Dr James Hearn

Postdoctoral Fellow

Research interests

  • Megakaryocytes and platelets
  • Haematopoiesis
  • Haematological malignancies

A novel EGR‐1 dependent mechanism for YB‐1 modulation of paclitaxel response in a triple negative breast cancer cell line

Annette Lasham, Sunali Y Mehta, Sandra J Fitzgerald, Adele G Woolley, James I Hearn, Daniel G Hurley, Igor Ruza, Michael Algie, Andrew N Shelling, Antony W Braithwaite, Cristin G PrintInternational journal of cancer 139 (5), 1157-1170


Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Taryn N Green, Justin R Hamilton, Marie-Christine Morel-Kopp, Zhaohua Zheng, Ting-Yu T Chen, James I Hearn, Peng P Sun, Jack U Flanagan, Deborah Young, P Alan Barber, Matthew J During, Christopher M Ward, Maggie L Kalev-Zylinska, Platelets 28 (8), 799-811


Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes

ML Kalev-Zylinska, JI Hearn, J Rong, M Zhu, J Munro, J Cornish, N Dalbeth, RC Poulsen, Osteoarthritis and cartilage 26 (11), 1518-1530


N-methyl-D-aspartate receptor hypofunction in Meg-01 cells reveals a role for intracellular calcium homeostasis in balancing megakaryocytic-erythroid differentiation

James I Hearn, Taryn N Green, Martin Chopra, Yohanes NS Nursalim, Leandro Ladvanszky, Nicholas Knowlton, Cherie Blenkiron, Raewyn C Poulsen, Dean C Singleton, Stefan K Bohlander, Maggie L Kalev-Zylinska, Thrombosis and haemostasis 120 (04), 671-686


N‐methyl‐d‐aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines

Tania Kamal, Taryn N Green, James I Hearn, Emma C Josefsson, Marie‐Christine Morel‐Kopp, Christopher M Ward, Matthew J During, Maggie L Kalev‐Zylinska, Research and practice in thrombosis and haemostasis 2 (1), 125-138


Ionotropic glutamate receptors in platelets: opposing effects and a unifying hypothesis

Maggie L Kalev-Zylinska, Marie-Christine Morel-Kopp, Christopher M Ward, James I Hearn, Justin R Hamilton, Anna Y Bogdanova, Platelets 32 (8), 998-1008


N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned?

ML Kalev-Zylinska, JI Hearn, A Makhro, A Bogdanova, Frontiers in Physiology 11, 577


Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas

BB Woodhouse, TJ Robb, JI Hearn, PS Houseman, G Hayward, R Miller, AP Restall, M Findlay, B Lawrence, CG Print, K Parker, C Blenkiron, The British journal of dermatology 179 (5), 1197-1198


The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?

RC Poulsen, JI Hearn, N Dalbeth, Rheumatology 60 (7), 3048-3057


Micropatterned growth surface topography affects extracellular vesicle production

CL Hisey, JI Hearn, DJ Hansford, C Blenkiron, LW Chamley, Colloids and Surfaces B: Biointerfaces 203, 111772


Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

James I Hearn, Taryn N Green, Colin L Hisey, Markus Bender, Emma C Josefsson, Nicholas Knowlton, Juliane Baumann, Raewyn C Poulsen, Stefan K Bohlander, Maggie L Kalev-Zylinska, Blood, The Journal of the American Society of Hematology 139 (17), 2673-2690


The Chondrogenic Potential of First-Trimester and Term Placental Mesenchymal Stem/Stromal Cells

Joanna L James, Anandita Umapathy, Sonia Srinivasan, Claire N Barker, Anna Brooks, James Hearn, Ashika Chhana, Eloise Williams, Hilary Sheppard, Sue R McGlashan, Cartilage 13 (2_suppl), 544S-558S


IL-1β induces changes in expression of core circadian clock components PER2 and BMAL1 in primary human chondrocytes through the NMDA receptor/CREB and NF-κB signalling pathways

M Alhilali, JI Hearn, J Rong, L Jain, SM Bolam, AP Monk, JT Munro, N Dalbeth, RC Poulsen, Cellular Signalling 87, 110143