp. 507-526.
  • Lamb, T & Pugh, E 2006, 'Phototransduction, dark adaption, and rhodopsin regeneration', Investigative Ophthalmology and Visual Science, vol. 47, no. 12, pp. 5138-5153.
  • van Hateren, J & Lamb, T 2006, 'The photocurrent response of human cones in fast and monophasic', BMC Neuroscience, vol. 7, no. 34, pp. 1-8.
  • Hamer, R, Nicholas, S, Tranchina, D et al. 2005, 'Towards a unified model of verebrate rod phototransduction', Visual Neuroscience, vol. 22, pp. 417-436.
  • Kenkre, J, Moran, N, Lamb, T et al. 2005, 'Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures', Journal of Physiology, vol. 567, no. 1, pp. 95-112.
  • Jaervinen, J & Lamb, T 2005, 'Inverted photocurrent responses from amphibian rod photoreceptors: role of membrane voltage in response recovery', Journal of Physiology, vol. 566, no. 2, pp. 455-466.
  • Wenzel, A, Oberhauser, V, Pugh, E et al 2005, 'The Retinal G Protein-coupled Receptor (RGR) Enhances Isomerohydrolase Activity Independent of Light', Journal of Biological Chemistry, vol. 280, no. 33, pp. 29874-29884.
  • Lamb, T & Burns, M 2004, 'Visual transduction by rod and cone photoreceptors', in Leo Chalupa & J.S.Werner (ed.), The Visual Neurosciences, MIT Press, Cambridge, USA, pp. 215-233.
  • Lamb, T & Pugh, E 2004, 'Dark adaptation and the retinoid cycle of vision', Progress in Retinal and Eye Research, vol. 23, no. 3, pp. 307-380.
  • Mahroo, O & Lamb, T 2004, 'Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics', Journal of Physiology, vol. 554, no. 2, pp. 417-437.
  • Friedburg, C, Allen, C, Mason, P et al 2004, 'Contribution of cone photoreceptors and post-receptoral mechanisms to the human photopic electroretinogram', Journal of Physiology, vol. 556, no. 3, pp. 819-834.
  • Hamer, R, Nicholas, S, Tranchina, D et al 2003, 'Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses', Journal of General Physiology, vol. 122, no. 4, pp. 419-444.
  • Arshavsky, V, Lamb, T & Pugh, E 2002, 'G Proteins and Phototransduction.', Annual Review of Physiology, vol. 64, pp. 153-187.
  • Friedburg, C, Thomas, M & Lamb, T 2001, 'Time course of the flash response of dark-and-light adapted human rod photoreceptors derived from the electroretinogram', Journal of Physiology, vol. 534, no. 1, pp. 217 - 242.